Therapeutic use of tetrathiomolybdate
Tetrathiomolybdate is for use in therapy of a condition requiring reduced metabolism of an organ or whole body, e.g. myocardial infection, stroke or ischaemia-reperfusion injury.
1. A method for acute treatment of ischemia-reperfusion injury (IRI) in a subject that has undergone ischemic injury and is now at risk for acute injury caused by reperfusion following said ischemic injury, wherein said method comprises administering, to said subject, tetrathiomolybdate (TTM), via continuous infusion, wherein a total dose of up to 20 mg/kg TTM is administered to the subject over a period of one hour or less, such that within two hours of initiating treatment with TTM, there occurs in the subject a decrease in at least one of oxygen consumption and carbon dioxide production, thereby providing acute treatment of said IRI.
2. The method, according to claim 1 , wherein the injury is of a head.
3. The method, according to claim 1 , wherein the injury is of a brain.
4. The method, according to claim 1 , wherein the treatment is for stroke.
5. The method, according to claim 1 , wherein the injury is of a heart.
6. The method, according to claim 5 , wherein the subject is undergoing a procedure selected from coronary artery bypass surgery, open heart surgery and treatment for coronary artery thrombosis.
7. The method, according to claim 1 , wherein the injury is of a leg or kidney.
8. The method, according to claim 7 , wherein the subject is undergoing aortic cross-clamping for peripheral vascular surgery.
9. The method, according to claim 1 , wherein the treatment is for shock.
10. The method, according to claim 1 , wherein the treatment is for hypoxemia.
11. The method, according to claim 1 , wherein the treatment is for hemorrhage.
12. The method, according to claim 1 , wherein the treatment is for cardiac arrest.
13. The method, according to claim 1 , wherein the TTM is administered via intravenous administration.