IP Library › Patent Application 13700091
Patent Application
App. No. 13/700,091

CROSSLINKER ENHANCED REPAIR OF KNEE MENISCUS

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Quick Facts
Patent No.
US None
App. No.
13/700,091
Abstract

A method of treating a tear in a knee meniscus of a patient. The method includes exposing the torn knee meniscus to a protein crosslinker during surgery to repair the tear. Also provided is a fixation device for the surgical repair of tears of the meniscus of the knee, where the device contains one or more protein crosslinking reagents.

Claims (34)

1 . A method of treating a tear in a knee meniscus of a patient, comprising contacting a torn knee meniscus with a delivery device comprising a protein crosslinking agent during surgery to repair the tear, wherein the crosslinking agent increases the number of covalent crosslink bonds in native tissue in the knee meniscus.

2 . The method of claim 1 , wherein the delivery device comprises a patch or fixation device comprising the crosslinking agent.

3 . The method of claim 2 , wherein the fixation device is an arrow, dart, tack or suture.

4 . The method of claim 2 , wherein the patch or fixation device is biodegradable.

5 . The method of claim 2 , wherein the patch or fixation device further comprises a basic salt.

6 . The method of claim 5 , wherein the basic salt is calcium carbonate, calcium hydroxyapatite, sodium bicarbonate, 2-Amino-2-hydroxymethyl-propane-1,3-diol (Tris) or 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES).

7 . The method of claim 2 , wherein the patch is non-biodegradable.

8 . The method of claim 2 , wherein the patch is porous and the crosslinking agent is embedded within the pores.

9 . The method of claim 2 , wherein the crosslinking agent is adhered to one side of the patch as part of a semi-solid formulation.

10 . The method of claim 2 , wherein the patch or fixation device is coated with one or more layers of crosslinking agent-containing biodegradable polymer.

11 . The method of claim 10 , wherein each layer comprises a basic salt.

12 . The method of claim 11 , wherein the salt is calcium carbonate, calcium hydroxyapatite, sodium bicarbonate, 2-Amino-2-hydroxymethyl-propane-1,3-diol (Tris) or 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES).

13 . The method of claim 10 , wherein the patch or fixation device is coated with multiple layers of crosslinking agent-containing biodegradable polymer, and the crosslinking agent varies from layer to layer.

14 . The method of claim 2 , wherein the patch is affixed to the meniscus with a bio-compatible adhesive.

15 . The method of claim 14 , wherein the adhesive is poly(glycerol-co-sebacate acrylate), an oleic methyl ester or an alkyl ester cyanoacrylate.

16 . The method of claim 2 , wherein the patch is affixed to the meniscus by an associated fixation device.

17 . The method of claim 16 , wherein the associated fixation device is an arrow, dart, tack or suture.

18 . The method of claim 16 , wherein the associated fixation device comprises a crosslinking agent.

19 . A delivery device for contacting the knee meniscus of a patient, the device comprising a patch or fixation device comprising a protein crosslinking agent.

20 . The delivery device of claim 19 , wherein the fixation device is an arrow, dart, tack or suture.

21 . The delivery device of claim 19 , wherein the patch or fixation device is biodegradable.

22 . The delivery device of claim 19 , wherein the patch or fixation device further comprises a basic salt.

23 . The delivery device of claim 22 , wherein the basic salt is calcium carbonate, calcium hydroxyapatite, sodium bicarbonate, 2-Amino-2-hydroxymethyl-propane-1,3-diol (Tris) or 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES).

24 . The delivery device of claim 19 , wherein the patch is porous and the crosslinking agent is embedded within the pores.

25 . The delivery device of claim 19 , wherein the crosslinking agent is adhered to one side of the patch as part of a semi-solid formulation

26 . The delivery device of claim 19 , wherein the patch or fixation device is coated with one or more layers of crosslinking agent-containing biodegradable polymer.

27 . The delivery device of claim 26 , wherein each layer comprises a basic salt.

28 . The delivery device of claim 27 , wherein the salt is calcium carbonate, calcium hydroxyapatite, sodium bicarbonate, 2-Amino-2-hydroxymethyl-propane-1,3-diol (Tris) or 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES).

29 . The delivery device of claim 26 , wherein the patch or fixation device is coated with multiple layers of crosslinking agent-containing biodegradable polymer, and the crosslinking agent varies from layer to layer.

30 . The delivery device of claim 19 , wherein the patch is affixed to the meniscus with a bio-compatible adhesive.

31 . The delivery device of claim 30 , wherein the adhesive is poly(glycerol-co-sebacate acrylate), an oleic methyl ester or an alkyl ester cyanoacrylate.

32 . The delivery device of claim 19 , wherein the patch is affixed to the meniscus by an associated fixation device.

33 . The delivery device of claim 32 , wherein the associated fixation device is an arrow, dart, tack or suture.

34 . The delivery device of claim 33 , wherein the associated fixation device comprises a crosslinking agent.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 13, 2012
From: HEDMAN, THOMAS P.; SLUSAREWICZ, PAUL
To: ORTHOPEUTICS, L.P.
Reel/Frame 029466/0830 →