ANTI-ABUSE GELLED PHARMACEUTICAL COMPOSITIONS
This invention provides an oral pharmaceutical composition comprising a physiologically tolerable gelled oil-in-water emulsion containing a drug of abuse.
1 . An oral pharmaceutical composition comprising a physiologically tolerable gelled oil-in-water emulsion containing a drug of abuse.
2 . A method of treatment of a mammalian subject (either human or non-human) by oral administration to said subject of an effective amount of a drug substance which is a drug of abuse, the improvement comprising administering said drug substance in a physiologically tolerable gelled oil-in-water emulsion.
3 . A pharmaceutical composition comprising a physiologically tolerable gelled oil-in-water emulsion containing a drug of abuse, for use in medicine.
4 . A pharmaceutical composition comprising a physiologically tolerable gelled oil-in-water emulsion containing a drug of abuse, for use in treatment by oral administration of a condition responsive to said drug of abuse.
5 . The use of a drug of abuse for the manufacture of a medicament for use by oral administration in the treatment of a condition responsive to said drug of abuse.
6 . A composition, use or method as claimed in any of the preceding claims wherein said drug of abuse is an opioid, CNS depressant, or stimulant.
7 . A composition, use or method as claimed in any of the preceding claims wherein said drug of abuse is selected from the group consisting of codeine, morphine, hydrocodone, oxycodone, diamorphine, pethidine, tramadol, buprenorphine, propoxyphene, hydromorphone, meperidine, diphenoxylate, barbiturates (e.g. pentobarbital sodium), benzodiazepines (e.g. diazepam, alprazolam and flunitrazepam), amphetamines (e.g. amphetamine, dextroamphetamine, l-lysine-d-amphetamine), methyl phenidate, zolpidem, methadone, mephedrone, tetrahydrocannabinol, ketamine, clonidine, mexiletine, and tapentadol.