Light-Emitting Devices for Wound Healing
Methods and devices related to wound healing using phototherapy are described. Some embodiments provide an organic light-emitting diode device, such as a light-emitting device for phototherapy, comprising Ring System 1, Ring System 2, Ring System 3, Ring System 4 or Ring System 5.
1 . A light-emitting device for use in phototherapy comprising:
a light-emitting layer comprising a luminescent compound that has a peak emission of about 620 nm to about 640 nm;
wherein the device is configured to provide an amount of light from the light-emitting layer effective to treat a wound of a mammal.
2 . The device of claim 1 , wherein the device is configured provide light to the wound at a power density of about 2 mW/cm 2 to about 20 mW/cm 2 .
3 . The device of claim 1 , wherein the device is configured provide light to the wound at a power density of about 7 mW/cm 2 to about 10 mW/cm 2 .
4 . The device of claim 1 , wherein the device further comprises a dosage component configured to deliver a light dose of about 0.1 J/cm 2 to about 10 J/cm 2 to a wound.
5 . The device of claim 4 , wherein the dosage component comprises a timer coupled to a positioning component.
6 . The device of claim 1 , wherein the device comprises a flexible substrate comprising an organic light-emitting diode coupled to the flexible substrate, wherein the light emitting diode comprises the light-emitting layer disposed between an anode and a cathode.
7 . The device of claim 1 , further comprising a capping layer disposed on a cathode.
8 . A phototherapy system comprising:
a device according to claim 1 ; and,
a wound dressing.
9 . The phototherapy system of claim 8 , further comprising a dosage component configured to deliver a light dose of about 0.05 J/cm 2 to about 15 J/cm 2 to a wound.
10 . The phototherapy system of claim 9 , wherein the dosage component is configured to deliver a light dose of about 0.2 J/cm 2 to about 5 J/cm 2 to the wound.
11 . The phototherapy system claim 8 , further comprising a hydrocolloid layer that is in direct contact with the device, wherein the phototherapy system is configured so that the hydrocolloid layer is disposed between the device and a wound when the phototherapy system is used to treat the wound.
12 . The phototherapy system of claim 11 , further comprising an adhesive layer, wherein the phototherapy system is configured so that the adhesive layer is disposed between, and in contact with the, wound and the hydrocolloid layer when the phototherapy system is used to treat the wound.
13 . The phototherapy system of claim 12 , wherein the hydrocolloid layer enhances the efficiency of light emission from the device.
14 . A method of treating a wound comprising: exposing at least a portion of a wound to light from a system of claim 8 .
15 . The method of claim 14 , wherein the wound is of a human being with diabetes.
16 . The method of claim 14 , wherein a light dose of 1 J/cm 2 to 5 J/cm 2 is delivered to the wound.
17 . The method of claim 14 , wherein a light dose of 5 J/cm 2 is delivered to the wound.
18 . The method of claim 14 , wherein the wound is treated from 2 days to 8 days after an injury.