Calcium phosphate nanowhisker particles, method of making and using the same
Calcium phosphate nanowhisker particles, methods of making and method of using are described.
1. A process for forming a calcium phosphate nanowhisker particle, comprising:
i) exposing a mixture of a soluble calcium, a soluble phosphate, and urea to microwave energy for a predetermined period of time and at a predetermined energy level sufficient to cause an exothermic reaction; and thereafter,
ii) cooling the mixture of step i) so that calcium phosphate nanowhiskers having a length:diameter aspect ratio of greater than about 1:1 are precipitated in a molten salt bath, wherein
the mixture comprises an aqueous solution of Ca(NO 3 ) 2 and an aqueous solution of KH 2 PO 4 at a ratio of about 1:0.38, by weight.
2. The process of claim 1 , wherein the mixture further includes at least one additive comprised at least of NaCl; and, wherein the additive and soluble calcium are present at a ratio of about 3.5:1, by weight.
3. The process of claim 1 , wherein the average aspect ratio of the particle is greater than about: 5:1; 10:1; 25:1 and/or 50:1.
4. The process of claim 1 , wherein the mixture comprises NaNO 3 , Ca(NO 3 ) 2 , KH 2 PO 4 , HNO 3 , and optionally one or more additives.
5. The process of claim 1 , wherein the microwave energy is supplied at a frequency in a range of about 2.4 to about 2.5 GHz, and at a power in a range of about 550 W to about 650 W.
6. The process of claim 1 , wherein the microwave energy is supplied at about 2.45 GHz and at power of about 600 W.
7. The process of claim 1 , wherein the calcium phosphate nanowhisker particles formed comprise one or more of: hydroxyapatite particles, beta-tricalcium phosphate particles, and mixtures thereof.
8. The process of claim 1 , wherein the mixture further includes at least one fluorescent material.
9. The process of claim 1 , wherein the nanowhisker particle comprises a lanthanide rare earth doped Ca—P.