Antimicrobial Molecules For Treating Multi-Drug Resistant and Extensively Drug Resistant Strains Of Mycobacterium
The present invention provides methods of inhibiting the growth of Mycobacterium species or treating an animal having a Mycobacterium infection (including multi-drug resistance strains and extensively drug resistant strains) by administering a compound of the invention, a salt thereof, or a composition comprising the same.
1 . A method of inhibiting the growth of a Mycobacterium species comprising contacting the Mycobacterium species with an effective amount of a compound or salt thereof, wherein the compound or salt thereof is selected from:
a) a compound of Formula I:
or salt thereof, wherein R 1 is H or C 1-10 alkyl; R 2 is H or C 1-10 alkyl; and m is 1 or 2;
b) a compound of Formula II:
or salt thereof, wherein R 3 is H or C 1-10 alkyl; and R 4 is H or C 1-10 alkyl; and
c) a compound of Formula III:
or salt thereof, wherein R 5 is H or C 1-10 alkyl; and R 6 is H or C 1-10 alkyl.
2 . The method of claim 1 wherein the compound or salt thereof is a compound of Formula I or salt thereof.
3 . The method of claim 2 wherein the compound of Formula I or salt thereof is a compound of Formula Ia:
or salt thereof, wherein R 1 is H or C 1-8 alkyl; and R 2 is H or C 1-8 alkyl.
4 - 7 . (canceled)
8 . The method of claim 2 wherein the compound of Formula I or salt thereof is a compound of Formula Ib:
or salt thereof, wherein R 1 is H or C 1-10 alkyl; and R 2 is H or C 1-10 alkyl.
9 - 12 . (canceled)
13 . The method of claim 1 wherein the compound or salt thereof is a compound of Formula II or salt thereof.
14 - 16 . (canceled)
17 . The method of claim 1 wherein the compound or salt thereof is a compound of Formula III or salt thereof.
18 - 20 . (canceled)
21 . The method of claim 1 wherein the compound or salt thereof is a compound selected from:
or a salt thereof.
22 . The method of claim 1 wherein the Mycobacterium species is Mycobacterium Tuberculosis.
23 . The method of claim 22 wherein the Mycobacterium Tuberculosis is a multi-drug resistant strain.
24 . The method of claim 22 wherein the Mycobacterium Tuberculosis is an extensively drug resistant strain.
25 . A method of treating an animal having a Mycobacterium infection comprising administering to the animal a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof, wherein the compound or pharmaceutically acceptable salt thereof is selected from:
a) a compound of Formula I:
or a pharmaceutically acceptable salt thereof, wherein R 1 is H or C 1-10 alkyl; R 2 is H or C 1-10 alkyl; and m is 1 or 2;
b) a compound of Formula II:
or a pharmaceutically acceptable salt thereof, wherein R 3 is H or C 1-10 alkyl; and R 4 is H or C 1-10 alkyl; and
c) a compound of Formula III:
or a pharmaceutically acceptable salt thereof, wherein R 5 is H or C 1-10 alkyl; and R 6 is H or C 1-10 alkyl.
26 . The method of claim 25 wherein the compound or pharmaceutically acceptable salt thereof is a compound of Formula I or a pharmaceutically acceptable salt thereof.
27 . The method of claim 26 wherein the compound of Formula I or pharmaceutically acceptable salt thereof is a compound of Formula Ia:
or a pharmaceutically acceptable salt thereof, wherein R 1 is H or C 1-8 alkyl; R 2 is H or C 1-8 alkyl.
28 - 31 . (canceled)
32 . The method of claim 26 wherein the compound of Formula I or pharmaceutically acceptable salt thereof is a compound of Formula Ib:
or pharmaceutically acceptable salt thereof, wherein R 1 is H or C 1-10 alkyl; and R 2 is H or C 1-10 alkyl.
33 - 36 . (canceled)
37 . The method of claim 25 wherein the compound or pharmaceutically acceptable salt thereof is a compound of Formula II or pharmaceutically acceptable salt thereof.
38 - 40 . (canceled)
41 . The method of claim 25 wherein the compound or pharmaceutically acceptable salt thereof is a compound of Formula III or pharmaceutically acceptable salt thereof.
42 - 44 . (canceled)
45 . The method of claim 25 wherein the compound or pharmaceutically acceptable salt thereof is a compound selected from:
or a pharmaceutically acceptable salt thereof.
46 . The method of claim 25 wherein the Mycobacterium infection is Mycobacterium Tuberculosis.
47 . The method of claim 46 wherein the Mycobacterium Tuberculosis is a multi-drug resistant strain.
48 . The method of claim 46 wherein the Mycobacterium Tuberculosis is an extensively drug resistant strain.
49 . The method of claim 1 wherein the compound or salt thereof is present in a composition.
50 - 52 . (canceled)