Neurotrophic peptides
View Patent ↗The present invention relates to a neurotrophic peptide having an amino acid sequence of VGDGGLFEKKL (SEQ ID NO: 1) and alternatively comprising an adamantyl group at the C-and/or N-terminal end. The neurotrophic peptide can rescue cognition, correct impairments in neural cell proliferation and synaptic plasticity, and thus address the cognitive defects associated with Alzheimer's disease.
1. A method of treating a subject having Alzheimer's disease comprising the step of administering a therapeutic amount of a neurotrophic peptide consisting of the amino acid sequence selected from the group consisting of VGDGGLFEKKL (SEQ ID NO: 1), GDGGLFEK (SEQ ID NO: 5), GLFEKKLW (SEQ ID NO: 6), VGDG (SEQ ID NO: 7), GDGG (SEQ ID NO: 8), DGGL (SEQ ID NO: 9), and GGLF (SEQ ID NO: 10).
2. The method of claim 1 , wherein said neurotrophic peptide is administered peripherally.
3. The method of claim 1 , wherein said neurotrophic peptide is administered subcutaneously.
4. The method of claim 1 , wherein said neurotrophic peptide is administered orally.
5. The method of claim 1 , wherein said neurotrophic peptide is administered intraperitoneally.
6. A method of treating a subject having Alzheimer's disease comprising the step of administering a therapeutic amount of a neurotrophic peptide consisting of the amino acid sequence DGGL (SEQ ID NO: 9) bound to an adamantane building block.
7. The method of claim 6 , wherein said adamantane building block is bound to a C-terminus of said neurotrophic peptide.
8. The method of claim 6 , wherein another adamantane building block is bound to an N-terminus of said neurotrophic peptide.
9. The method of claim 6 , wherein said adamantane building block comprises 3-aminoadamantane-1-carboxylic acid.
10. The method of claim 6 , wherein said neurotrophic peptide bound to said adamantane building block consists of the sequence Ac-DGGL A G-NH 2 (SEQ ID NO: 12).
11. The method of claim 6 , wherein said neurotrophic peptide bound to said adamantane building block consists of the sequence Ad-CO-DGGL A G-NH 2 (SEQ ID NO: 13).