Broad spectrum antiviral and antiparasitic agents
The invention provides compounds represented by the formulae: (I) and (II) where the compounds are useful in treating, for example, viral and/or parasitic infections. Also provided are pharmaceutical compositions comprising the compounds and methods of treatment using the compounds.
1. A compound according to formula Ia or a pharmaceutically acceptable salt thereof,
wherein R 1 is H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, C 3 -C 6 aryl, C 3 -C 6 heteroaryl, C 3 -C 6 cycloalkyl, or C 3 -C 6 heterocycloalkyl, each optionally substituted with halo, —NO 2 , —CF 3 , —CN, —OR 3 , —SR 3 , —C(O)R 3 , —NHC(O)R 3 , —C(O)OR 3 , —OC(O)R 3 , —NR 4 R 5 , —C(O)NR 4 R 5 , —NHR 3 C(O)NR 4 R 5 , or —SO 2 NR 4 R 5 ;
R 2 represents one or more substituents independently selected from —OR 3 , —SR 3 , and —NR 4 R 5 ;
R 3 , R 4 , and R 5 are independently H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; and
X is O, N, S, NH, or NR 3 .
2. The compound claim 1 , wherein R 1 is C 1 -C 6 alkyl.
3. A pharmaceutical composition comprising the compound of claim 1 and at least one pharmaceutically acceptable excipient.
4. The pharmaceutical composition of claim 3 , wherein the composition is suitable as a topical formulation.
5. The pharmaceutical composition of claim 4 , which is in the form of a patch, an ointment, a cream, a lotion, a drop, a spray, or an aerosol.
6. The pharmaceutical composition of claim 4 , which is in the form of a liposomal formulation.
7. The compound of claim 1 having formula:
8. The compound of claim 1 having formula:
9. The compound of claim 1 having formula: