Deuterium-enriched donepezil
The present application describes deuterium-enriched donepezil, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
1. A deuterium-enriched compound of formula I or a pharmaceutically acceptable salt thereof:
wherein the compound is selected from:
or a pharmaceutically acceptable salt thereof, wherein R 1 -R 9 and R 11 -R 29 are independently selected from H and D.
2. A compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt form thereof.
3. A compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt form thereof.
4. A compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt form thereof.
5. A compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt form thereof.
6. A pharmaceutical composition, comprising: a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt form thereof.
7. A pharmaceutical composition of claim 6 , wherein the compound is:
or a pharmaceutically acceptable salt form thereof.
8. A pharmaceutical composition of claim 6 , wherein the compound is:
or a pharmaceutically acceptable salt form thereof.
9. A pharmaceutical composition of claim 6 , wherein the compound is:
or a pharmaceutically acceptable salt form thereof.
10. A pharmaceutical composition of claim 6 , wherein the compound is:
or a pharmaceutically acceptable salt form thereof.
11. A method for treating Alzheimer's disease comprising: administering, to a patient in need thereof, a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt form thereof.
12. A method of claim 11 ; wherein the compound is:
or a pharmaceutically acceptable salt form thereof.
13. A method of claim 11 , wherein the compound is:
or a pharmaceutically acceptable salt form thereof.
14. A method of claim 11 , wherein the compound is:
or a pharmaceutically acceptable salt form thereof.
15. A method of claim 11 , wherein the compound is:
or a pharmaceutically acceptable salt form thereof.