Compositions and methods for stimulating immune response against
View Patent ↗This invention provides a method for stimulating in an individual an immune response against M. catarrhalis . The method comprises administering to an individual a composition comprising M. catarrhalis OppA protein in an amount effective to stimulate an immune response against M. catarrhalis in the individual.
1. A method of stimulating in an individual an immune response against Moraxella catarrhalis comprising administering to the individual a composition comprising isolated Moraxella catarrhalis OppA (Oligopeptide permease protein A) protein, wherein the isolated Moraxella catarrhalis OppA protein comprises the amino acid sequence of SEQ ID NO: 1, and wherein administering the composition results in a stimulated immune response against Moraxella catarrhalis in the individual.
2. The method of claim 1 , wherein the composition further comprises an adjuvant.
3. The method of claim 2 , wherein the adjuvant is a mucosal adjuvant.
4. The method of claim 1 , wherein the composition further comprises a pharmaceutically acceptable carrier.
5. The method of claim 1 , wherein the composition is administered to the individual by a route selected from subcutaneous, intramuscular, intravenous, intradermal, intranasal, oral and inhalation administrations.
6. The method of claim 1 , wherein the stimulated immune response in the individual comprises generation of antibodies against Moraxella catarrhalis.
7. The method of claim 6 , wherein the generation of antibodies comprises generation of IgG and/or IgA antibodies against Moraxella catarrhalis.
8. The method of claim 1 , wherein the stimulated immune response is associated with an enhanced rate of Moraxella catarrhalis bacterial clearance from the lungs of an individual to whom the composition is administered.
9. The method of claim 1 , wherein the composition is administered to the individual as several doses over a period of time.
10. The method of claim 1 , wherein the stimulated immune response is prophylactic against Moraxella catarrhalis infection in the individual.
11. The method of claim 1 , further comprising administering an antibiotic agent to the individual.
12. An immunogenic composition comprising isolated Moraxella catarrhalis OppA protein, wherein the isolated Moraxella catarrhalis OppA protein comprises the amino acid sequence of SEQ ID NO:1, wherein administration of the immunogenic composition results in immune response against Moraxella catarrhalis in an individual.
13. The composition of claim 12 , further comprising an adjuvant.
14. The composition of claim 13 , wherein the adjuvant is a mucosal adjuvant.