Methods of preparing nanoprobes and endoscope-like devices
The present invention is directed to methods of preparing nanoprobes, including multifunctional cellular endoscope-like devices, comprising nanotubes, nanorods, and/or nanowires.
1. A method of preparing a nanoprobe having a handle with an at least partially hollow distal chamber in fluid communication with a distal tip and at least one nanoelement protruding therefrom; said method comprising:
(a) placing a plurality of nanoelements suspended in a solvent into the distal tip;
(b) contacting the distal tip with a surface wettable by the solvent for a time and under conditions effective for a single nanoelement to contact said surface while remaining at least partially within the distal tip;
(c) withdrawing the distal tip of the nanoprobe away from the surface while maintaining contact of the single nanoelement with said surface until solvent in the distal tip is no longer in contact with said surface.
2. The method of claim 1 , further comprising holding the nanoprobe at the distance from the surface for a time and under conditions sufficient to allow at least a portion of the solvent remaining in the distal tip to evaporate.
3. The method of claim 1 , further comprising sealing the distal tip to form a leak-resistant seal between the nanoelement and the distal tip.
4. The method of claim 1 , wherein the at least one nanoelement is non-magnetic.
5. The method of claim 1 , wherein at least a portion of the nanoelements comprise carbon.
6. The method of claim 5 , wherein at least a portion of the nanoelements are carbon nanotubes.
7. The method of claim 5 , wherein the single nanoelement comprises carbon.
8. The method of claim 7 , wherein the single nanoelement is a carbon nanotube.
9. The method of claim 1 , wherein the solvent comprises water, ethanol, isopropanol, or a mixture thereof.
10. The method of claim 1 , wherein the solvent comprises water.
11. The method of claim 1 , wherein the surface comprises an oxide of aluminum, silicon, or both aluminum and silicon.
12. The method of claim 1 , wherein the surface comprises a sintered alumina.
13. The method of claim 1 , wherein the handle with an at least partially hollow distal chamber in fluid communication with a distal tip comprises glass.
14. The method of claim 3 , wherein the sealing comprises applying a sealant to the distal tip and curing said sealant.
15. The method of claim 14 , wherein the sealant is a thermal or photo-polymerizable sealant.
16. The method of claim 15 , wherein the sealant is an epoxy.
17. The method of claim 15 , wherein the sealant polymerizes by applying ultraviolet light.