METHOD OF TREATING BRAIN CANCER
A therapeutic method for treating brain cancer is disclosed comprising administering to a patient in need of treatment a ruthenium complex salt.
1 . A method of treating or delaying the onset of brain cancer comprising administering to a patient in need of treatment a pharmaceutically acceptable salt of trans-[tetrachlorobis(1H-indazole)ruthenate(III)].
2 . The method of claim 1 , wherein the brain cancer is a refractory brain cancer.
3 . The method of claim 2 , wherein said brain cancer is glioma.
4 . The method of claim 2 , wherein said brain cancer is astrocytoma.
5 . The method according to claim 2 , wherein said pharmaceutically acceptable salt is an alkali metal salt of trans-[tetrachlorobis(1H-indazole)ruthenate(III)]
6 . The method according to claim 2 , wherein said pharmaceutically acceptable salt is sodium trans-[tetrachlorobis(1H-indazole)ruthenate(III)].
7 . The method of claim 2 , wherein said brain cancer is refractory to a treatment comprising a nitrosourea or temozolomide.
8 . The method of claim 7 , wherein said brain cancer was previously treated with BCNU.
9 . The method of claim 7 , wherein said brain cancer was previously treated with temozolomide.