TSPO ligands for cancer imaging and treatment
Embodiments of the present invention relates to compounds of the following formula: as well as compositions, methods of imaging and methods of treating subjects comprising the use of the compound, wherein the variables are defined herein.
1. A compound of the following formula:
or a pharmaceutically acceptable salt thereof.
2. A compound of the following formula:
or a pharmaceutically acceptable salt thereof.
3. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
4. A pharmaceutical composition comprising a compound of claim 2 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
5. A method of imaging a molecular event in a sample, comprising:
(a) administering a probe with an affinity for a target, the probe being selected from a compound of the following formula:
or a pharmaceutically acceptable salt thereof; and
(b) detecting a signal from said probe.
6. The method of claim 5 , wherein the sample is at least one of cells, tissue, cellular tissue, serum, cell extract, bodily fluids.
7. The method of claim 5 , wherein the administering step is in vivo or in vitro.
8. The method of claim 5 , wherein the detecting step is with PET imaging.
9. The method of claim 5 , wherein the molecular event is cell proliferation.
10. The method of claim 5 , further comprising the step of analyzing said signal to diagnose a disease state.
11. The method of claim 10 , further comprising the steps of administering a second probe, detecting a second signal, and comparing a first signal with the second signal to determine the progress of a disease state.
12. The method of claim 11 , wherein a treatment step for said disease state occurs between administering steps.
13. The compound of claim 1 , wherein the fluorine atom is 18 F.
14. The compound of claim 2 , wherein the fluorine atom is 18 F.
15. The compound of claim 3 , wherein the fluorine atom is 18 F.
16. The compound of claim 4 , wherein the fluorine atom is 18 F.
17. The method of claim 5 , wherein the fluorine atom is 18 F.