IP Library Granted Patent US 9,042,201
Granted Patent B2
US 9,042,201 · App. 13/657,401 · Granted May 26, 2015

Method and system for direct communication

Inventors: William J. Tyler (Roanoke, VA); Isy Goldwasser (Los Gatos, CA); Robert Muratore (Huntington, NY); Sumon Pal (Boston, MA); Tomo Sato (Roanoke, VA); Daniel Z. Wetmore (San Francisco, CA)
Assignee: Thync, Inc.
H04B11/00A61B5/0476A61B5/165G06F3/015
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 9,042,201
App. No.
13/657,401
Granted
May 26, 2015
Kind
B2
Abstract

Information is communicated to an individual by directing an acoustic signal transcranially to a target region in the brain. The target region is stimulated to produce a cognitive effect, and the cognitive effect is modulated or encoded to carry the desired information.

Claims (153)

1. A method for communicating information to an individual, said method comprising:

translating the information into a series of ultrasound pulses for transmission to one or more target locations of a brain of the individual; and

directing the series of ultrasound pulses to the one or more target locations of the brain through a cranium of the individual to produce a cognitive effect which the individual perceives as the information.

2. The method of claim 1 , wherein the acoustic energy is directed at a target region in the brain to cause a selected cognitive effect.

3. The method of claim 2 , wherein the target region and cognitive effect are selected from the group consisting of:

Cognitive effect

Target region

Perception of touch

Somatosensory cortex

Auditory perception

Auditory cortex

Vestibular perception

Temporal-parietal junction, central sulcus,

intraparietal sulcus, and insular cortex

Visual perception

Primary and extrastriate visual cortex

Olfactory perception

Piriform cortex

Language comprehension

Wernicke's area

Language production

Broca's area

Long-term memory

Hippocampus and parahippocampal

formation (and connected portions of cortex,

e.g. entorhinal cortex and perirhinal cortex)

Modulation of pain

Rostral anterior cingulate cortex

processing

Emotion

Limbic system (e.g. amygdala)

Motor control and

Primary and supplementary motor cortex;

movements

thalamus; cerebellum; basal ganglia;

substantia nigra

Attention

Gamma rhythms

Relaxation

Alpha rhythms

Empathy, social

Brainstem nuclei, hypothalamus, amygdala,

interaction

anterior cingulated cortex, prefrontal cortex,

ventromedial prefrontal cortex, and other

brain regions involved in oxytocin and

arginine vasopressin function

Mirth and laughter

Inferior temporal gyrus, cingulated gyrus,

subthalamic nucleus

Fear

Amygdala, insular cortex, internal capsule,

nucleus accumbens, and anterior temporal

gyrus

Physiological arousal,

Various brainstem nuclei

sleep state

Modulation of risk taking

Dorsolateral prefrontal cortex.

4. The method of claim 3 , wherein modulating comprises at least one of:

(a) controlling the duration of the cognitive effect which is perceived by the individual;

(b) generating a series of off and on pulses of the cognitive effect which are perceived as a code by the individual

(c) directing the ultrasonic energy to different target regions to produce a perceptible pattern of different cognitive effects; and

(d) controlling the intensity of the cognitive effect in a perceptible pattern.

5. The method of claim 1 , wherein the acoustic energy has a frequency in a range between 100 kHz and 10 MHz.

6. The method of claim 1 wherein the acoustic energy has a spatial-peak, temporal-average intensity in brain tissue in a range from 0.0001 mW/cm 2 to 1 W/cm 2 .

7. The method of claim 6 , wherein the spatial-peak, temporal-average intensity in brain tissue is modulated to encode the information.

8. The method of claim 1 , wherein the heating of brain tissue at the target location is no more than 2 degrees Celsius for no more than 5 seconds.

9. The method of claim 1 , wherein the pulse length in a range between 0.5 microsecond and 5 seconds.

10. The method of claim 9 , wherein the pulse length is modulated.

11. The method of claim 1 , wherein the pulse repetition frequency is in a range between 50 Hz and 25 kHz.

12. A system for communicating information to an individual, said system comprising:

means for translating the information into a series of ultrasound pulses for transmission to one or more target locations of the individual's brain;

means for directing acoustic energy to the one or more target locations of the individual's brain through the individual's cranium to produce a cognitive effect; and

means for modulating the acoustic energy to encode the information transmitted to the one or more target locations with the series of ultrasound pulses, wherein the information is perceptible to the individual through variations in the cognitive effect.

13. The system of claim 12 , wherein the acoustic energy is directed at a target region in the brain to cause a selected cognitive effect.

