PERFLUOROCARBON GEL FORMULATIONS
A perfluorocarbon gel composition is disclosed with numerous uses including topical medical and cosmetic uses.
1 . A perfluorocarbon gel composition comprising 10-90 wt % perfluorocarbon and 8-70 wt % water relative to the total weight of the gel, wherein the perfluorocarbon is perfluoro(tert-butylcyclohexane).
2 . (canceled)
3 . The perfluorocarbon gel composition of claim 1 , wherein the composition further comprises 1-5 wt % surfactants.
4 . The perfluorocarbon gel composition of claim 3 , wherein the surfactants include polyoxyethylene-polyoxypropylene block copolymers.
5 . The perfluorocarbon gel composition of claim 4 , wherein the polyoxyethylene-polyoxypropylene block copolymers include Poloxamer 105 and/or Poloxamer 188.
6 . The perfluorocarbon gel composition of claim 1 , wherein the composition further comprises 0.01-10 wt % Vitamin E.
7 . The perfluorocarbon gel composition of claim 6 , wherein the composition comprises 0.03 wt % Vitamin E.
8 . The perfluorocarbon gel composition of claim 1 , wherein the composition further comprises 0.02-3.20 wt % preservatives.
9 . The perfluorocarbon gel composition of claim 8 , wherein the preservatives include poly(diallyldimethylammonium chloride), poly(acrylamide-co-diallyldimethylammonium chloride) and/or ethylene diamine tetraacetic acid.
10 . (canceled)
11 . The perfluorocarbon gel composition of claim 3 , wherein the composition comprises 30-50 wt % perfluorocarbon, 48-70 wt % water, and 2 wt % surfactants.
12 . (canceled)
13 . (canceled)
14 . The perfluorocarbon gel composition of claim 8 , wherein the preservatives include 0-0.40 wt % poly(diallyldimethylammonium chloride), 0.01-0.80 wt % poly(acrylamide-co-diallyldimethylammonium chloride) and 0.01-2.00 wt % ethylene diamine tetraacetic acid.
15 . The perfluorocarbon gel composition of claim 14 , wherein the composition comprises 84-88 wt % perfluoro(tert-butylcyclohexane), 9-11 wt % water, 2-3 wt % Poloxamer 105, 0.01-1 wt % Poloxamer 188, 0-0.40 wt % poly(diallyldimethylammonium chloride), 0.01-0.80 wt % poly(acrylamide-co-diallyldimethylammonium chloride) and 0.01-2.00 wt % ethylene diamine tetraacetic acid.
16 . The perfluorocarbon gel composition of claim 15 , wherein the composition comprises 85.98 wt % perfluoro(tert-butylcyclohexane), 10.28 wt % water, 2.45 wt % Poloxamer 105, 0.31 wt % Poloxamer 188, 0.74 wt % poly(acrylamide-co-diallyldimethylammonium chloride) and 0.25 wt % ethylene diamine tetraacetic acid.
17 . The perfluorocarbon gel composition of claim 15 , wherein the composition comprises 86.73 wt % perfluoro(tert-butylcyclohexane), 10.37 wt % water, 2.47 wt % Poloxamer 105, 0.31 wt % Poloxamer 188, 0.10 wt % poly(acrylamide-co-diallyldimethylammonium chloride) and 0.03 wt % ethylene diamine tetraacetic acid.
18 . The perfluorocarbon gel composition of claim 15 , wherein the composition comprises 85.98 wt % perfluoro(tert-butylcyclohexane), 10.28 wt % water, 2.45 wt % Poloxamer 105, 0.31 wt % Poloxamer 188, 0.25 wt % poly(diallyldimethylammonium chloride), 0.50 wt % poly(acrylamide-co-diallyldimethylammonium chloride) and 0.25 wt % ethylene diamine tetraacetic acid.
19 . The perfluorocarbon gel composition of claim 15 , wherein the composition comprises 86.73 wt % perfluoro(tert-butylcyclohexane), 10.37 wt % water, 2.47 wt % Poloxamer 105, 0.31 wt % Poloxamer 188, 0.03 wt % poly(diallyldimethylammonium chloride), 0.07 wt % poly(acrylamide-co-diallyldimethylammonium chloride) and 0.03 wt % ethylene diamine tetraacetic acid.
20 . (canceled)
21 . (canceled)
22 . The perfluorocarbon gel composition of claim 1 , characterized by that it continuously delivers oxygen to a tissue at a rate of 0.2 cc/hour-20.0 cc/hour for up to 24 hours.
23 . The perfluorocarbon gel composition of claim 22 , wherein the composition continuously delivers oxygen to the tissue at a rate of 2.0 cc/hour for 24 hours.
24 . The perfluorocarbon gel composition of claim 1 , further comprising urea hydrogen peroxide.
25 . A method of continuously delivering oxygen to a tissue at a rate of 0.2 cc/hour-20.0 cc/hour for up to 24 hours by contacting the tissue with the perfluorocarbon gel composition of claim 1 .
26 . A method of treating a wound, a burn injury, acne or rosacea in a subject suffering therefrom comprising topically administering to the skin of the subject the perfluorocarbon gel composition of claim 1 effective to treat the subject's wound, burn injury, acne or rosacea.
27 . A method of increasing the firmness of the skin or reducing the appearance of fine lines, wrinkles or scars in a subject comprising topically administering to the skin of the subject the perfluorocarbon gel composition of claim 1 effective to increase the firmness of the subject's skin or reduce the appearance of fine lines, wrinkles or scars on the subject's skin.
28 . A process of manufacturing a perfluorocarbon gel composition comprising the steps:
i) mixing aqueous phase components in a vessel;
ii) homogenizing the mixture;
iii) adding perfluorocarbon to the mixture over time during high speed homogenization; and
iv) obtaining the gel.
29 - 36 . (canceled)