IP Library Granted Patent US 9,173,604
Granted Patent B2
US 9,173,604 · App. 13/635,629 · Granted Nov 3, 2015

Measurement device, measurement method, measurement result processing device, measurement system, measurement result processing method, control program, and recording medium

Inventors: Mikihiro Yamanaka (Osaka, JP); Megumi Hijikuro (Osaka, JP); Keita Hara (Osaka, JP)
Assignee: SHARP KABUSHIKI KAISHA
A61B5/1455A61B5/0071A61B5/14546A61B5/743A61B5/489A61B5/6824A61B5/6835A61B2562/185
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Quick Facts
Patent No.
US 9,173,604
App. No.
13/635,629
Granted
Nov 3, 2015
Kind
B2
Abstract

A measurement device ( 1 ) includes a probe ( 7 ) which irradiates a specific part or a specific location of a living body with excitation light and which receives fluorescence generated by irradiating the specific part or the specific location with excitation light.

Claims (41)

1. A measurement system, comprising:

a measurement device for acquiring measurement data of fluorescence generated by irradiating a target measurement part of a living body with excitation light; and

a measurement result processing device which processes the measurement data acquired by the measurement device,

said measurement device including:

a light-shielding section for shielding environment light which is directed toward the target measurement part of the living body;

an excitation light source for irradiating the target measurement part of the living body with excitation light; and

a detector for generating the measurement data by analyzing the fluorescence generated by irradiating the target measurement part with the excitation light, said measurement result processing device including:

a feature extraction section configured to extract a fluorescence characteristic of fluorescence emitted from the target measurement part, which fluorescence is obtained by irradiating, with excitation light, the target measurement part of a living body;

a substance amount specifying section configured to specify an amount of fluorescent substances contained in the target measurement part on the basis of the fluorescence characteristic extracted by the feature extraction section;

a damage degree determination section configured to determine a damage degree indicative of a degree of damage received by the target measurement part or a part of the target measurement part on the basis of the amount of fluorescent substances specified by the substance amount specifying section;

an age calculation section for calculating measurement part age indicative of how aging of the target measurement part progresses on the basis of actual age of the living body and the damage degree of the target measurement part, the actual age being entered to the measurement result processing device, the damage degree being determined by the damage degree determination section; and

a correlation information storage section configured to store first correlation information indicative of a correlation between (I) the actual age of the living body, the average life expectancy, and the damage degree, and (II) the measurement part age,

the age calculation section calculating the measurement part age by use of formula as the first correlation information;

Measurement part age=Average life expectancy−(Average life expectancy/Damage degree)+(Actual age-10).

2. The measurement system as set forth in claim 1 , wherein:

the correlation information storage section further stores second correlation information indicative of a correlation between the amount of fluorescent substances and the damage degree of the target measurement part; and

the damage degree determination section determines the damage degree on the basis of the amount of fluorescent substances by use of the second correlation information.

3. The measurement system as set forth in claim 1 ,

wherein the age calculation section specifies the average life expectancy on the basis of gender and the actual age of the living body, the gender and the actual age being entered to the measurement result processing device.

4. The measurement system as set forth in claim 1 ,

wherein the feature extraction section is configured to extract, as the fluorescence characteristic, a peak fluorescent intensity in a predetermined range of wavelength from a spectrum of fluorescence of the target measurement part obtained by irradiating, with excitation light, the target measurement part.

5. The measurement system as set forth in claim 1 ,

wherein the substance amount specifying section is configured to specify an amount of advanced glycation end products contained in the target measurement part.

6. The measurement system as set forth in claim 1 , further comprising

a display control unit for controlling a display section to display a result of processing carried out by the measurement result processing device.

7. The measurement system as set forth in claim 1 , wherein the target measurement part includes a blood vessel and wherein:

the feature extraction section configured to extract the fluorescence characteristic of the fluorescence emitted from the blood vessel, which fluorescence is obtained by irradiating, with excitation light, the blood vessel of the target measurement part;

the substance amount specifying section configured to specify the amount of fluorescent substances contained in the blood vessel;

the damage degree determination section configured to determine the blood vessel wall damage degree indicative of a degree of damage of a blood vessel wall on the basis of the amount of fluorescent substances in the blood vessel;

the age calculation section configured to calculate a blood vessel age on the basis of the actual age of the living body, the average life expectancy, and the blood vessel wall damage degree; and

the measurement device, further includes:

a blood vessel visualizing light source for visualizing the blood vessel of the target measurement part by irradiating the target measurement part; and

a camera section for capturing the target measurement part irradiated with light of the blood vessel visualizing light source.

8. A measurement result processing method executed by a processor based on measurement data of fluorescence generated by irradiating a target measurement part of a living body with a measurement device, said measurement device including: a light-shielding section for shielding environment light which is directed toward the target measurement part of the living body; an excitation light source for irradiating the target measurement part of the living body with excitation light; and a detector for generating the measurement data by analyzing the fluorescence generated by irradiating the target measurement part with the excitation light, the method comprising:

(I) extracting a fluorescence characteristic in fluorescence from the measurement data;

(II) specifying an amount of fluorescent substances contained in the target measurement part on the basis of the fluorescence characteristic extracted in the step (I);

(III) determining a damage degree indicative of a degree of damage received by the target measurement part or a part of the target measurement part on the basis of the amount of fluorescent substances specified in the step (II);

(IV) calculating measurement part age indicative of how aging of the target measurement part progresses on the basis of actual age of the living body, an average life expectancy specified based on the actual age, and the damage degree of the target measurement part, the actual age being entered to the processor, the damage degree being determined in the step (III); and

storing first correlation information indicative of a correlation between (I) the actual age of the living body, the average life expectancy, and the damage degree, and (II) the measurement part age,

the measurement part age calculation step calculating the measurement part age by use of formula as the first correlation information;

Measurement part age=Average life expectancy−(Average life expectancy/Damage degree)+(Actual age-10).

Assignments (5)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 16, 2025
From: AIR WATER BD INC.
To: AIR WATER INC.
Reel/Frame 072273/0601 →
CHANGE OF NAME Recorded Sep 12, 2025
From: AIR WATER BIODESIGN INC.
To: AIR WATER BD INC.
Reel/Frame 072874/0388 →
CHANGE OF NAME Recorded Sep 5, 2025
From: SHARP LIFE SCIENCE CORPORATION
To: AIR WATER BIODESIGN INC.
Reel/Frame 072851/0484 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 25, 2017
From: SHARP KABUSHIKI KAISHA
To: SHARP LIFE SCIENCE CORPORATION
Reel/Frame 043093/0790 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 4, 2012
From: YAMANAKA, MIKIHIRO; HIJIKURO, MEGUMI; HARA, KEITA
To: SHARP KABUSHIKI KAISHA
Reel/Frame 029075/0490 →
Priority Claims (2)
JP 2010-064572 · Mar 19, 2010 · national
JP 2010-088070 · Apr 6, 2010 · national
Continuity (1)
Related Publication 20130030306A1 · Jan 31, 2013