14. The system as of claim 13 , wherein the target region and cognitive effect are selected from the group consisting of:

Cognitive effect

Target region

Perception of touch

Somatosensory cortex

Auditory perception

Auditory cortex

Vestibular perception

Temporal-parietal junction, central sulcus,

intraparietal sulcus, and insular cortex

Visual perception

Primary and extrastriate visual cortex

Olfactory perception

Piriform cortex

Language comprehension

Wernicke's area

Language production

Broca's area

Long-term memory

Hippocampus and parahippocampal

formation (and connected portions of cortex,

e.g. entorhinal cortex and perirhinal cortex)

Modulation of pain

Rostral anterior cingulate cortex

processing

Emotion

Limbic system (e.g. amygdala)

Motor control and

Primary and supplementary motor cortex;

movements

thalamus; cerebellum; basal ganglia;

substantia nigra

Attention

Gamma rhythms

Relaxation

Alpha rhythms

Empathy, social

Brainstem nuclei, hypothalamus, amygdala,

interaction

anterior cingulated cortex, prefrontal cortex,

ventromedial prefrontal cortex, and other

brain regions involved in oxytocin and

arginine vasopressin function

Mirth and laughter

Inferior temporal gyrus, cingulated gyrus,

subthalamic nucleus

Fear

Amygdala, insular cortex, internal capsule,

nucleus accumbens, and anterior temporal

gyrus

Physiological arousal,

Various brainstem nuclei

sleep state

Modulation of risk taking

Dorsolateral prefrontal cortex.

15. The system of claim 14 , wherein modulating comprises at least one of:

(a) controlling the duration of the cognitive effect which is perceived by the individual;

(b) generating a series of off and on pulses of the cognitive effect which are perceived as a code by the individual;

(c) directing the ultrasonic energy to different target regions to produce a perceptible pattern of different cognitive effects; and

(d) controlling the intensity of the cognitive effect in a perceptible pattern.

16. The system of claim 12 , wherein the acoustic energy has a frequency in a range between about 100 kHZ and about 10 MHz.

17. The system of claim 12 , wherein the acoustic energy has a spatial-peak, temporal-average intensity in brain tissue in a range from 0.0001 mW/cm2 to 1 W/cm2.

18. The system of claim 17 , wherein the spatial-peak, temporal-average intensity in brain tissue is modulated to encode the information.

19. The system of claim 12 , wherein the heating of brain tissue at the target location is no more than 2 degrees Celsius for no more than 5 seconds.

20. The system of claim 12 , wherein the pulse length is in a range between 0.5 microsecond and 5 seconds.

21. The system of claim 20 , wherein the pulse length is modulated during the bioTU protocol.

22. The system of claim 12 , wherein the pulse repetition frequency is in a range between 50 Hz and 25 kHz.

23. The method of claim 1 whereby the communication protocol specifies one or more of the acoustic frequency, duration, intensity, pulse repetition frequency, number of cycles, or duty cycle of the ultrasound wave.

24. A system for communicating information to an individual, comprising:

one or more ultrasound transducers;

a processor coupled to the one or more ultrasound transducers, the processor comprising instructions to,

translate the information into a series of ultrasound pulses to one or more target locations of a brain of the individual;

direct the series of ultrasound pulses to the one or more target locations of the brain through a cranium of the individual to produce a cognitive effect which the individual perceives as the information.

25. The system of claim 24 , whereby the one or more target locations of the brain are specified and targeted for brain stimulation as part of a communication protocol.

26. The method of claim 1 , wherein the information comprises symbolic information.

27. The system of claim 12 , wherein the information comprises symbolic information.

28. The system of claim 24 , wherein the information comprises symbolic information.

Assignments (5)
PATENT ASSIGNMENT AGREEMENT Recorded Jan 11, 2017
From: ABC-THY, LLC
To: HAIYIN EQUITY INVESTMENT FUND L.P.
Reel/Frame 041329/0759 →
PATENT ASSIGNMENT AGREEMENT Recorded Jan 11, 2017
From: HAIYIN EQUITY INVESTMENT FUND L.P.
To: CEREVAST MEDICAL, INC.
Reel/Frame 041330/0126 →
PATENT ASIGNMENT AGREEMENT Recorded Jan 6, 2017
From: THYNC, INC.
To: ABC-THY, LLC
Reel/Frame 041272/0916 →
CHANGE OF NAME Recorded Apr 3, 2015
From: NEUROTREK, INC.
To: THYNC, INC.
Reel/Frame 035383/0744 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 27, 2013
From: TYLER, WILLIAM J.; SATO, TOMO; WETMORE, DANIEL Z.; GOLDWASSER, ISY; MURATORE, ROBERT; PAL, SUMON
To: NEUROTREK, INC.
Reel/Frame 030702/0680 →
Continuity (2)
Provisional Application 61550334 · Oct 21, 2011
Related Publication 20140211593A1 · Jul 31, 2014