HYALURONIC ACID-COLLAGEN MATRICES FOR DERMAL FILLING AND VOLUMIZING APPLICATIONS
Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.
1 . A soft tissue aesthetic product comprising:
a filler comprising a hydrogel having a form suitable for injecting into mammalian tissue; and
a label comprising instructions to inject the filler into the tissue;
wherein the hydrogel comprises water, and a crosslinked macromolecular matrix comprising:
a hyaluronic acid component; and
a collagen component;
wherein the hyaluronic acid component is crosslinked to the collagen component by a crosslinking component; and
wherein the crosslinking component comprises a plurality of crosslink units, wherein at least a portion of the crosslink units comprise an ester bond or an amide bond.
2 . The product of claim 1 , wherein the collagen component comprises collagen type I or collagen type III.
3 . The product of claim 1 , wherein crosslinked macromolecular matrix has a weight ratio of the hyaluronic acid component to the collagen component of about 1 to about 3.
4 . The product of claim 1 , wherein the hydrogel is in the form of a dermal filler.
5 . The product of claim 1 , wherein the hydrogel is in the form of a lip filler.
6 . A method of improving an aesthetic quality of soft tissue of a human being comprising:
injecting a hydrogel composition into a soft tissue of the human being to thereby improve the aesthetic quality of the soft tissue;
wherein the hydrogel composition comprises water, and a crosslinked macromolecular matrix comprising:
a hyaluronic acid component; and
a collagen component;
wherein the hyaluronic acid component is crosslinked to the collagen component by a crosslinking component; and
wherein the crosslinking component comprises a plurality of crosslink units, wherein at least a portion of the crosslink units comprise an ester bond or an amide bond.
7 . The method of claim 6 , wherein the collagen component comprises collagen type I or collagen type III.
8 . The method of claim 6 , wherein the hydrogel is in the form of a dermal filler.
9 . The method of claim 6 , wherein the hydrogel is in the form of a lip filler.
10 . A dermal filler comprising:
a hydrogel having a form suitable for injecting into mammalian tissue;
wherein the hydrogel comprises water, and a crosslinked macromolecular matrix comprising:
a hyaluronic acid component; and
a collagen component;
wherein the hyaluronic acid component is crosslinked to the collagen component by a crosslinking component; and
wherein the crosslinking component comprises a plurality of crosslink units, wherein at least a portion of the crosslink units comprise an ester bond or an amide bond.
11 . The dermal filler of claim 10 , wherein the collagen component comprises collagen type I or collagen type III.
12 . The dermal filler of claim 10 , wherein crosslinked macromolecular matrix has a weight ratio of the hyaluronic acid component to the collagen component of about 1 to about 3.
13 . The dermal filler of claim 10 wherein the crosslinked macromolecular matrix has a weight ratio of the hyaluronic acid component to the collagen component of about 1 to about 7.