pH-sensitive polymer-drug conjugates for targeted delivery of therapeutics
Polymeric delivery systems for boronic acid-containing therapeutics, related compounds and methods of use, for a pH-sensitive chemoselective approach to delivery of such a therapeutic.
1. A compound comprising a poly(alkylene oxide) component; and a component of repeating lysine monomeric units coupled thereto, each said lysine monomeric unit coupled to a catecholic component, each said catecholic component pendant to a said lysine monomeric unit and conjugated with a bortezomib component, said conjugation via a dihydroxyphenyl moiety of said catecholic component and a boronic acid moiety of said bortezomib component, or a salt of said compound.
2. The compound of claim 1 wherein each said poly(alkylene oxide) component comprises poly(ethylene oxide).
3. The compound of claim 1 wherein said poly(alkylene oxide) component comprises about 30-about 250 repeating monomeric ethylene oxide units.
4. The compound of claim 3 comprising up to about 8 catecholic components.
5. The compound of claim 1 comprising a cancer cell-targeting ligand, said compound in a pharmaceutical composition.