IP Library › Granted Patent US 8,969,346

Granted Patent B2

US 8,969,346 · App. 13/642,207 · Granted Mar 3, 2015

Amino-pyridazine skeletal muscle modulators

Inventors: Luke W. Ashcraft (San Francisco, CA); Gustave Bergnes (Pacifica, CA); Scott Collibee (San Carlos, CA); Chihyuan Chuang (Millbrae, CA); Jeff Gardina (South San Francisco, CA); Bradley P. Morgan (Moraga, CA); Alex R. Muci (San Francisco, CA); Xiangping Qian (Foster City, CA); Jeffrey M Warrington (San Mateo, CA); Zhe Yang (Daly City, CA); Pu-Ping Lu (Foster City, CA); Antonio Romero (San Mateo, CA)

Assignee: Cytokinetics, Inc.

C07D401/12 A61K31/50 C07D237/20 C07D237/24 C07D401/04 C07D403/04 C07D403/06 C07D409/14 C07D411/04 C07D413/04 C07D413/14 C07D417/14 C07D487/04 C07D487/10 C07D513/04 C07D401/14 C07D405/14

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Quick Facts

Patent No.: US 8,969,346
App. No.: 13/642,207
Granted: Mar 3, 2015
Kind: B2

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Abstract

Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , X and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.

Claims (687)

1. A compound of Formula I:

or a pharmaceutically acceptable salt thereof, wherein:

R 1 is selected from hydrogen, halogen, CN, C 1-6 alkyl, C 1-6 haloalkyl, C(O)OR a , C(O)NR b R c , OR a , NR b R c , C 6-10 aryl and 5-10 membered heteroaryl;

R 2 is selected from C 6-10 aryl and 5-10 membered heteroaryl each optionally substituted with 1, 2, 3, 4 or 5 substituents selected from halogen, CN, oxo, (CH 2 ) n OR a , (CH 2 ) n OC(O)R a , (CH 2 ) n OC(O)OR a , (CH 2 ) n OC(O)NR b R c , (CH 2 ) n NR b R c , (CH 2 ) n NR d C(O)R a , (CH 2 ) n NR d C(O)OR a , (CH 2 ) n NR d C(O)NR b R c , (CH 2 ) n NR d C(O)C(O)NR b R c , (CH 2 ) n NR d C(S)R a , (CH 2 ) n NR d C(S)OR a , (CH 2 ) n NR d C(S)NR b R c , (CH 2 ) n NR d C(NR e )NR b R c , (CH 2 ) n NR d S(O)R a , (CH 2 ) n NR d SO 2 R a , (CH 2 ) n NR d SO 2 NR b R c , (CH 2 ) n C(O)R a , (CH 2 ) n C(O)OR a , (CH 2 ) n C(O)NR b R c , (CH 2 ) n C(S)R a , (CH 2 ) n C(S)OR a , (CH 2 ) n C(S)NR b R c , (CH 2 ) n C(NR e )NR b R c , (CH 2 ) n SR a , (CH 2 ) n S(O)R a , (CH 2 ) n SO 2 R a , (CH 2 ) n SO 2 NR b R c , C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, (CH 2 ) n C 3-8 cycloalkyl, (CH 2 ) n 3-8 membered heterocycloalkyl, (CH 2 ) n C 6-10 aryl and (CH 2 ) n 5-10 membered heteroaryl, wherein each of the C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, (CH 2 ) n C 3-8 cycloalkyl, (CH 2 ) n 3-8 membered heterocycloalkyl, (CH 2 ) n C 6-10 aryl and (CH 2 ) n 5-10 membered heteroaryl groups is optionally substituted with 1, 2, 3, 4 or 5 R f substituents;

R 3 is selected from hydrogen, halogen, CN, C 1-6 alkyl, C 1-6 haloalkyl, C(O)OR a , C(O)NR b R c , OR a , NR b R c , C 6-10 aryl and 5-10 membered heteroaryl;

R 4 is selected from hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C(O)R a , C(O)OR a , C(O)NR b R c and SO 2 R a ;

R 5 and R 6 together with the carbon atom to which they are bound form a group selected from C 3-8 cycloalkyl, C 3-8 cycloalkenyl, 3-8 membered heterocycloalkyl and 3-8 membered heterocycloalkenyl, each optionally substituted with 1, 2, 3, 4 or 5 substituents selected from halogen, CN, oxo, OR a , OC(O)R a , OC(O)OR a , NR b R c , C(O)R a , C(O)OR a , C(O)NR b R c , S(O)R a , SO 2 R a , SO 2 NR b R c , C 1-6 alkyl and C 1-6 haloalkyl;

R 7 is selected from C 6-10 aryl and 5-10 membered heteroaryl, each optionally substituted with 1, 2, 3, 4 or 5 substituents selected from halogen, CN, oxo, OR a , OC(O)R a , OC(O)OR a , OC(O)NR b R c , NR b R c , NR d C(O)R a , NR d C(O)OR a , NR d C(O)NR b R c , NR d C(O)C(O)NR b R c , NR d C(S)R a , NR d C(S)OR a , NR d C(S)NR b R c , NR d C(NR e )NR b R c , NR d S(O)R a , NR d SO 2 R a , NR d SO 2 NR b R c , C(O)R a , C(O)OR a , C(O)NR b R c , C(S)R a , C(S)OR a , C(S)NR b R c , C(NR e )NR b R c , SR a , S(O)R a , SO 2 R a , SO 2 NR b R c , C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C 6-10 aryl, C 7-11 aralkyl, and 5-10 membered heteroaryl, wherein each of the C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C 6-10 aryl, C 7-11 aralkyl and 5-10 membered heteroaryl groups is optionally substituted with 1, 2, 3, 4 or 5 R f substituents;

R 8 and R 9 , at each occurrence, are each independently selected from hydrogen, halogen and C 1-6 alkyl;

X is a bond;

R a , at each occurrence, is independently selected from hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C 6-10 aryl, C 7-11 aralkyl and 5-10 membered heteroaryl, wherein each of the C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C 6-10 aryl, C 7-11 aralkyl and 5-10 membered heteroaryl groups is optionally substituted with 1, 2, 3, 4 or 5 R f substituents;

R b and R c , at each occurrence, are each independently selected from hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C 6-10 aryl, C 7-11 aralkyl, 5-10 membered heteroaryl, C(O)R g , C(O)OR g , C(O)NR i R j and SO 2 R g , wherein each of the C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C 6-10 aryl, C 7-11 aralkyl and 5-10 membered heteroaryl groups is optionally substituted with 1, 2, 3, 4 or 5 R f substituents;

R d , at each occurrence, is independently selected from hydrogen and C 1-6 alkyl;

R e , at each occurrence, is independently selected from hydrogen, CN, OH, C 1-6 alkoxy, C 1-6 alkyl and C 1-6 haloalkyl;

R f , at each occurrence, is independently selected from halogen, CN, OR h , OC(O)R h , OC(O)OR h , OC(O)NR i R j , NR d C(O)R h , NR d C(O)OR h , NR d C(O)NR i R j , NR d C(O)C(O)NR i R j , NR d C(S)R h , NR d C(S)OR h , NR d C(S)NR i R j , NR d C(NR e )NR i R j , NR d S(O)R h , NR d SO 2 R h , NR d SO 2 NR i R j , C(O)R h , C(O)OR h , C(O)NR i R j , C(S)R h , C(S)OR h , C(S)NR i R j , C(NR e )NR i R j , SR h , S(O)R h , SO 2 R h , SO 2 NR i R j , C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C 6-10 aryl, C 7-11 aralkyl and 5-10 membered heteroaryl, wherein each of the C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C 6-10 aryl, C 7-11 aralkyl and 5-10 membered heteroaryl groups is optionally substituted with 1, 2, 3, 4 or 5 R k substituents;

or two R f substituents bound to a single carbon atom, together with the carbon atom to which they are both bound, form a group selected from oxo, C 3-8 cycloalkyl and 3-8 membered heterocycloalkyl;

R g , at each occurrence, is independently selected from C 1-6 alkyl, C 1-6 haloalkyl, phenyl, naphthyl, and C 7-11 aralkyl, each optionally substituted with 1, 2, 3, 4 or 5 substituents selected from halogen, CN, OH, C 1-6 alkoxy, C 1-6 alkyl and C 1-6 haloalkyl;

R h , at each occurrence, is independently selected from hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C 6-10 aryl, C 7-11 aralkyl and 5-10 membered heteroaryl, wherein each of the C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C 6-10 aryl, C 7-11 aralkyl and 5-10 membered heteroaryl groups is optionally substituted with 1, 2, 3, 4 or 5 R k substituents;

R i and R j , at each occurrence, are each independently selected from hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C 6-10 aryl, C 7-11 aralkyl, 5-10 membered heteroaryl, C(O)R g , and C(O)OR g , wherein each of the C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C 6-10 aryl, C 7-11 aralkyl and 5-10 membered heteroaryl groups is optionally substituted with 1, 2, 3, 4 or 5 substituents selected from halogen, CN, OH, C 1-6 alkoxy, C 1-6 alkyl and C 1-6 haloalkyl;

R k , at each occurrence, is independently selected from halogen, CN, OH, C 1-6 alkoxy, NH 2 , NH(C 1-6 alkyl), N(C 1-6 alkyl) 2 , NHC(O)C 1-6 alkyl, NHC(O)C 7-11 aralkyl, NHC(O)OC 1-6 alkyl, NHC(O)OC 7-11 aralkyl, OC(O)C 1-6 alkyl, OC(O)C 7-11 aralkyl, OC(O)OC 1 -6 alkyl, OC(O)OC 7-11 aralkyl, C(O)C 1-6 alkyl, C(O)C 7-11 aralkyl, C(O) OC 1-6 alkyl, C(O)OC 7-11 aralkyl, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, and C 2-6 alkynyl, wherein each C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, and C 7-11 aralkyl substituent is optionally substituted with 1, 2 or 3 substituents selected from OH, C 1-6 alkoxy, NH 2 , NH(C 1-6 alkyl), N(C 1-6 alkyl) 2 , NHC(O)C 1-6 alkyl, NHC(O)C 7-11 aralkyl, NHC(O)OC 1-6 alkyl, and NHC(O)OC 7-11 aralkyl;

or two R k substituents bound to a single carbon atom, together with the carbon atom to which they are both bound, form a oxo group;

m is 0, 1 or 2;

n, at each occurrence, independently is 0, 1 or 2;

p is 0, 1 or 2; and

q is 0, 1 or 2.

2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 5 and R 6 together with the carbon atom to which they are bound form C 3-8 cycloalkyl optionally substituted with 1, 2, 3, 4 or 5 substituents selected from halogen, CN, oxo, OR a , OC(O)R a , OC(O)OR a , NR b R c , C(O)R a , C(O)OR a , C(O)NR b R c , S(O)R a , SO 2 R a , SO 2 NR b R c , C 1-6 alkyl and C 1-6 haloalkyl.

