Method of improving diastolic dysfunction
View Patent ↗A method of treating, preventing, reversing, or ameliorating diastolic dysfunction includes reducing S-glutathionylated myosin binding protein-C (MyBP-C) level by administering to a host in need thereof a therapeutically effective amount of tetrahydrobiopterin (BH 4 ).
1. A method of treating, reversing, or ameliorating diastolic dysfunction in a host with normal systolic function, comprising:
a) providing a host with normal systolic function with an ejection fraction of 50% or greater, and in need of treating, reversing, or ameliorating diastolic dysfunction; and
b) reducing S-glutathionylated myosin binding protein-C (MyBP-C) level by administering to the host a therapeutically effective amount of tetrahydrobiopterin (BH 4 ).
2. The method of claim 1 , wherein the step of administering comprises:
administering BH 4 in at least one form selected from the group consisting of a dietary supplement, a composition, a pharmaceutical composition, and a combination thereof.
3. The method of claim 1 , wherein the step of administering comprises:
administering BH 4 orally.
4. The method of claim 1 , wherein the host is a human.
5. The method of claim 1 , wherein the host is an animal.
6. A method of treating, preventing, reversing, or ameliorating diastolic dysfunction, comprising: modulating post-translational modification of myosin binding protein-C (MyBP-C) level by administering to a host in need thereof a therapeutically effective amount of tetrahydrobiopterin (BH4).
7. The method of claim 6 , wherein the step of administering comprises: administering BH4 in at least one form selected from the group consisting of a dietary supplement, a composition, a pharmaceutical composition, and a combination thereof.
8. The method of claim 6 , wherein the step of administering comprises: administering BH4 orally.
9. The method of claim 6 , wherein the host is a human.
10. The method of claim 6 , wherein the host is an animal.