Granted Patent
B2
US 8,680,271 · App. 13/637,187 · Granted Mar 25, 2014
Process for synthesizing 6-bromo-3-1-(1-methyl-1H-pyrazol-4-yl)-5-(3(R)-piperidinyl)pyrazolo[1,5-a]pyrimidin-7-amine
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Abstract
A process for the preparation of the compound of Formula (I) is described.
Claims (8)
1. A process for preparing the compound of Formula I
comprising:
1) treating the compound of Formula A with alcoholic HCl for about 30 minutes-4 hrs at about 25-70° C.;
2) adjusting the pH to about 10-11 using KOH;
3) adding ethanol, and heating to a temperature of 50-80° C. for about 10-120 minutes;
4) cooling to below reflux;
5) optionally seeding with the compound of Formula I; and
6) isolating the compound of Formula I.
Assignments (1)
MERGER
Recorded Aug 8, 2022
From: MERCK SHARP & DOHME CORP.
To: MERCK SHARP & DOHME LLC
Reel/Frame 061102/0145 →