3. The compound of claim 2 , or a pharmaceutically acceptable salt thereof, wherein R 5 and R 6 together with the carbon atom to which they are bound form a group selected from cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl, each optionally substituted with 1, 2, 3, 4 or 5 substituents selected from halogen, CN, oxo, OR a , OC(O)R a , OC(O)OR a , NR b R c , C(O)R a , C(O)OR a , C(O)NR b R c , S(O)R a , SO 2 R a , SO 2 NR b R c , C 1-6 alkyl and C 1-6 haloalkyl.

4. The compound of claim 3 , or a pharmaceutically acceptable salt thereof, wherein R 5 and R 6 together with the carbon atom to which they are bound form cyclobutyl optionally substituted with 1, 2, 3, 4 or 5 substituents selected from halogen, CN, oxo, OR a , OC(O)R a , OC(O)OR a , NR b R c , C(O)R a , C(O)OR a , C(O)NR b R c , S(O)R a , SO 2 R a , SO 2 NR b R c , C 1-6 alkyl and C 1-6 haloalkyl.

5. The compound of claim 4 , or a pharmaceutically acceptable salt thereof, wherein R 5 and R 6 together with the carbon atom to which they are bound form cyclobutyl optionally substituted with one or two halogens.

6. The compound of claim 5 , or a pharmaceutically acceptable salt thereof, wherein R 5 and R 6 together with the carbon atom to which they are bound form a group selected from cyclobutyl, 3-fluorocyclobutyl and 3,3-difluorocyclobutyl.

7. The compound of claim 4 , wherein the compound is of Formula V(a) or Formula V(b), or a pharmaceutically acceptable salt thereof:

wherein R m and R n are each independently selected from hydrogen, halogen and C 1-6 alkyl.

8. The compound of claim 7 , wherein one of R m and R n is hydrogen and the other is halogen.

9. The compound of claim 8 , wherein the halogen and R 7 are in a trans configuration with respect to one another on the cyclobutyl ring.

10. The compound of claim 8 , wherein the halogen and R 7 are in a cis configuration with respect to one another on the cyclobutyl ring.

11. The compound of claim 7 , wherein one of R m and R n is hydrogen and the other is fluorine.

12. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 2 is 5-10 membered heteroaryl optionally substituted with 1, 2, 3, 4 or 5 substituents selected from halogen, CN, oxo, (CH 2 ) n OR a , (CH 2 ) n OC(O)R a , (CH 2 ) n OC(O)OR a , (CH 2 ) n OC(O)NR b R c , (CH 2 ) n NR b R c , (CH 2 ) n NR d C(O)R a , (CH 2 ) n NR d C(O)OR a , (CH 2 ) n NR d C(O)NR b R c , (CH 2 ) n NR d C(O)C(O)NR b R c , (CH 2 ) n NR d C(S)R a , (CH 2 ) n NR d C(S)OR a , (CH 2 ) n NR d C(S)NR b R c , (CH 2 ) n NR d C(NR e )NR b R c , (CH 2 ) n NR d S(O)R a , (CH 2 ) n NR d SO 2 R a , (CH 2 ) n NR d SO 2 NR b R c , (CH 2 ) n C(O)R a , (CH 2 ) n C(O)OR a , (CH 2 ) n C(O)NR b R c , (CH 2 ) n C(S)R a , (CH 2 ) n C(S)OR a , (CH 2 ) n C(S)NR b R c , (CH 2 ) n C(NR e )NR b R c , (CH 2 ) n SR a , (CH 2 ) n S(O)R a , (CH 2 ) n SO 2 R a , (CH 2 ) n SO 2 NR b R c , C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, (CH 2 ) n C 3-8 cycloalkyl, (CH 2 ) n 3-8 membered heterocycloalkyl, (CH 2 ) n phenyl, (CH 2 ) n naphthyl and (CH 2 ) n 5-10 membered heteroaryl, wherein each of the C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, (CH 2 ) n C 3-8 cycloalkyl, (CH 2 ) n 3-8 membered heterocycloalkyl, (CH 2 ) n phenyl, (CH 2 ) n naphthyl and (CH 2 ) n 5-10 membered heteroaryl groups is optionally substituted with 1, 2, 3, 4 or 5 R f substituents.

13. The compound of claim 12 , or a pharmaceutically acceptable salt thereof, wherein R 2 is selected from pyridyl, pyrimidyl, pyrazyl, pyridazyl, triazyl, furanyl, pyrrolyl, thiophenyl, thiazolyl, isothiazolyl, thiadiazolyl, oxazolyl, isoxazolyl, oxadiazolyl, imidazolyl, triazolyl and tetrazolyl, each optionally substituted with 1, 2, 3 or 4 substituents selected from halogen, CN, oxo, (CH 2 ) n OR a , (CH 2 ) n OC(O)R a , (CH 2 ) n OC(O)OR a , (CH 2 ) n OC(O)NR b R c , (CH 2 ) n NR b R c , (CH 2 ) n NR d C(O)R a , (CH 2 ) n NR d C(O)OR a , (CH 2 ) n NR d C(O)NR b R c , (CH 2 ) n NR d C(O)C(O)NR b R c , (CH 2 ) n NR d C(S)R a , (CH 2 ) n NR d C(S)OR a , (CH 2 ) n NR d C(S)NR b R c , (CH 2 ) n NR d C(NR e )NR b R c , (CH 2 ) n NR d S(O)R a , (CH 2 ) n NR d SO 2 R a , (CH 2 ) n NR d SO 2 NR b R c , (CH 2 ) n C(O)R a , (CH 2 ) n C(O)OR a , (CH 2 ) n C(O)NR b R c , (CH 2 ) n C(S)R a , (CH 2 ) n C(S)OR a , (CH 2 ) n C(S)NR b R c , (CH 2 ) n C(NR e )NR b R c , (CH 2 ) n SR a , (CH 2 ) n S(O)R a , (CH 2 ) n SO 2 R a , (CH 2 ) n SO 2 NR b R c , C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, (CH 2 ) n C 3-8 cycloalkyl, (CH 2 ) n 3-8 membered heterocycloalkyl, (CH 2 ) n phenyl, (CH 2 ) n naphthyl and (CH 2 ) n 5-10 membered heteroaryl, wherein each of the C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, (CH 2 ) n C 3-8 cycloalkyl, (CH 2 ) n 3-8 membered heterocycloalkyl, (CH 2 ) n phenyl, (CH 2 ) n naphthyl and (CH 2 ) n 5-10 membered heteroaryl groups is optionally substituted with 1, 2, 3, 4 or 5 R f substituents.

14. The compound of claim 13 , or a pharmaceutically acceptable salt thereof, wherein R 2 is selected from pyridyl, pyrimidyl, pyrazyl, pyridazyl, triazyl, furanyl, pyrrolyl, thiophenyl, thiazolyl, isothiazolyl, thiadiazolyl, oxazolyl, isoxazolyl, oxadiazolyl, imidazolyl, triazolyl and tetrazolyl, each optionally substituted with a substituent selected from (CH 2 ) n C(O)OR a and (CH 2 ) n C(O)NR b R c ; and optionally substituted with 1, 2 or 3 additional substituents selected from halogen, CN, oxo, (CH 2 ) n OR a , (CH 2 ) n OC(O)R a , (CH 2 ) n OC(O)OR a , (CH 2 ) n OC(O)NR b R c , (CH 2 ) n NR b R c , (CH 2 ) n NR d C(O)R a , (CH 2 ) n NR d C(O)OR a , (CH 2 ) n NR d C(O)NR b R c , (CH 2 ) n NR d C(O)C(O)NR b R c , (CH 2 ) n NR d C(S)R a , (CH 2 ) n NR d C(S)OR a , (CH 2 ) n NR d C(S)NR b R c , (CH 2 ) n NR d C(NR e )NR b R c , (CH 2 ) n NR d S(O)R a , (CH 2 ) n NR d SO 2 R a , (CH 2 ) n NR d SO 2 NR b R c , (CH 2 ) n C(O)R a , (CH 2 ) n C(O)OR a , (CH 2 ) n C(O)NR b R c , (CH 2 ) n C(S)R a , (CH 2 ) n C(S)OR a , (CH 2 ) n C(S)NR b R c , (CH 2 ) n C(NR e )NR b R c , (CH 2 ) n SR a , (CH 2 ) n S(O)R a , (CH 2 ) n SO 2 R a , (CH 2 ) n SO 2 NR b R c , C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, (CH 2 ) n C 3-8 cycloalkyl, (CH 2 ) n 3-8 membered heterocycloalkyl, (CH 2 ) n phenyl, (CH 2 ) n naphthyl and (CH 2 ) n 5-10 membered heteroaryl, wherein each of the C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, (CH 2 ) n C 3-8 cycloalkyl, (CH 2 ) n 3-8 membered heterocycloalkyl, (CH 2 ) n phenyl, (CH 2 ) n naphthyl and (CH 2 ) n 5-10 membered heteroaryl groups is optionally substituted with 1, 2, 3, 4 or 5 R f substituents.

15. The compound of claim 14 , or a pharmaceutically acceptable salt thereof, wherein R 2 is selected from furanyl, pyrrolyl, thiophenyl, thiazolyl, isothiazolyl, thiadiazolyl, oxazolyl, isoxazolyl, oxadiazolyl, imidazolyl, triazolyl and tetrazolyl, each optionally substituted with (CH 2 ) n C(O)NR b R c .

16. The compound of claim 13 , or a pharmaceutically acceptable salt thereof, wherein R 2 is selected from pyridyl, pyrimidyl, pyrazyl, pyridazyl, triazyl, furanyl, pyrrolyl, thiophenyl, thiazolyl, isothiazolyl, thiadiazolyl, oxazolyl, isoxazolyl, oxadiazolyl, imidazolyl, triazolyl and tetrazolyl, each optionally substituted with (CH 2 ) n NR d C(O)R a , wherein R a is C 1-6 alkyl or 3-8 membered heterocycloalkyl, each optionally substituted with 1, 2 or 3 additional substituents selected from halogen, CN, oxo, (CH 2 ) n OR a , (CH 2 ) n OC(O)R a , (CH 2 ) n OC(O)OR a , (CH 2 ) n OC(O)NR b R c , (CH 2 ) n NR b R c , (CH 2 ) n NR d C(O)R a , (CH 2 ) n NR d C(O)OR a , (CH 2 ) n NR d C(O)NR b R c , (CH 2 ) n NR d C(O)C(O)NR b R c , (CH 2 ) n NR d C(S)R a , (CH 2 ) n NR d C(S)OR a , (CH 2 ) n NR d C(S)NR b R c , (CH 2 ) n NR d C(NR e )NR b R c , (CH 2 ) n NR d S(O)R a , (CH 2 ) n NR d SO 2 R a , (CH 2 ) n NR d SO 2 NR b R c , (CH 2 ) n C(O)R a , (CH 2 ) n C(O)OR a , (CH 2 ) n C(O)NR b R c , (CH 2 ) n C(S)R a , (CH 2 ) n C(S)OR a , (CH 2 ) n C(S)NR b R c , (CH 2 ) n C(NR e )NR b R c , (CH 2 ) n SR a , (CH 2 ) n S(O)R a , (CH 2 ) n SO 2 R a , (CH 2 ) n SO 2 NR b R c , C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, (CH 2 ) n C 3-8 cycloalkyl, (CH 2 ) n 3-8 membered heterocycloalkyl, (CH 2 ) n phenyl, (CH 2 ) n naphthyl and (CH 2 ) n 5-10 membered heteroaryl, wherein each of the C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, (CH 2 ) n C 3-8 cycloalkyl, (CH 2 ) n 3-8 membered heterocycloalkyl, (CH 2 ) n phenyl, (CH 2 ) n naphthyl and (CH 2 ) n 5-10 membered heteroaryl groups is optionally substituted with 1, 2, 3, 4 or 5 R f substituents.

