Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers
The invention describes novel isolated, purified, 10,17-dihydroxy-docosahexaenoic acids, esters, derivatives and their preparation.
1. A purified compound of formula (I), (III), (IV), (V), or (VIII):
wherein R is a hydrogen atom, an alkyl group, or a pharmaceutically acceptable salt; P 1 and P 2 are each, individually, a hydrogen atom or a protecting group and * indicates bonds are, independently, in the R or S configuration.
2. The compound of claim 1 , wherein when P 1 and P 2 are both hydrogen atoms, then R is other than a hydrogen atom.
3. The compound of claim 1 , wherein P 1 and P 2 are each hydrogen atoms and R is a hydrogen atom.
4. A composition comprising a compound of claim 1 , and a pharmaceutically acceptable carrier.
5. A method to treat airway inflammation comprising administration of a therapeutically acceptable amount of a compound of claim 1 .
6. The method of claim 5 , wherein P 1 and P 2 are each hydrogen atoms and R is a hydrogen atom.
7. The method of claim 5 , wherein said airway inflammation is asthma.
8. The method of claim 5 , wherein when P 1 and P 2 are both hydrogen atoms, then R is other than a hydrogen atom.
9. A method to treat airway inflammation comprising administration of a therapeutically acceptable amount of a composition of claim 4 .
10. The method of claim 9 , wherein P 1 and P 2 are each hydrogen atoms and R is a hydrogen atom.
11. The method of claim 9 , wherein said airway inflammation is asthma.
12. The method of claim 5 , wherein P 1 and P 2 are each hydrogen atoms and R is a hydrogen atom.
13. The method of claim 5 , wherein said airway inflammation is asthma.