MEDICAL FLUID, A METHOD OF TREATMENT AND USE OF THE FLUID
A medical fluid for a harvested organ, tissue or parts thereof, for evaluation and/or preservation. The fluid includes cocaine or a stimulating analogue thereof; nor-adrenalin; and/or adrenaline. In addition, the fluid includes an oncotic agent, such as dextran; hormones, such as thyroxin; triiodotyronine; cortisone, insulin; and electrolytes and optionally nutrients in substantially physiological concentrations in a physiologically acceptable medium. In addition, the medical fluid further includes albumin in a concentration not exceeding 5.0%, and an oxygen carrier, such as erythrocytes. Further components may be dopamine; hydrocortisone; methylprednisolone; and a vasopressor agent, such as desmopressin. The cocaine; adrenalin; and noradrenaline are present in concentrations of each about 0.010 μM to 0.100 μM, for example in a ratio of 1:1:1.
1 . A medical fluid for a harvested organ, tissue or parts thereof, for evaluation and/or preservation, comprising:
cocaine or a stimulating analogue thereof; adrenalin and/or noradrenalin; an oncotic agent; hormones; and
electrolytes and optionally nutrients in substantially physiological concentrations in a physiologically acceptable medium.
2 . The fluid according to claim 1 , in which noradrenaline is present in a concentration of about 0.010 μM to 0.100 μM.
3 . The fluid according to claim 1 , in which adrenaline is present in a concentration of about 0.010 μM to 0.100 μM.
4 . The fluid according to claim 1 , in which cocaine or a stimulating analogue thereof is present in a concentration of about 0.010 μM to 0.100 μM.
5 . The fluid according to claim 1 , wherein said oncotic agent is albumin or dextran or a combination thereof.
6 . The fluid according to claim 1 , wherein said hormones are any one of thyroxin; triiodotyronine; or cortisone or a combination thereof.
7 . The fluid according to claim 1 , further comprising an oxygen carrier, such as erythrocytes.
8 . The fluid according to claim 1 , further comprising at least one of glucose; insulin; dopamine; hydrocortisone; methylprednisolone; and a vasopressor agent, such as desmopressin.
9 . The fluid according to claim 1 , wherein cocaine or a stimulating analogue thereof; adrenalin; and noradrenaline are present in concentrations of each about 0.010 μM to 0.100 μM.
10 . The fluid according to claim 1 , wherein cocaine or a stimulating analogue thereof; adrenalin; and noradrenaline are present in concentration ratios of 1:1:1.
11 . A method for treatment of a harvested organ for evaluation and/or preservation, comprising:
circulating a first fluid in the vascular system of the organ, and optionally partly or completely immersing said organ in a second fluid;
said first fluid comprising cocaine or a stimulating analogue thereof; adrenalin and/or noradrenalin; an oncotic agent; hormones; and
electrolytes and optionally nutrients in substantially physiological concentrations in a physiologically acceptable medium.
12 . The method according to claim 11 , in which noradrenaline is present in a concentration of about 0.010 μM to 0.100 μM.
13 . The method according to claim 11 , in which adrenaline is present in a concentration of about 0.010 μM to 0.100 μM.
14 . The method according to claim 11 , in which cocaine or a stimulating analogue thereof is present in a concentration of about 0.010 μM to 0.100 μM.
15 . The method according to claim 11 , in which said first fluid further comprises:
at least one of glucose; albumin; insulin; dopamine; hydrocortisone; methylprednisolone; a vasopressor agent; and an oxygen carrier.
16 . The method according to claim 11 , in which said second fluid further comprises:
at least one of glucose; albumin; insulin; dopamine; hydrocortisone; methylprednisolone; and a vasopressor agent, such as desmopressin; and an oxygen carrier, such as erythrocytes.
17 . The method according to claim 11 , wherein said first fluid is the same as said second fluid.
18 . Use of a fluid for a harvested organ, tissue or part thereof for evaluation and/or preservation, wherein the fluid comprises:
cocine or a stimulating analogue thereof; adrenalin; and/or nor-adrenalin;
an oncotic agent;
hormones; triiodotyronine; cortisone;
electrolytes and optionally nutrients in substantially physiological concentrations in a physiologically acceptable medium.
19 . The use according to claim 18 , wherein the fluid further comprises at least one of:
glucose; albumin; insulin; dopamine; hydrocortisone; methylprednisolone; a vasopressor agent; and an oxygen carrier.