17. The compound of claim 16 , or a pharmaceutically acceptable salt thereof, wherein R 2 is selected from furanyl, pyrrolyl, thiophenyl, thiazolyl, isothiazolyl, thiadiazolyl, oxazolyl, isoxazolyl, oxadiazolyl, imidazolyl, triazolyl and tetrazolyl, each optionally substituted with (CH 2 ) n NR d C(O)R a , wherein R a is selected from C 1-6 alkyl, C 1-6 alkyl-OH and C 1-6 alkyl-NH 2 , each optionally substituted with 1, 2 or 3 additional substituents selected from halogen, CN, (CH 2 ) n OR a , (CH 2 ) n OC(O)R a , (CH 2 ) n OC(O)OR a , (CH 2 ) n OC(O)NR b R c , (CH 2 ) n NR b R c , (CH 2 ) n NR d C(O)R a , (CH 2 ) n NR d C(O)OR a , (CH 2 ) n NR d C(O)NR b R c , (CH 2 ) n NR d SO 2 R a , (CH 2 ) n NR d SO 2 NR b R c , (CH 2 ) n C(O)R a , (CH 2 ) n C(O)OR a , (CH 2 ) n C(O)NR b R c , (CH 2 ) n SR a , (CH 2 ) n S(O)R a , (CH 2 ) n SO 2 R a , (CH 2 ) n SO 2 NR b R c , C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, (CH 2 ) n C 3-8 cycloalkyl, (CH 2 ) n 3-8 membered heterocycloalkyl, (CH 2 ) n phenyl, (CH 2 ) n naphthyl and (CH 2 ) n 5-10 membered heteroaryl.

18. The compound of claim 12 , or a pharmaceutically acceptable salt thereof, wherein R 2 is selected from indolyl, indazolyl, benzimidazolyl, benzoxazolyl and benzoisoxazolyl, each optionally substituted with 1, 2, 3 or 4 substituents selected from halogen, CN, oxo, (CH 2 ) n OR a , (CH 2 ) n OC(O)R a , (CH 2 ) n OC(O)OR a , (CH 2 ) n OC(O)NR b R c , (CH 2 ) n NR b R c , (CH 2 ) n NR d C(O)R a , (CH 2 ) n NR d C(O)OR a , (CH 2 ) n NR d C(O)NR b R c , (CH 2 ) n NR d C(O)C(O)NR b R c , (CH 2 ) n NR d C(S)R a , (CH 2 ) n NR d C(S)OR a , (CH 2 ) n NR d C(S)NR b R c , (CH 2 ) n NR d C(NR e )NR b R c , (CH 2 ) n NR d S(O)R a , (CH 2 ) n NR d SO 2 R a , (CH 2 ) n NR d SO 2 NR b R c , (CH 2 ) n C(O)R a , (CH 2 ) n C(O)OR a , (CH 2 ) n C(O)NR b R c , (CH 2 ) n C(S)R a , (CH 2 ) n C(S)OR a , (CH 2 ) n C(S)NR b R c , (CH 2 ) n C(NR e )NR b R c , (CH 2 ) n SR a , (CH 2 ) n S(O)R a , (CH 2 ) n SO 2 R a , (CH 2 ) n SO 2 NR b R c , C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, (CH 2 ) n C 3-8 cycloalkyl, (CH 2 ) n 3-8 membered heterocycloalkyl, (CH 2 ) n phenyl, (CH 2 ) n naphthyl and (CH 2 ) n 5-10 membered heteroaryl, wherein each of the C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, (CH 2 ) n C 3-8 cycloalkyl, (CH 2 ) n 3-8 membered heterocycloalkyl, (CH 2 ) n phenyl, (CH 2 ) n naphthyl and (CH 2 ) n 5-10 membered heteroaryl groups is optionally substituted with 1, 2, 3, 4 or 5 R f substituents.

19. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 7 is 5-10 membered heteroaryl optionally substituted with 1, 2, 3, 4 or 5 substituents selected from halogen, CN, oxo, OR a , OC(O)R a , OC(O)OR a , OC(O)NR b R c , NR b R c , NR d C(O)R a , NR d C(O)OR a , NR d C(O)NR b R c , NR d C(O)C(O)NR b R c , NR d C(S)R a , NR d C(S)OR a , NR d C(S)NR b R c , NR d C(NR e )NR b R c , NR d S(O)R a , NR d SO 2 R a , NR d SO 2 NR b R c , C(O)R a , C(O)OR a , C(O)NR b R c , C(S)R a , C(S)OR a , C(S)NR b R c , C(NR e )NR b R c , SR a , S(O)R a , SO 2 R a , SO 2 NR b R c , C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C 6-10 aryl, C 7-11 aralkyl, and 5-10 membered heteroaryl, wherein each of the C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C 6-10 aryl, C 7-11 aralkyl and 5-10 membered heteroaryl groups is optionally substituted with 1, 2, 3, 4 or 5 R f substituents.

20. The compound of claim 19 , or a pharmaceutically acceptable salt thereof, wherein R 7 is pyridyl optionally substituted with 1, 2, 3, 4 or 5 substituents selected from halogen, CN, oxo, OR a , OC(O)R a , OC(O)OR a , OC(O)NR b R c , NR b R c , NR d C(O)R a , NR d C(O)OR a , NR d C(O)NR b R c , NR d C(O)C(O)NR b R c , NR d C(S)R a , NR d C(S)OR a , NR d C(S)NR b R c , NR d C(NR e )NR b R c , NR d S(O)R a , NR d SO 2 R a , NR d SO 2 NR b R c , C(O)R a , C(O)OR a , C(O)NR b R c , C(S)R a , C(S)OR a , C(S)NR b R c , C(NR e )NR b R c , SR a , S(O)R a , SO 2 R a , SO 2 NR b R c , C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 3-6 cycloalkenyl, 3-6 membered heterocycloalkyl, 3-6 membered heterocycloalkenyl, phenyl, naphthyl, C 7-11 aralkyl, and 5-10 membered heteroaryl, wherein each of the C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C 6-10 aryl, C 7-11 aralkyl and 5-10 membered heteroaryl groups is optionally substituted with 1, 2, 3, 4 or 5 R f substituents.

21. The compound of claim 20 , or a pharmaceutically acceptable salt thereof, wherein R 7 is 2-pyridyl optionally substituted with 1, 2, 3, 4 or 5 substituents selected from halogen, CN, oxo, OR a , OC(O)R a , OC(O)OR a , OC(O)NR b R c , NR b R c , NR d C(O)R a , NR d C(O)OR a , NR d C(O)NR b R c , NR d C(O)C(O)NR b R c , NR d C(S)R a , NR d C(S)OR a , NR d C(S)NR b R c , NR d C(NR e )NR b R c , NR d S(O)R a , NR d SO 2 R a , NR d SO 2 NR b R c , C(O)R a , C(O)OR a , C(O)NR b R c , C(S)R a , C(S)OR a , C(S)NR b R c , C(NR e )NR b R c , SR a , S(O)R a , SO 2 R a , SO 2 NR b R c , C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, C 3-6 cycloalkenyl, 3-6 membered heterocycloalkyl, 3-6 membered heterocycloalkenyl, phenyl, naphthyl, C 7-11 aralkyl, and 5-10 membered heteroaryl, wherein each of the C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C 6-10 aryl, C 7-11 aralkyl and 5-10 membered heteroaryl groups is optionally substituted with 1, 2, 3, 4 or 5 R f substituents.

22. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein m is 1.

23. The compound of claim 22 , wherein R 8 and R 9 are each hydrogen.

24. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is selected from hydrogen, halogen, CN, CF 3 and methyl.

25. The compound of claim 24 , or a pharmaceutically acceptable salt thereof, wherein R 1 is hydrogen.

26. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 3 is selected from hydrogen, halogen, CN, CF 3 and methyl.

27. The compound of claim 26 , or a pharmaceutically acceptable salt thereof, wherein R 3 is hydrogen.

28. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein:

m is 0;

R 2 is selected from phenyl and 5-10 membered heteroaryl optionally substituted with 1, 2, 3, 4 or 5 substituents selected from halogen, CN, oxo, (CH 2 ) n OR a , (CH 2 ) n NR b R c , (CH 2 ) n NR d C(O)R a , (CH 2 ) n NR d C(O)OR a , (CH 2 ) n NR d C(O)NR b R c , (CH 2 ) n NR d S(O)R a , (CH 2 ) n NR d SO 2 R a , (CH 2 ) n NR d SO 2 NR b R c , (CH 2 ) n C(O)R a , (CH 2 ) n C(O)OR a , (CH 2 ) n C(O)NR b R c , (CH 2 ) n SR a , (CH 2 ) n S(O)R a , (CH 2 ) n SO 2 R a , (CH 2 ) n SO 2 NR b R c , C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, and C 2-6 alkynyl, wherein each of the C 1-6 alkyl, C 2-6 alkenyl, and C 2-6 alkynyl groups is optionally substituted with 1, 2, 3, 4 or 5 R f substituents;

R 4 is hydrogen;

R 5 and R 6 together with the carbon atom to which they are bound form cyclobutyl optionally substituted with one or two halogens; and

R 7 is selected from phenyl and pyridyl, each optionally substituted with 1, 2 or 3 substituents selected from halogen, CN, OR a , SR a , S(O)R a , SO 2 R a , SO 2 NR b R c , C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, and C 2-6 alkynyl.

29. The compound of claim 28 , or a pharmaceutically acceptable salt thereof, wherein R 1 is hydrogen and R 3 is hydrogen.

30. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein:

m is 1;

R 4 is hydrogen;

R 5 and R 6 together with the carbon atom to which they are bound form cyclobutyl optionally substituted with one or two halogens;

R 8 is hydrogen; and

R 9 is hydrogen.

31. The compound of claim 30 , or a pharmaceutically acceptable salt thereof, wherein R 1 is hydrogen and R 3 is hydrogen.

32. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein m is 0.

33. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 7 is phenyl optionally substituted with 1, 2, 3, 4 or 5 substituents selected from halogen, CN, oxo, OR a , OC(O)R a , OC(O)OR a , OC(O)NR b R c , NR b R c , NR d C(O)R a , NR d C(O)OR a , NR d C(O)NR b R c , NR d C(O)C(O)NR b R c , NR d C(S)R a , NR d C(S)OR a , NR d C(S)NR b R c , NR d C(NR e )NR b R c , NR d S(O)R a , NR d SO 2 R a , NR d SO 2 NR b R c , C(O)R a , C(O)OR a , C(O)NR b R c , C(S)R a , C(S)OR a , C(S)NR b R c , C(NR e )NR b R c , SR a , S(O)R a , SO 2 R a , SO 2 NR b R c , C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C 6-10 aryl, C 7-11 aralkyl, and 5-10 membered heteroaryl, wherein each of the C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, 3-8 membered heterocycloalkyl, 3-8 membered heterocycloalkenyl, C 6-10 aryl, C 7-11 aralkyl and 5-10 membered heteroaryl groups is optionally substituted with 1, 2, 3, 4 or 5 R f substituents.

34. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 2 is phenyl optionally substituted with 1, 2, 3, 4 or 5 substituents selected from halogen, CN, (CH 2 ) n OR a , (CH 2 ) n OC(O)R a , (CH 2 ) n OC(O)OR a , (CH 2 ) n OC(O)NR b R c , (CH 2 ) n NR b R c , (CH 2 ) n NR d C(O)R a , (CH 2 ) n NR d C(O)OR a , (CH 2 ) n NR d C(O)NR b R c , (CH 2 ) n NR d C(O)C(O)NR b R c , (CH 2 ) n NR d C(S)R a , (CH 2 ) n NR d C(S)OR a , (CH 2 ) n NR d C(S)NR b R c , (CH 2 ) n NR d C(NR e )NR b R c , (CH 2 ) n NR d S(O)R a , (CH 2 ) n NR d SO 2 R a , (CH 2 ) n NR d SO 2 NR b R c , (CH 2 ) n C(O)R a , (CH 2 ) n C(O)OR a , (CH 2 ) n C(O)NR b R c , (CH 2 ) n C(S)R a , (CH 2 ) n C(S)OR a , (CH 2 ) n C(S)NR b R c , (CH 2 ) n C(NR e )NR b R c , (CH 2 ) n SR a , (CH 2 ) n S(O)R a , (CH 2 ) n SO 2 R a , (CH 2 ) n SO 2 NR b R c , C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, (CH 2 ) n C 3-8 cycloalkyl, (CH 2 ) n 3-8 membered heterocycloalkyl, (CH 2 ) n phenyl, (CH 2 ) n naphthyl and (CH 2 ) n 5-10 membered heteroaryl, wherein each of the C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, (CH 2 ) n C 3-8 cycloalkyl, (CH 2 ) n 3-8 membered heterocycloalkyl, (CH 2 ) n phenyl, (CH 2 ) n naphthyl and (CH 2 ) n 5-10 membered heteroaryl groups is optionally substituted with 1, 2, 3, 4 or 5 R f substituents.

35. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 4 is hydrogen.

36. The compound of claim 1 , wherein the compound is 4-fluoro-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzamide, or a pharmaceutically acceptable salt thereof.

37. The compound of claim 1 , wherein the compound is 4-fluoro-3-[6-({[(trans)-3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzamide, or a pharmaceutically acceptable salt thereof.

38. The compound of claim 1 , wherein the compound is 4-fluoro-3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzamide, or a pharmaceutically acceptable salt thereof.

39. The compound of claim 1 , wherein the compound is [6-(3-amino(1H-indazol-5-yl))pyridazin-3-yl]{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine, or a pharmaceutically acceptable salt thereof.

40. The compound of claim 1 , wherein the compound is [6-(3-amino(1H-indazol-5-yl))pyridazin-3-yl]{[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine, or a pharmaceutically acceptable salt thereof.

41. The compound of claim 1 , wherein the compound is [6-(3-amino(1H-indazol-5-yl))pyridazin-3-yl]{[(trans)-3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine, or a pharmaceutically acceptable salt thereof.

42. The compound of claim 1 , wherein the compound is N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)-2-hydroxyacetamide, or a pharmaceutically acceptable salt thereof.

43. The compound of claim 1 , wherein the compound is 2-amino-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)-2-methylpropanamide, or a pharmaceutically acceptable salt thereof.

44. The compound of claim 1 , wherein the compound is (2S)-2-amino-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)propanamide, or a pharmaceutically acceptable salt thereof.

45. The compound of claim 1 , wherein the compound is (2R)-2-amino-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)propanamide, or a pharmaceutically acceptable salt thereof.

46. The compound of claim 1 , wherein the compound is (2S)-2-amino-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)-3-hydroxy-3-methylbutanamide, or a pharmaceutically acceptable salt thereof.

47. The compound of claim 1 , wherein the compound is selected from:

3-(6-{[(4-fluorophenyl)cyclobutyl]amino}pyridazin-3-yl)benzamide;

(6-(1H-indazol-5-yl)pyridazin-3-yl)[(4-fluorophenyl)cyclobutyl]amine;

[6-(2-aminopyrimidin-5-yl)pyridazin-3-yl][(4-fluorophenyl)cyclobutyl]amine;

amino-N-[4-(6-{[(4-fluorophenyl)cyclobutyl]amino}pyridazin-3-yl)phenyl]amide;

3-(6-{[(2-fluorophenyl)cyclobutyl]amino}pyridazin-3-yl)benzamide;

3-(6-{[(3-fluorophenyl)cyclobutyl]amino}pyridazin-3-yl)benzamide;

3-{6-[(2-pyridylcyclobutyl)amino]pyridazin-3-yl}benzamide;

(phenylcyclobutyl)(6-phenylpyridazin-3-yl)amine;

3-{6-[(phenylcyclobutyl)amino]pyridazin-3-yl}benzamide;

3-(6-{[(3-fluoro-2-pyridyl)cyclobutyl]amino}pyridazin-3-yl)benzamide;

3-(6-{[(5-fluoro-2-pyridyl)cyclobutyl]amino}pyridazin-3-yl)benzamide;

4-fluoro-3-(6-{[(4-fluorophenyl)cyclobutyl]amino}pyridazin-3-yl)benzamide;

[(4-fluorophenyl)cyclobutyl][6-(6-methoxy(2-pyridyl))pyridazin-3-yl]amine;

(6-benzimidazol-5-ylpyridazin-3-yl)[(4-fluorophenyl)cyclobutyl]amine;

[(4-fluorophenyl)cyclobutyl](6-pyrazol-4-ylpyridazin-3-yl)amine;

3-{6-[(1,3-thiazol-2-ylcyclobutyl)amino]pyridazin-3-yl}benzamide;

4-fluoro-3-(6-{[(3-fluoro(2-pyridyl))cyclobutyl]amino}pyridazin-3-yl)benzamide;

3-(6-{[(4-methoxy-2-pyridyl)cyclobutyl]amino}pyridazin-3-yl)benzamide;

[6-(3-fluoro(4-pyridyl))pyridazin-3-yl][(4-fluorophenyl)cyclobutyl]amine;

[(4-fluorophenyl)cyclobutyl](6-(4-pyridyl)pyridazin-3-yl)amine;

4-(6-{[(4-fluorophenyl)cyclobutyl]amino}pyridazin-3-yl)pyridine-2-carbonitrile;

4-(6-{[(4-fluorophenyl)cyclobutyl]amino}pyridazin-3-yl)pyridine-2-carboxamide;

[4-(6-{[(4-fluorophenyl)cyclobutyl]amino}pyridazin-3-yl)phenyl](methylsulfonyl)amine;

[(4-fluorophenyl)cyclobutyl][6-(2-methoxy(3-pyridyl))pyridazin-3-yl]amine;

[(4-fluorophenyl)cyclobutyl]{6-[2-(2,2,2-trifluoroethoxy)(3-pyridyl)]pyridazin-3-yl}amine;

3-(6-{[(4-chlorophenyl)cyclobutyl]amino}pyridazin-3-yl)benzamide;

3-(6-{[(4-cyanophenyl)cyclobutyl]amino}pyridazin-3-yl)benzamide;

3-(6-{[(3-chloro(2-pyridyl))cyclobutyl]amino}pyridazin-3-yl)-4-fluorobenzamide;

[3-(6-{[(4-fluorophenyl)cyclobutyl]amino}pyridazin-3-yl)phenyl](methylsulfonyl)amine;

3-(6-{[(4-carbamoylphenyl)cyclobutyl]amino}pyridazin-3-yl)benzamide;

[(4-fluorophenyl)cyclobutyl][6-(2-methyl(4-pyridyl))pyridazin-3-yl]amine;

[(4-fluorophenyl)cyclobutyl][6-(2-methoxy(4-pyridyl))pyridazin-3-yl]amine;

3-(6-{[(6-methoxy-2-pyridyl)cyclobutyl]amino}pyridazin-3-yl)benzamide;

4-fluoro-3-(6-{[(6-methoxy(2-pyridyl))cyclobutyl]amino}pyridazin-3-yl)benzamide;

[3-(6-{[(6-methoxy(2-pyridyl))cyclobutyl]amino}pyridazin-3-yl)phenyl](methylsulfonyl)amine;

[3-(6-{[(3-fluoro(2-pyridyl))cyclobutyl]amino}pyridazin-3-yl)phenyl](methylsulfonyl)amine;

amino-N-[4-(6-{[(3-fluoro(2-pyridyl))cyclobutyl]amino}pyridazin-3-yl)phenyl]amide;

(6-(1H-indazol-6-yl)pyridazin-3-yl)[(3-fluoro(2-pyridyl))cyclobutyl]amine;

(6-benzimidazol-6-ylpyridazin-3-yl)[(3-fluoro(2-pyridyl))cyclobutyl]amine;

3-[6-({[6-(difluoromethoxy)-2-pyridyl]cyclobutyl}amino)pyridazin-3-yl]benzamide;

3-[6-({[6-(difluoromethoxy)(2-pyridyl)]cyclobutyl}amino)pyridazin-3-yl]-4-fluorobenzamide;

{3-[6-({[6-(difluoromethoxy)(2-pyridyl)]cyclobutyl}amino)pyridazin-3-yl]phenyl}(methylsulfonyl)amine;

4-fluoro-3-(6-{[(4-fluorophenyl)cyclobutyl]amino}pyridazin-3-yl)benzoic acid;

[4-fluoro-3-(6-{[(4-fluorophenyl)cyclobutyl]amino}pyridazin-3-yl)phenyl]-N-(2-hydroxy-2-methylpropyl)carboxamide;

3-(6-{[(3-bromo(2-pyridyl))cyclobutyl]amino}pyridazin-3-yl)-4-fluorobenzamide;

4-chloro-3-(6-{[(3-fluoro(2-pyridyl))cyclobutyl]amino}pyridazin-3-yl)benzamide;

[4-(6-{[(4-fluorophenyl)cyclobutyl]amino}pyridazin-3-yl)(2-pyridyl)]-N-methylcarboxamide;

(6-(1H-indazol-5-yl)pyridazin-3-yl)[(3-fluoro(2-pyridyl))cyclobutyl]amine;

[6-(6-fluoro(1H-indazol-5-yl))pyridazin-3-yl][(3-fluoro(2-pyridyl))cyclobutyl]amine;

amino-N-[4-fluoro-3-(6-{[(3-fluoro(2-pyridyl))cyclobutyl]amino}pyridazin-3-yl)phenyl]amide;

amino[4-fluoro-3-(6-{[(3-fluoro(2-pyridyl))cyclobutyl]amino}pyridazin-3-yl)phenyl]sulfonamide;

amino[3-fluoro-4-(6-{[(3-fluoro(2-pyridyl))cyclobutyl]amino}pyridazin-3-yl)phenyl]sulfonamide;

amino-N-[3-fluoro-4-(6-{[(3-fluoro(2-pyridyl))cyclobutyl]amino}pyridazin-3-yl)phenyl]amide;

