Cycloalkyl-hydroxyl compounds and compositions for cholesterol management and related uses
The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, Syndrome X, thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
1. A method for treating or preventing dyslipidemia, dyslipoproteinemia, metabolic syndrome or Syndrome X, in a patient in need of such treatment or prevention, comprising administering to the patient a therapeutically or prophylactically effective amount of a compound of formula I:
or a pharmaceutically acceptable salt thereof, wherein:
(a) each occurrence of m is independently an integer ranging from 0 to 5;
(b) each occurrence of n is independently an integer ranging from 3 to 7;
(c) X is (CH 2 ) z or Ph; wherein z is an integer from 0 to 4;
(d) each occurrence of R 1 and R 2 is independently (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, phenyl, benzyl, or R 1 and R 2 and the carbon to which they are both attached are taken together to form a (C 3 -C 7 )cycloalkyl group;
(e) each occurrence of R 11 and R 12 and the carbon to which they are both attached are taken together to form a (C 3 -C 7 )cycloalkyl group;
(f) each occurrence of Y 1 and Y 2 is independently (C 1 -C 6 )alkyl, OH, COOH, COOR 3 , SO 3 H,
wherein:
(i) R 3 is (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, phenyl, or benzyl and is unsubstituted or substituted with one or more halo, OH, (C 1 -C 6 )alkoxy, or phenyl groups,
(ii) each occurrence of R 4 is independently H, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, or (C 2 -C 6 )alkynyl and is unsubstituted or substituted with one or two halo, OH, C 1 -C 6 alkoxy, or phenyl groups; and
(iii) each occurrence of R 5 is independently H, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, or (C2-C6)alkynyl.
2. The method of claim 1 , wherein each occurrence of Y 1 and Y 2 is independently OH, COOR 3 , or COOH.
3. The method of claim 1 , wherein m is 0.
4. The method of claim 1 , wherein m is 1.
5. The method of claim 1 , wherein n is 4.
6. The method of claim 1 , wherein n is 5.
7. The method of claim 1 , wherein X is (CH 2 ) z and z is 0.
8. The method of claim 1 , wherein each occurrence of R 1 and R 2 and the carbon to which they are both attached are taken together to form a (C 3 -C 7 )cycloalkyl group.
9. The method of claim 1 , wherein the compound of formula I is selected from the group consisting of
or a pharmaceutically acceptable salt thereof.
10. The method of claim 1 , wherein the compound of formula I is
or a pharmaceutically acceptable salt thereof.
11. The method of claim 1 wherein the compound of formula I is
12. The method of claim 1 wherein the compound of formula I is
or a pharmaceutically acceptable salt thereof.
13. The method of claim 1 wherein the compound of formula I is
or a pharmaceutically acceptable salt thereof.
14. The method of claim 1 wherein the compound of formula I is
or a pharmaceutically acceptable salt thereof.
15. The method of claim 1 , wherein the method comprises treating or preventing dyslipidemia and said dyslipidemia is hypertriglyceridemia.
16. The method of claim 10 , wherein the method comprises treating or preventing dyslipidemia and said dyslipidemia is hypertriglyceridemia.
17. The method of claim 1 , wherein the method comprises treating or preventing dyslipoproteinemia.
18. The method of claim 1 , wherein the method comprises treating or preventing metabolic syndrome or Syndrome X.
19. The method of claim 10 , wherein the method comprises treating or preventing dyslipoproteinemia.
20. The method of claim 10 , wherein the method comprises treating or preventing metabolic syndrome or Syndrome X.