Ingestible implement for weight control
An orally administrable implement for expanding in a stomach of an animal, including a mammal, to fill a space in the stomach, is provided for weight control. The implement includes: a fluid-permeable expandable container having a first dimension and a second dimension; and a plurality of clusters comprising a swellable material contained within the container and capable of swelling when contacted with a fluid; whereby when the implement is ingested, the fluid in the stomach enters the container causing the clusters therein to swell and the container to expand from the first dimension to the second dimension.
1. An orally administrable implement for expanding in a stomach of an animal, including a mammal, to fill a space in the stomach, comprising:
(a) a fluid-permeable expandable container having a first dimension and being expandable to a second dimension; and
(b) a plurality of clusters comprising a swellable material contained within the container and capable of swelling when contacted with a fluid;
whereby when the implement is ingested, the fluid in the stomach enters the container causing the clusters therein to swell and the container to expand from the first dimension to the second dimension;
wherein the container is made from an absorbable woven, knitted, braided or monofilament mesh material.
2. The orally administrable implement as claimed in claim 1 , wherein the container, while in the first dimension, is configured for retention in an ingestible capsule.
3. The orally administrable implement as claimed in claim 1 , wherein the container is configured to be sufficiently large in the second dimension so as to be retained in the stomach after ingestion.
4. The orally administrable implement as claimed in claim 1 , wherein the container is biodegradable over time.
5. The orally administrable implement as claimed in claim 4 , whereby when the container biodegrades the clusters are released into the stomach.
6. The orally administrable implement as claimed in claim 1 , wherein the clusters are configured to not exceed about 1.0 cm in diameter when swollen.
7. The orally administrable implement as claimed in claim 6 , wherein the clusters are configured to not exceed about 0.6 cm in diameter when swollen.
8. The orally administrable implement as claimed in claim 1 , wherein the container is made from a fluid-permeable stretchable material.
9. The orally administrable implement as claimed in claim 1 , wherein the container is made from a permeable absorbable mesh having radial fibers woven therethrough.
10. The orally administrable implement as claimed in claim 1 , further comprising a magnet retained in the container.
11. The orally administrable implement as claimed in claim 1 , further comprising at least one active agent, which can be releasably associated with either the container, the clusters of swellable material, or both.
12. The orally administrable implement as claimed in claim 11 , the at least one active agent is selected from the group consisting of enzymatic agents, medicinal agents, chemical agents, or combinations thereof.
13. The orally administrable implement as claimed in claim 1 , further comprising a radio-frequency identification (RFID) tag.
14. The orally administrable implement as claimed in claim 1 , further comprising a radio-frequency transmitter.
15. The orally administrable implement as claimed in claim 1 , further comprising a plurality of clusters comprising a substance-absorbing material contained within the container and capable of absorbing the targeted substance present in the stomach.
16. The orally administrable implement as claimed in claim 15 , wherein the substance-absorbing material is a lipid-absorbing material.
17. The orally administrable implement as claimed in claim 16 , wherein the lipid-absorbing material is lipid-absorbing chitosan fiber, oxidized cellulose fiber, or a combination of both.
18. The orally administrable implement as claimed in claim 1 , wherein the container is made from fiber comprising a substance-absorbing material.
19. The orally administrable implement as claimed in claim 18 , wherein the substance-absorbing material is a lipid-absorbing material.
20. The orally administrable implement as claimed in claim 19 , wherein the lipid-absorbing material is lipid-absorbing chitosan fiber, oxidized cellulose fiber, or a combination of both.
21. The orally administrable implement as claimed in claim 1 , wherein the implement is self-administrable in the case of humans or administrable autonomously.
22. An orally administrable implement for expanding in a stomach of an animal, including a mammal, to fill a space in the stomach, comprising:
(a) a fluid-permeable expandable container having a first dimension and a second dimension; and
(b) a plurality of clusters comprising a swellable material contained within the container and capable of swelling when contacted with a fluid;
whereby when the implement is ingested, the fluid in the stomach enters the container causing the clusters therein to swell and the container to expand from the first dimension to the second dimension;
wherein the container comprises a plurality of smaller sections, whereby each section is connected to one another by absorbable fiber to form the container.
23. The orally administrable implement as claimed in claim 22 wherein the container is made from an absorbable woven, knitted, braided or monofilament mesh material.
24. An orally administrable implement for expanding in a stomach of an animal, including a mammal, to fill a space in the stomach, comprising:
(a) a fluid-permeable expandable container having a first dimension and a second dimension; and
(b) a plurality of clusters comprising a swellable material contained within the container and capable of swelling when contacted with a fluid;
whereby when the implement is ingested, the fluid in the stomach enters the container causing the clusters therein to swell and the container to expand from the first dimension to the second dimension;
wherein the swellable material of the clusters is selected from the group consisting of a swelling bentonite, microcrystalline hydrogels, polyolefins and various mixtures thereof.