3-(6-{[(4-cyano(2-pyridyl))cyclobutyl]amino}pyridazin-3-yl)-4-fluorobenzamide;

2-({[6-(3-carbamoyl-6-fluorophenyl)pyridazin-3-yl]amino}cyclobutyl)pyridine-4-carboxamide;

3-(6-{[(5-cyano(2-pyridyl))cyclobutyl]amino}pyridazin-3-yl)-4-fluorobenzamide;

3-(6-{[(6-cyano(2-pyridyl))cyclobutyl]amino}pyridazin-3-yl)-4-fluorobenzamide;

6-({[6-(3-carbamoyl-6-fluorophenyl)pyridazin-3-yl]amino}cyclobutyl)pyridine-2-carboxamide;

4-fluoro-3-(6-{[(3-hydroxy(2-pyridyl))cyclobutyl]amino}pyridazin-3-yl)benzamide;

4-fluoro-3-(6-{[(3-methoxy(2-pyridyl))cyclobutyl]amino}pyridazin-3-yl)benzamide;

3-[6-({[3-(difluoromethoxy)(2-pyridyl)]cyclobutyl}amino)pyridazin-3-yl]-4-fluorobenzamide;

3-[6-({[3-(difluoromethoxy)-2-pyridyl]cyclobutyl}amino)pyridazin-3-yl]benzamide;

{3-[6-({[3-(difluoromethoxy)(2-pyridyl)]cyclobutyl}amino)pyridazin-3-yl]phenyl}(methylsulfonyl)amine;

4-fluoro-3-(6-{[(5-methoxy(2-pyridyl))cyclobutyl]amino}pyridazin-3-yl)benzamide;

3-[6-({[5-(difluoromethoxy)(2-pyridyl)]cyclobutyl}amino)pyridazin-3-yl]-4-fluorobenzamide;

4-fluoro-3-(6-{[(5-hydroxy(2-pyridyl))cyclobutyl]amino}pyridazin-3-yl)benzamide;

4-fluoro-3-(6-{[(3-fluoro(2-pyridyl))cyclobutyl]amino}pyridazin-3-yl)benzenecarbonitrile;

[(3-fluoro(2-pyridyl))cyclobutyl](6-phenylpyridazin-3-yl)amine;

(6-cyclohexylpyridazin-3-yl)[(3-fluoro(2-pyridyl))cyclobutyl]amine;

(6-cyclohex-1-enylpyridazin-3-yl)[(3-fluoro(2-pyridyl))cyclobutyl]amine;

4-fluoro-3-(6-{[(3-fluoro(2-pyridyl))cyclopentyl]amino}pyridazin-3-yl)benzamide;

2-(6-{[(3-fluoro-2-pyridyl)cyclobutyl]amino}pyridazin-3-yl)-1,3-thiazole-5-carboxamide;

5-(6-{[(3-fluoro(2-pyridyl))cyclobutyl]amino}pyridazin-3-yl)-2-hydroxybenzamide;

[6-(3-amino(1H-indazol-5-yl))pyridazin-3-yl][(3-fluoro(2-pyridyl))cyclobutyl]amine;

2-(6-{[(4-fluorophenyl)cyclobutyl]amino}pyridazin-3-yl)-1,3-thiazole-5-carboxamide;

5-(6-{[(3-fluoro-2-pyridyl)cyclobutyl]amino}pyridazin-3-yl)thiophene-2-carboxamide;

5-(6-{[(4-fluorophenyl)cyclobutyl]amino}pyridazin-3-yl)thiophene-2-carboxamide; and

5-(6-{[(3-fluoro-2-pyridyl)cyclobutyl]amino}pyridazin-3-yl)thiophene-2-carboxylic acid;

or a pharmaceutically acceptable salt thereof.

48. The compound of claim 1 , wherein the compound is selected from:

3-[6-({[(4-fluorophenyl)cyclopropyl]methyl}amino)pyridazin-3-yl]benzamide;

5-[6-({[(4-fluorophenyl)cyclopropyl]methyl}amino)pyridazin-3-yl]pyridine-3-carboxamide

5-[6-({[(4-fluorophenyl)cyclopropyl]methyl}amino)pyridazin-3-yl]pyridine-3-carbonitrile;

3-[6-({[(2-chlorophenyl)cyclopropyl]methyl}amino)pyridazin-3-yl]benzamide;

5-[6-({[(4-fluorophenyl)cyclopropyl]methyl}amino)pyridazin-3-yl]-3-hydrobenzimidazol-2-one;

[6-(3-amino(1H-indazol-5-yl))pyridazin-3-yl]{[(4-fluorophenyl)cyclopropyl]methyl}amine;

[6-(3-amino(1H-indazol-5-yl))pyridazin-3-yl]{[(2-fluorophenyl)cyclopropyl]methyl}amine;

[6-(3-amino(1H-indazol-5-yl))pyridazin-3-yl]{[(2-fluorophenyl)cyclobutyl]methyl}amine;

[6-(3-amino(1H-indazol-5-yl))pyridazin-3-yl]{[(4-fluorophenyl)cyclobutyl]methyl}amine;

[6-(3-amino(1H-indazol-5-yl))pyridazin-3-yl]{[(2-fluorophenyl)cyclopentyl]methyl}amine;

[6-(3-amino(1H-indazol-5-yl))pyridazin-3-yl]{[(4-fluorophenyl)cyclohexyl]methyl}amine;

[6-(3-amino(1H-indazol-5-yl))pyridazin-3-yl][(phenylcyclopropyl)methyl]amine;

[6-(3-amino(1H-indazol-5-yl))pyridazin-3-yl][(phenylcyclobutyl)methyl]amine;

[6-(3-amino(1H-indazol-5-yl))pyridazin-3-yl][(2,2-dimethyl-1-phenylcyclopropyl)methyl]amine;

[6-(3-amino(1H-indazol-5-yl))pyridazin-3-yl]{[(4-fluorophenyl)cyclopentyl]methyl}amine;

[6-(3-amino(1H-indazol-5-yl))pyridazin-3-yl]{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

3-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]benzamide;

{[(4-fluorophenyl)cyclobutyl]methyl}[6-(2-methoxypyrimidin-5-yl)pyridazin-3-yl]amine;

[6-(3-amino(1H-indazol-5-yl))pyridazin-3-yl]{[(5-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

3-[6-({[(5-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]benzamide;

4-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]benzamide;

4-fluoro-3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzamide;

(6-(1H-indazol-5-yl)pyridazin-3-yl){[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

(6-(1H-indazol-6-yl)pyridazin-3-yl){[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

(6-(1H-indazol-6-yl)pyridazin-3-yl){[(6-methoxy(2-pyridyl))cyclobutyl]methyl}amine;

(6-(1H-indazol-5-yl)pyridazin-3-yl){[(6-methoxy(2-pyridyl))cyclobutyl]methyl}amine;

4-fluoro-3-[6-({[(6-methoxy(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzamide;

4-fluoro-3-(6-{[(2-pyridylcyclobutyl)methyl]amino}pyridazin-3-yl)benzamide;

(6-(1H-indazol-5-yl)pyridazin-3-yl)[(2-pyridylcyclobutyl)methyl]amine;

(6-(1H-indazol-6-yl)pyridazin-3-yl)[(2-pyridylcyclobutyl)methyl]amine;

2-fluoro-3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzamide;

3-fluoro-4-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzamide;

6-({[(6-(1H-indazol-5-yl)pyridazin-3-yl)amino]methyl}cyclobutyl)pyridin-2-ol;

6-({[(6-(1H-indazol-6-yl)pyridazin-3-yl)amino]methyl}cyclobutyl)pyridin-2-ol;

4-fluoro-3-[6-({[(6-hydroxy(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzamide;

2-({[(6-(1H-indazol-5-yl)pyridazin-3-yl)amino]methyl}cyclobutyl)pyridin-4-ol;

4-fluoro-3-[6-({[(4-methoxy(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzamide;

(6-(1H-indazol-5-yl)pyridazin-3-yl){[(4-methoxy(2-pyridyl))cyclobutyl]methyl}amine;

(6-(1H-indazol-6-yl)pyridazin-3-yl){[(4-methoxy(2-pyridyl))cyclobutyl]methyl}amine;

2-({[(6-(1H-indazol-6-yl)pyridazin-3-yl)amino]methyl}cyclobutyl)pyridin-4-ol;

4-fluoro-3-[6-({[(4-hydroxy(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzamide;

5-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-3-hydrobenzimidazol-2-one;

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}(6-pyrazol-4-ylpyridazin-3-yl)amine;

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}[6-(1-methylpyrazol-4-yl)pyridazin-3-yl]amine;

3-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]benzenesulfonamide;

{4-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}(methylsulfonyl)amine;

{3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}(methylsulfonyl)amine;

4-fluoro-3-[6-({[(3-methoxy(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzamide;

(6-(1H-indazol-5-yl)pyridazin-3-yl){[(3-methoxy(2-pyridyl))cyclobutyl]methyl}amine;

(6-(1H-indazol-6-yl)pyridazin-3-yl){[(3-methoxy(2-pyridyl))cyclobutyl]methyl}amine;

4-fluoro-3-[6-({[(5-methoxy(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzamide;

(6-(1H-indazol-5-yl)pyridazin-3-yl){[(5-methoxy(2-pyridyl))cyclobutyl]methyl}amine;

(6-(1H-indazol-6-yl)pyridazin-3-yl){[(5-methoxy(2-pyridyl))cyclobutyl]methyl}amine;

3-{[(6-(1H-indazol-6-yl)pyridazin-3-yl)amino]methyl}-3-(2-pyridyl)cyclobutan-1-ol;

3-[6-({[(4-fluorophenyl)cyclobutyl]methyl}amino)pyridazin-3-yl]benzamide;

3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-4-methylbenzamide;

6-({[(6-(1H-indazol-5-yl)pyridazin-3-yl)amino]methyl}cyclobutyl)pyridine-3-carbonitrile;

6-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-3,3-dimethylindolin-2-one;

3-[6-({[(4-cyano-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]benzamide;

2-[({[6-(3-carbamoylphenyl)pyridazin-3-yl]amino}methyl)cyclobutyl]pyridine-4-carboxamide;

3-[6-({[(4-cyano(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-4-fluorobenzamide;

2-[({[6-(3-carbamoyl-6-fluorophenyl)pyridazin-3-yl]amino}methyl)cyclobutyl]pyridine-4-carboxamide;

2-({[(6-(1H-indazol-5-yl)pyridazin-3-yl)amino]methyl}cyclobutyl)pyridine-4-carbonitrile;

2-({[(6-(1H-indazol-5-yl)pyridazin-3-yl)amino]methyl}cyclobutyl)pyridine-4-carboxamide;

3-[6-({[(6-cyano-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]benzamide;

6-[({[6-(3-carbamoylphenyl)pyridazin-3-yl]amino}methyl)cyclobutyl]pyridine-2-carboxamide;

6-({[(6-(1H-indazol-5-yl)pyridazin-3-yl)amino]methyl}cyclobutyl)pyridine-2-carbonitrile;

