Filter systems including patterned optical analyte sensors and optical readers
A filter system includes a housing, a filter medium disposed within the housing, an optical analyte sensor, and an optical reader. The optical analyte sensor is characterized by a first region that exhibit a first response to an analyte of interest and a second region that exhibit a second, different, response to an analyte of interest. The optical analyte sensor includes a detection medium and is disposed within the housing such that the detection medium is in fluid communication with the filter medium. The optical reader includes at least one light source and at least one detector.
1. A filter system comprising:
a housing;
a filter medium disposed within the housing;
an optical analyte sensor characterized by a first region that exhibits a first response to an analyte of interest and a second region that exhibits a second, different, response to an analyte of interest, the optical analyte sensor comprising a detection medium and disposed within the housing such that the detection medium is in fluid communication with the filter medium; and
an optical reader comprising a first assembly comprising at least one light source and at least one detector and a second assembly comprising at least one light source and at least one detector;
wherein the optical reader is attached to the housing such that at least a portion of light emitted by at least one light source of the first assembly is reflected from the first region of the optical analyte sensor and captured by at least one detector of the first assembly, and at least a portion of light emitted by at least one light source of the second assembly is reflected from the second region of the optical analyte sensor and captured by at least one detector of the second assembly; and,
wherein each of the first and second assemblies comprises first and second light sources and a detector disposed between the first and second light sources and wherein the first and second light sources are characterized by different spectral profiles.
2. The filter system of claim 1 , wherein the housing comprises a removable housing portion and the optical reader is attached to the removable housing portion.
3. The filter system of claim 1 , wherein the optical analyte sensor comprises an occluding layer and the first region corresponds to an area masked by the occluding layer.
4. The filter system of claim 1 , wherein the optical reader comprises at least one registration feature.
5. The filter system of claim 1 , wherein a signal from the detector of the first assembly is compared to a signal from the detector of the second assembly.
6. A filter system comprising:
a housing;
a filter medium disposed within the housing;
an optical analyte sensor characterized by a first region that exhibits a first response to an analyte of interest and a second region that exhibits a second response to the analyte of interest, the optical analyte sensor comprising a detection medium and disposed within the housing such that the detection medium is in fluid communication with the filter medium; and
an optical reader comprising a first assembly comprising a first block, the first block comprising a first light source and a first detector, and a second block, the second block comprising a second light source and a second detector, and a second assembly comprising a light source and a detector;
wherein the optical reader is disposed such that at least a portion of light emitted by the first light source of the first assembly is reflected from a first area of the first region of the optical analyte sensor and captured by the first detector, at least a portion of light emitted by the second light source of the first assembly is reflected from a second, different, area of the first region of the optical analyte sensor and captured by the second detector, and at least a portion of light emitted by at least one light source of the second assembly is reflected from the second region of the optical analyte sensor and captured by at least one detector of the second assembly; and,
wherein each of the first and second blocks comprises first and second light sources and a detector disposed between the first and second light sources and wherein the first and second light sources are characterized by different spectral profiles.
7. The filter assembly of claim 6 , wherein the first assembly comprises a third block, the third block comprising a third light source and a third detector, and wherein the optical reader is disposed such that at least a portion of light emitted by the third light source of the third assembly is reflected from a third area, different from the first and second area, of the first region of the optical analyte sensor and captured by the third detector.
8. The filter system of claim 6 , wherein the housing comprises a removable housing portion and the optical reader is attached to the removable housing portion.
9. The filter system of claim 6 , wherein the optical reader is removably attached to the housing.
10. The filter system of claim 6 , wherein the optical reader comprises at least one registration feature.
11. The filter system of claim 6 , wherein a signal from the detector of the first assembly is compared to a signal from the first and second detectors to a signal from the detector of the second assembly.