IP Library Granted Patent US 8,680,271
Granted Patent B2
US 8,680,271 · App. 13/637,187 · Granted Mar 25, 2014

Process for synthesizing 6-bromo-3-1-(1-methyl-1H-pyrazol-4-yl)-5-(3(R)-piperidinyl)pyrazolo[1,5-a]pyrimidin-7-amine

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Quick Facts
Patent No.
US 8,680,271
App. No.
13/637,187
Granted
Mar 25, 2014
Kind
B2
Abstract

A process for the preparation of the compound of Formula (I) is described.

Claims (8)

1. A process for preparing the compound of Formula I

comprising:

1) treating the compound of Formula A with alcoholic HCl for about 30 minutes-4 hrs at about 25-70° C.;

2) adjusting the pH to about 10-11 using KOH;

3) adding ethanol, and heating to a temperature of 50-80° C. for about 10-120 minutes;

4) cooling to below reflux;

5) optionally seeding with the compound of Formula I; and

6) isolating the compound of Formula I.

Assignments (1)
MERGER Recorded Aug 8, 2022
From: MERCK SHARP & DOHME CORP.
To: MERCK SHARP & DOHME LLC
Reel/Frame 061102/0145 →