6-({[(6-(1H-indazol-5-yl)pyridazin-3-yl)amino]methyl}cyclobutyl)pyridine-2-carboxamide;

(6-(1H-indazol-6-yl)pyridazin-3-yl){[(4-fluorophenyl)cyclobutyl]methyl}amine;

(6-(1H-indazol-5-yl)pyridazin-3-yl){[(4-fluorophenyl)cyclobutyl]methyl}amine;

3-(6-{[(2-pyridylcyclobutyl)methyl]amino}pyridazin-3-yl)benzamide;

methyl 3-(3-fluoro(2-pyridyl))-3-{[(6-(1H-indazol-5-yl)pyridazin-3-yl)amino]methyl}azetidinecarboxylate;

methyl 3-({[6-(3-carbamoylphenyl)pyridazin-3-yl]amino}methyl)-3-(3-fluoro(2-pyridyl))azetidinecarboxylate;

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}{6-[3-(methylamino)(1H-indazol-5-yl)]pyridazin-3-yl}amine;

2-fluoro-5-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzoic acid;

{2-fluoro-5-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}-N-methylcarboxamide;

N-{5-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1H-indazol-3-yl}acetamide;

2-amino-N-{5-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1H-indazol-3-yl)}acetamide;

{5-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1H-indazol-3-yl)}(methylsulfonyl)amine;

3-amino-5-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-1H-indazolecarboxamide;

[6-(3-aminophenyl)pyridazin-3-yl]{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

[6-(4-aminophenyl)pyridazin-3-yl]{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

(6-{3-[(2-aminoethyl)amino](1H-indazol-5-yl)}pyridazin-3-yl){[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

amino{3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}carboxamidine;

amino{4-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}carboxamidine;

3-(6-{[(pyrazin-2-ylcyclobutyl)methyl]amino}pyridazin-3-yl)benzamide;

(6-(1H-indazol-6-yl)pyridazin-3-yl)[(pyrazin-2-ylcyclobutyl)methyl]amine;

(6-(1H-indazol-5-yl)pyridazin-3-yl)[(pyrazin-2-ylcyclobutyl)methyl]amine;

amino-N-{3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}amide;

5-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]benzene-1,3-dicarboxylic acid;

5-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]benzene-1,3-dicarboxamide;

3-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]benzenecarboxamidine;

3-[6-({[1-acetyl-3-(3-fluoro(2-pyridyl))azetid in-3-yl]methyl}amino)pyridazin-3-yl]benzamide;

1-acetyl-3-(3-fluoro(2-pyridyl))-3-{[(6-(1H-indazol-5-yl)pyridazin-3-yl)amino]methyl}azetidine;

(6-(1H-indazol-5-yl)pyridazin-3-yl){[3-(3-fluoro(2-pyridyl))azetid in-3-yl]methyl}amine;

3-[6-({[3-(3-fluoro-2-pyridyl)azetidin-3-yl]methyl}amino)pyridazin-3-yl]benzamide;

3-(3-fluoro(2-pyridyl))-3-{[(6-(1H-indazol-5-yl)pyridazin-3-yl)amino]methyl}-1-(methylsulfonyl)azetidine;

3-[6-({[3-(3-fluoro(2-pyridyl))-1-(methylsulfonyl)azetidin-3-yl]methyl}amino)pyridazin-3-yl]benzamide;

(6-(1H-indazol-5-yl)pyridazin-3-yl){[3-(3-fluoro(2-pyridyl))azetid in-3-yl]methyl}(methylsulfonyl)amine;

amino{5-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1H-indazol-3-yl)}carboxamidine;

3-[6-({[3-(4-fluorophenyl)oxetan-3-yl]methyl}amino)pyridazin-3-yl]benzamide;

{6-[3-(ethylamino)(1H-indazol-5-yl)]pyridazin-3-yl}{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

N-{4-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]imidazol-2-yl}acetamide;

[6-(2-aminoimidazol-4-yl)pyridazin-3-yl]{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}(6-{3-[(methylethyl)amino](1H-indazol-5-yl)}pyridazin-3-yl)amine;

{6-[3-(ethylamino)(1H-indazol-5-yl)]pyridazin-3-yl}[(2-pyridylcyclobutyl)methyl]amine;

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}{6-[2-(trifluoromethoxy)phenyl]pyridazin-3-yl}amine;

{2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}methan-1-ol;

[6-(5-amino(2-pyridyl))pyridazin-3-yl]{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

[6-(6-amino(3-pyridyl))pyridazin-3-yl]{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

[6-(4-amino-3-fluorophenyl)pyridazin-3-yl]{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

(6-benzotnazol-6-ylpyridazin-3-yl){[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

4-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]indolin-2-one;

(6-benzimidazol-5-ylpyridazin-3-yl){[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

N-{3-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}acetamide;

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}[6-(4-morpholin-4-ylphenyl)pyridazin-3-yl]amine,

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}[6-(2-methylpyrimidin-5-yl)pyridazin-3-yl]amine;

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}(6-pyrimidin-2-ylpyridazin-3-yl)amine;

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}(6-pyrazin-2-ylpyridazin-3-yl)amine;

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}(6-phenylpyridazin-3-yl)amine;

N-{4-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}acetamide;

[6-(2-aminopyrimidin-5-yl)pyridazin-3-yl]{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

N-{5-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]pyrimidin-2-yl}acetamide;

N-{5-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]pyrimidin-2-yl}methoxycarboxamide;

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}[6-(5-methoxy(2-pyridyl))pyridazin-3-yl]amine;

6-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]pyridin-3-ol;

{5-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]pyrimidin-2-yl}(methylsulfonyl)amine;

[6-(2,3-difluorophenyl)pyridazin-3-yl]{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}[6-(3-fluoro(2-pyridyl))pyridazin-3-yl]amine;

5-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]indolin-2-one;

5-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1H-2-hydroindazol-3-one;

N-{3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}(methylamino)carboxamide;

N-{4-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}(methylamino)carboxamide;

tert-butyl 4-{5-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]pyrimidin-2-yl}piperazinecarboxylate;

2-({5-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]pyrimidin-2-yl}amino)acetamide;

{6-[2-(aminomethyl)-5-fluorophenyl]pyridazin-3-yl}{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

{6-[2-(aminomethyl)phenyl]pyridazin-3-yl}{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

{6-[4-(aminomethyl)phenyl]pyridazin-3-yl}{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}[6-(2-piperazinylpyrimidin-5-yl)pyridazin-3-yl]amine;

[6-(3-chloro(2-pyridyl))pyridazin-3-yl]{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}[6-(2-methyl(3-pyridyl))pyridazin-3-yl]amine;

3-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]pyridine-2-carbonitrile;

3-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]pyridine-2-carboxamide;

methyl 3-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]pyridine-2-carboxylate;

2-{3-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-2-pyridyl}propan-2-ol;

amino-N-{4-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}amide;

2-amino-2-{3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}acetamide;

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}(6-pyridazin-4-ylpyridazin-3-yl)amine;

3-[6-({[3,3-difluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzamide;

(6-(1H-indazol-5-yl)pyridazin-3-yl){[3,3-difluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

5-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-(methylethyl)-1H-2-hydroindazol-3-one;

5-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-1-(methylethyl)-1H-2-hydroindazol-3-one;

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}(6-(2-pyridyl)pyridazin-3-yl)amine;

{3-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-2-pyridyl}methan-1-ol;

amino-N-{5-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](2-pyridyl)}amide;

1-amino-1-{4-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}-2-methylpropan-2-ol;

amino-N-{5-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]pyrimidin-2-yl}amide;

(6-(1H-indazol-6-yl)pyridazin-3-yl){[3,3-difluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

[6-(2-amino(3-pyridyl))pyridazin-3-yl]{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

[6-(6-amino-5-fluoro(3-pyridyl))pyridazin-3-yl]{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

6-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]indolin-2-one;

amino-N-{4-[6-({[3,3-difluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}amide;

ethyl 5-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]isoxazole-3-carboxylate;

5-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]isoxazole-3-carboxylic acid;

5-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]isoxazole-3-carboxamide;

amino-N-{5-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1H-indazol-3-yl)}amide;

4-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-1-methylimidazole-2-carboxamide;

4-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-methoxybenzamide;

4-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-hydroxybenzamide;

5-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-methoxybenzamide;

5-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-hydroxybenzamide;

4-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-methoxybenzoic acid;

5-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-methoxybenzoic acid;

5-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-oxazole-2-carboxamide;

4-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]imidazole-2-carboxamide;

3-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]isoxazole-5-carboxamide;

3-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]pyrazole-5-carboxamide;

3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-1-methylpyrazole-5-carboxamide;

5-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-1-methylpyrazole-3-carboxamide;

2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-oxazole-5-carboxamide;

2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazole-4-carboxamide;

5-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,2,4-oxadiazole-3-carboxamide;

2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-oxazole-4-carboxamide;

2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazole-5-carboxamide;

methyl 2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-oxazole-4-carboxylate;

methyl 2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazole-4-carboxylate;

methyl 2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-oxazole-5-carboxylate;

2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]imidazole-4-carboxamide;

methyl 2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]imidazole-4-carboxylate;

4-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazole-2-carboxamide;

5-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazole-2-carboxamide;

3-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,2,4-oxadiazole-5-carboxamide;

5-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-4H-1,2,4-triazole-3-carboxamide;

methyl 2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-1-methyl imidazole-4-carboxylate;

2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-1-methyl imidazole-4-carboxamide;

2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-1-methyl imidazole-5-carboxamide;

5-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]thiophene-2-carboxamide;

5-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3,4-thiadiazole-2-carboxamide;

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}(6-(1,3-thiazol-2-yl)pyridazin-3-yl)amine;

(6-(2H-1,2,3,4-tetraazol-5-yl)pyridazin-3-yl){[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

5-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3,4-oxadiazole-2-carboxamide;

2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-4-methyl-1,3-thiazole-5-carboxamide;

2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazole-5-carboxylic acid;

2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazole-5-carbonitrile;

5-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]thiophene-2-carboxylic acid;

2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-4-hydroxy-1,3-thiazole-5-carboxamide;

5-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-3-pyrazolino[3,4-d]1,3-thiazol-3-one;

{2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}methan-1-ol;

[6-(5-(2H-1,2,3,4-tetraazol-5-yl)(1,3-thiazol-2-yl))pyridazin-3-yl]{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

5-{2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}-1,3,4-oxadiazolin-2-one;

ethyl 3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-5-hydroxypyrazole-4-carboxylate;

3-{2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}-1,2,4-triazolin-5-one;

3-{2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}-1,2,4-oxadiazolin-5-one;

ethyl 2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-4-hydroxy-1,3-thiazole-5-carboxylate;

2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-4-methoxy-1,3-thiazole-5-carboxamide;

2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-4-methoxy-1,3-thiazole-5-carboxylic acid;

1-{2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}ethan-1-ol;

2,2,2-trifluoro-1-{2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}ethan-1-ol;

{2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}-N-(methylethyl)carboxamide;

ethyl 2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazole-4-carboxylate;

2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-3-pyrrolino[3,4-d]1,3-thiazol-6-one;

1-{2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}ethan-1-one;

2-{2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}propan-2-ol;

1,1,1-trifluoro-2-{2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}propan-2-ol;

{2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}-N-methylcarboxamide;

3-(6-{[(2-pyridylcyclobutyl)methyl]amino}pyridazin-3-yl)benzenecarbonitrile;

3-(6-{methyl [(2-pyridylcyclobutyl)methyl]amino}pyridazin-3-yl)benzamide;

6-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]pyrazine-2-carbonitrile;

6-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]pyrazine-2-carboxamide;

2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-4-hydroxy-1,3-thiazole-5-carbonitrile;

2-(6-{[(2-pyridylcyclobutyl)methyl]amino}pyridazin-3-yl)-1,3-thiazole-5-carboxamide;

2-(6-{[(2-pyridylcyclobutyl)methyl]amino}pyridazin-3-yl)-1,3-thiazole-5-carboxylic acid;

3-{5-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-2-thienyl}-1,2,4-triazolin-5-one;

amino{2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methane-1-thione;

2,2,2-trifluoro-1-{2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}ethane-1,1-diol;

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}{6-[5-(2,2,2-trifluoroethyl)(1,3-thiazol-2-yl)]pyridazin-3-yl}amine;

5-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]thiophene-2-carbonitrile;

2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]thiopheno[2,3-c]3-pyrrolin-6-one;

{6-[5-(1-amino-2,2,2-trifluoroethyl)(1,3-thiazol-2-yl)]pyridazin-3-yl}{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

[6-(2-aminopyrimidin-4-yl)pyridazin-3-yl]{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

2-{5-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,2,3,4-tetraazol-2-yl}acetamide;

{6-[2-(2-aminoethyl)(1,2,3,4-tetraazol-5-yl)]pyridazin-3-yl}{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

[6-(3-(2H-1,2,3,4-tetraazol-5-yl)phenyl)pyridazin-3-yl]{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

3-{3-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}-1,2,4-triazolin-5-one;

3-{4-fluoro-3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}-1,2,4-triazolin-5-one;

{6-[5-(aminomethyl)(1,3-thiazol-2-yl)]pyridazin-3-yl}{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

N-((2-(6-((1-(3-fluoropyridin-2-yl)cyclobutyl)methylamino)pyridazin-3-yl)thiazol-5-yl)methyl)-2-methylpropane-2-sulfinamide;

{6-[5-(aminoethyl)(1,3-thiazol-2-yl)]pyridazin-3-yl}{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

{6-[5-(3-aminooxetan-3-yl)(1,3-thiazol-2-yl)]pyridazin-3-yl}{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]pyrimidine-4-carboxamide;

{2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}-N-(2-hydroxyethyl)carboxamide;

ethyl 5-chloro-2-[5-chloro-6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazole-4-carboxylate;

N-{4-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]pyrimidin-2-yl}acetamide;

{4-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]pyrimidin-2-yl}(methylsulfonyl)amine;

(2E)-3-amino-3-{2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}-2-azaprop-2-enenitrile;

N-({2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}methyl)acetamide;

({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)(methylsulfonyl)amine;

N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)methoxycarboxamide;

2,2-difluoro-1-{2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}ethan-1-ol;

2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)morpholin-4-yl ketone;

N-(2-aminoethyl){2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}carboxamide;

N-(2,3-dihydroxypropyl){2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}carboxamide;

{2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}-N-pyrrolidin-3-ylcarboxamide;

2-{2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}acetamide;

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}[6-(5-pyrazol-4-yl(1,3-thiazol-2-yl))pyridazin-3-yl]amine;

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}[6-(5-pyrazol-3-yl(1,3-thiazol-2-yl))pyridazin-3-yl]amine;

4-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]pyrimidine-2-carboxamide;

6-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]pyrimidine-4-carboxamide;

N-(carbamoylmethyl){2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}carboxamide;

4-({2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}carbonyl)piperazine-2-carboxamide;

[6-(5-chloro(1,3-thiazolino[5,4-b]pyridin-2-yl))pyridazin-3-yl]{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}(6-(1,3-thiazolino[5,4-b]pyridin-2-yl)pyridazin-3-yl)amine;

[6-(5-amino(1,3-thiazolino[5,4-b]pyridin-2-yl))pyridazin-3-yl]{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

amino{4-fluoro-3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}sulfonamide;

2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)3-hydroxypyrrolidinyl ketone;

4-({2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}carbonyl)-1,4-thiazaperhydroine-1,1-dione;

N-(1,1-dioxothiolan-3-yl){2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}carboxamide;

{2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}-N-[2-(methylsulfonyl)ethyl]carboxamide;

2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)3-hydroxypiperidyl ketone;

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}(6-pyrazolo[5,4-d]1,3-thiazol-5-ylpyridazin-3-yl)amine;

2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)4-hydroxypiperidyl ketone;

4-({2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}carbonyl)piperazin-2-one;

{2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}-N-(oxolan-2-ylmethyl)carboxamide;

1-({2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}carbonyl)piperidine-3-carboxamide;

2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazolino[5,4-b]pyridine-5-carboxamide;

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}[6-(5-methoxy(1,3-thiazolino[5,4-b]pyridin-2-yl))pyridazin-3-yl]amine;

2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazolino[5,4-b]pyridin-5-ol;

N-((2R)-2,3-dihydroxypropyl){2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}carboxamide;

N-((2S)-2,3-dihydroxypropyl){2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}carboxamide;

N-(2-amino-3,3,3-trifluoropropyl){2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}carboxamide;

N-(3-amino-2,2-difluoropropyl){2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}carboxamide;

{2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}-N,N-dimethylcarboxamide;

N-(2,2-difluoro-3-hydroxypropyl){2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}carboxamide;

{2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}-N-(2-oxopyrrolidin-3-yl)carboxamide;

3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzamide;

4-fluoro-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzamide;

2-amino-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)acetamide;

((2S)pyrrolidin-2-yl)-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)carboxamide;

((2R)pyrrolidin-2-yl)-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)carboxamide;

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}(6-(3-pyrrolino[3,4-d]1,3-thiazol-2-yl)pyridazin-3-yl)amine;

2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-5-(methylsulfonyl)-3-pyrrolino[3,4-d]1,3-thiazole;

N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)-2-hydroxyacetamide;

2-[({2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}methyl)amino]acetamide;

((2S)-5-oxopyrrolidin-2-yl)-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)carboxamide;

N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)-2-hydroxy-2-methylpropanamide;

N-((3S)pyrrolidin-3-yl){2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}carboxamide;

N-((3R)pyrrolidin-3-yl){2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}carboxamide;

((3S)morpholin-3-yl)-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)carboxamide;

N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)pyrazol-5-ylcarboxamide;

N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)imidazol-2-ylcarboxamide;

N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)pyrazol-4-ylcarboxamide;

((4S)-2-oxoimidazolidin-4-yl)-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)carboxamide;

((3S)-6-oxo(3-piperidyl))-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)carboxamide;

2H-1,2,3-triazol-4-yl-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)carboxamide;

(2S)-2-amino-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)-3-hydroxypropanamide;

((2S)-4-acetylpiperazin-2-yl)-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)carboxamide;

[(2S)-4-(methylsulfonyl)piperazin-2-yl]-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)carboxamide;

((3S)morpholin-3-yl)-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)carboxamide;

1H-1,2,4-triazol-5-yl-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)carboxamide;

((2R)-6-oxo(2-piperidyl))-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)carboxamide;

N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)imidazol-5-ylcarboxamide;

2-amino-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)-2-methylpropanamide;

(2S)-2-amino-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)propanamide;

N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)(2-hydroxyimidazol-5-yl)carboxamide;

(2S)-2-amino-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)-3-hydroxy-3-methylbutanamide;

(2S)-2-amino-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)propanamide;

((3R)-1,1-dioxo(1,4-thiazaperhydroin-3-yl))-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)carboxamide;

((2S)-4,4-difluoropyrrolidin-2-yl)-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)carboxamide;

tert-butyl (2S)-4,4-difluoro-2-[N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)carbamoyl]pyrrolidinecarboxylate;

((2S)-4,4-difluoro-1-formylpyrrolidin-2-yl)-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)carboxamide;

((2R,4R)-4-fluoropyrrolidin-2-yl)-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)carboxamide;

N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)-2-methylpropanamide;

amino-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)amide;

((3S)-1,1-dioxo(1,4-thiazaperhydroin-3-yl))-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)carboxamide;

N-({2-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}methyl)acetamide;

4-fluoro-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzamide;

4-fluoro-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzenecarbonitrile;

3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-4-hydroxybenzamide;

4-fluoro-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzoic acid;

N-((2R)-2,3-dihydroxypropyl){4-fluoro-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}carboxamide;

N-((3R)pyrrolidin-3-yl){4-fluoro-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}carboxamide;

N-((3S)pyrrolidin-3-yl){4-fluoro-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}carboxamide;

[6-(3-(2H-1,2,3,4-tetraazol-5-yl)phenyl)pyridazin-3-yl]{[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazole-5-sulfonamide;

(aminocyclopropyl)-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)carboxamide;

(N-{1-[N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)carbamoyl]-isopropyl}carbamoyloxy)ethyl 2-methylpropanoate;

3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzoic acid;

3-(6-{[(3-fluoro-1-(2-pyridyl)cyclobutyl)methyl]amino}pyridazin-3-yl)benzoic acid;

3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzenecarbonitrile;

N-((2S)-2,3-dihydroxypropyl){4-fluoro-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}carboxamide;

methyl 4-fluoro-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzoate;

{4-fluoro-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}-N-methylcarboxamide;

{4-fluoro-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}-N-(methylethyl)carboxamide;

methyl 3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzoate;

methylethyl 4-fluoro-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzoate;

6-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]imidazo[2,1-b]1,3-thiazoline-3-carboxamide;

6-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]imidazo[2,1-b]1,3-thiazoline-3-carboxylic acid;

6-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]imidazo[2,1-b]1,3-thiazoline-3-carboxamide;

3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzenesulfonamide;

{5-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1H-indazol-3-yl)}(methylsulfonyl)amine;

{[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}{6-[3-(methylamino)(1H-indazol-5-yl)]pyridazin-3-yl}amine;

{6-[3-(ethylamino)(1H-indazol-5-yl)]pyridazin-3-yl}{[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

[6-(3-amino(1H-indazol-5-yl))pyridazin-3-yl]{[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

ethyl 2-fluoro-5-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzoate;

2-fluoro-5-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzoic acid;

2-{4-fluoro-3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}acetamide;

methyl 2-{4-fluoro-3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}acetate;

N-({4-fluoro-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}methyl)acetamide;

N-({3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}methyl)acetamide;

{2-fluoro-5-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}-N-methylcarboxamide;

N-ethyl{2-fluoro-5-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}carboxamide;

methyl 5-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-(methylamino)benzoate;

ethyl 5-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-(methylamino)benzoate;

{3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}methan-1-ol;

((2S)azetidin-2-yl)-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)carboxamide;

ethyl 2-{2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-4-yl}acetate;

2-{2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-4-yl}acetamide;

2-{2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}-2-methylpropanenitrile;

2-{2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}-2-methylpropanamide;

3-{2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}propanamide;

3-{2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}propanoic acid;

methyl 3-{2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}propanoate;

2-amino-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)-2-methyl-N-methylpropanamide;

2-{2-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}acetamide;

2-{2-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}acetic acid;

(3-aminooxetan-3-yl)-N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)carboxamide;

{3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}-N-methylcarboxamide;

{4-fluoro-3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}-N-methylcarboxamide;

N-({5-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-2-yl}methyl)acetamide;

N-({4-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-2-yl}methyl)acetamide;

2-{2-[6-({[1-(3-chloro(2-pyridyl))-3-fluorocyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}acetamide;

{3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}-N-methylcarboxamide;

2-{2-[6-({[(3-chloro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}acetamide;

2-{2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}acetic acid;

2-{2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}-N-methylacetamide;

2-{2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}-N,N-dimethylacetamide;

N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)-2-methyl-2-(methylamino)propanamide;

N-ethyl{4-fluoro-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}carboxamide;

N-(2-fluoroethyl){4-fluoro-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}carboxamide;

N-(2,2-difluoroethyl){4-fluoro-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}carboxamide;

{4-fluoro-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}-N-(2,2,2-trifluoroethyl)carboxamide;

{4-fluoro-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}-N,N-dimethylcarboxamide;

3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-4-hydroxybenzoic acid;

{3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-4-hydroxyphenyl}-N-methylcarboxamide;

3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-4-hydroxybenzamide;

5-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-methoxypyridine-3-carbonitrile;

5-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-methoxypyridine-3-carboxamide;

5-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-hydroxybenzoic acid;

{3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}-N-[2-hydroxy-1-(hydroxymethyl)ethyl]carboxamide;

{5-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-hydroxyphenyl}-N-methylcarboxamide;

5-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-hydroxybenzamide;

{3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-4-hydroxyphenyl}-N-methylcarboxamide;

{5-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](2-thienyl)}-N-methylcarboxamide;

2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-4,5,6-trihydrocyclopenta[1,2-d]1,3-thiazole-4-carboxamide;

2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-4,5,6-trihydrocyclopenta[1,2-d]1,3-thiazole-4-carboxylic acid;

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}(6-(4,5,6,7-tetrahydro-1,3-thiazolo[5,4-c]pyridin-2-yl)pyridazin-3-yl)amine;

N-{2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](4,5,6-trihydrocyclopenta [2,3-d]1,3-thiazol-4-yl)}methoxycarboxamide;

2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-4,5,6,7-tetrahydro-1,3-thiazolo[5,4-c]pyridine-5-carboxamide;

5-acetyl-2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-4,5,6,7-tetrahydro-1,3-thiazolo[5,4-c]pyridine;

2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1,3-thiazolo[5,4-c]pyridine;

{5-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-hydroxyphenyl}-N,N-dimethylcarboxamide;

4-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]isoindolin-1-one;

5-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]isoindolin-1-one;

6-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]isoindolin-1-one;

[6-(6-amino(4,5,6,7-tetrahydrobenzothiazol-2-yl))pyridazin-3-yl]{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

amino-N-{2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](4,5,6,7-tetrahydrobenzothiazol-6-yl)}amide;

N-{3-fluoro-4-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}(methylamino)carboxamide;

N-{4-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}-N-methyl(methylamino)carboxamide;

2-{2-[6-({[1-(3-chloro(2-pyridyl))-3-fluorocyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}-N-methylacetamide;

N-{4-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}(methylamino)carboxamide;

2-{2-[6-({[(3-chloro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}-N-methylacetamide;

N-cyclopropyl{4-fluoro-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}carboxamide;

{4-fluoro-5-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-hydroxyphenyl}-N-methylcarboxamide;

4-fluoro-5-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-hydroxybenzamide;

3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)-4-methylpyridazin-3-yl]benzenecarbonitrile;

3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)-4-methylpyridazin-3-yl]benzamide;

N-cyclobutyl{4-fluoro-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}carboxamide;

4-fluoro-3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)-4-methylpyridazin-3-yl]benzamide;

N-(3,3-difluorocyclobutyl){4-fluoro-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}carboxamide;

4-fluoro-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-hydroxybenzamide;

2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)-4-methylpyridazin-3-yl]-1,3-thiazole-5-carboxamide;

3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)-5-methylpyridazin-3-yl]benzamide;

N-cyclopropyl{3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}carboxamide;

[6-(2-aminopyrimidin-5-yl)pyridazin-3-yl]{[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

N-azetidin-3-yl{3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}carboxamide;

N-(1-acetylazetidin-3-yl){3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}carboxamide;

{3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}-N-[1-(methylsulfonyl)azetidin-3-yl]carboxamide;

{3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}-N-(2-hydroxy-2-methylpropyl)carboxamide;

{3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}-N-(1-methylazetidin-3-yl)carboxamide;

{3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}-N-oxetan-3-ylcarboxamide;

2-{2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)-4-methylpyridazin-3-yl]-1,3-thiazol-5-yl}acetic acid;

{2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)-4-methylpyridazin-3-yl]-1,3-thiazol-5-yl}methan-1-ol;

2-{2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)-4-methylpyridazin-3-yl](1,3-thiazol-5-yl)}-N-methylacetamide;

2-{2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)-4-methylpyridazin-3-yl]-1,3-thiazol-5-yl}acetamide;

{4-fluoro-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}-N-(1-methylazetidin-3-yl)carboxamide;

N-(1-acetylazetidin-3-yl){4-fluoro-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}carboxamide;

{3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}-N-(3-hydroxycyclobutyl)carboxamide;

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}{6-[5-(piperazinylmethyl)(1,3-thiazol-2-yl)]pyridazin-3-yl}amine;

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}{6-[5-(morpholin-4-ylmethyl)(1,3-thiazol-2-yl)]pyridazin-3-yl}amine;

4-({2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}methyl)-1,4-thiazaperhydroine-1,1-dione;

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}(6-{5-[(4-methylpiperazinyl)methyl](1,3-thiazol-2-yl)}pyridazin-3-yl)amine;

{[(3-fluoro(2-pyridyl))cyclobutyl]methyl}[6-(5-{[4-(2,2,2-trifluoroethyl)piperazinyl]methyl}(1,3-thiazol-2-yl))pyridazin-3-yl]amine;

1-acetyl-4-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)piperazine;

1-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)-4-(methylsulfonyl)piperazine;

[(2S)-1-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)piperazin-2-yl]methan-1-ol;

[(2R)-1-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)piperazin-2-yl]methan-1-ol;

N-(2H-3,4,5,6-tetrahydropyran-4-yl){3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}carboxamide;

{3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}-N-(3-hydroxy-3-methylcyclobutyl)carboxamide;

N-((3S)oxolan-3-yl){3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}carboxamide;

N-((3R)oxolan-3-yl){3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}carboxamide;

N-((3S,4S)-4-hydroxy-1,1-dioxothiolan-3-yl){3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}carboxamide;

N-(1,1-dioxothiolan-3-yl){3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}carboxamide;

3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-hydroxybenzamide;

3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-hydroxybenzamide;

5-amino-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzenecarbonitrile;

3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-5-(trifluoromethyl)benzamide;

5-chloro-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzamide;

3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-5-hydroxybenzamide;

5-amino-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]benzamide;

{3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-hydroxyphenyl}-N-methylcarboxamide;

3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-hydroxybenzenecarbonitrile;

3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-methoxybenzenecarbonitrile;

3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-hydroxybenzoic acid;

5-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-methoxybenzamide;

N-(1,1-dioxothietan-3-yl){3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}carboxamide;

4-fluoro-3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-hydroxybenzamide;

4-fluoro-5-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-hydroxybenzamide;

{3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]phenyl}-N-[(hydroxycyclopropyl)methyl]carboxamide;

{3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-5-methylphenyl}-N-methylcarboxamide;

3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-5-methylbenzamide;

3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-hydroxy-5-methylbenzamide;

3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-hydroxy-5-methylbenzenecarbonitrile;

5-bromo-3-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-hydroxybenzenecarbonitrile;

3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-methoxybenzamide;

{5-bromo-3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-hydroxyphenyl}-N-methylcarboxamide;

{3-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]-2-hydroxy-5-methylphenyl}-N-methylcarboxamide;

methyl 5-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]indole-2-carboxylate;

5-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]indole-2-carboxamide;

5-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]indole-2-carboxylic acid;

{5-[6-({[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl]indol-2-yl}-N-methylcarboxamide;

[6-(6-amino(3-pyridyl))pyridazin-3-yl]{[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

{[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}{6-[6-(methylamino)(3-pyridyl)]pyridazin-3-yl}amine;

{6-[6-(cyclopropylamino)(3-pyridyl)]pyridazin-3-yl}{[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

{6-[6-amino-5-(trifluoromethyl)(3-pyridyl)]pyridazin-3-yl}{[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

[N-({2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}methyl)carbamoyl]methyl acetate;

[N-({2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}methyl)carbamoyl]methyl (2S)-2-amino-3-methylbutanoate;

[N-({2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}methyl)carbamoyl]methyl (2S)-2-aminopropanoate;

{[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}[6-(6-methoxy-5-methyl(3-pyridyl))pyridazin-3-yl]amine;

[6-(6-amino-5-methyl(3-pyridyl))pyridazin-3-yl]{[3-fluoro-1-(3-fluoro(2-pyridyl))cyclobutyl]methyl}amine;

—N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)-2-hydroxypropanamide;

2-[({2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}methyl)amino]ethan-1-ol;

N-({2-[6-({[(3-fluoro(2-pyridyl))cyclobutyl]methyl}amino)pyridazin-3-yl](1,3-thiazol-5-yl)}methyl)-2-hydroxy-N-methylacetamide;

[N-({2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}methyl)carbamoyl]methyl (2S)-2-((2S)-2-aminopropanoylamino)propanoate; and

[N-({2-[6-({[(3-fluoro-2-pyridyl)cyclobutyl]methyl}amino)pyridazin-3-yl]-1,3-thiazol-5-yl}methyl)carbamoyl]methyl (2S)-2-((2S)-2-amino-3-methylbutanoylamino)-3-methylbutanoate;

or a pharmaceutically acceptable salt thereof.

49. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof.

50. The pharmaceutical composition of claim 49 , wherein the pharmaceutical composition is formulated for oral, sublingual, subcutaneous, parenteral, intravenous, intranasal, topical, transdermal, intraperitoneal, intramuscular, intrapulmonary, vaginal, rectal, or intraocular administration.

51. The pharmaceutical composition of claim 50 , wherein the pharmaceutical composition is formulated for oral administration.

Assignments (1)

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 30, 2013

From: ASHCRAFT, LUKE W.; BERGNES, GUSTAVE; COLLIBEE, SCOTT; CHUANG, CHIHYUAN; GARDINA, JEFF; MORGAN, BRADLEY P.; MUCI, ALEX R.; QIAN, XIANGPING; WARRINGTON, JEFFREY; YANG, ZHE; LU, PU-PING; ROMERO, ANTONIO

To: CYTOKINETICS, INC.

Reel/Frame 029725/0690 →

Continuity (3)

Provisional Application 61327538 · Apr 23, 2010

Provisional Application 61412302 · Nov 10, 2010

Related Publication 20130143862A1 · Jun 6, 2013