IP Library › Granted Patent US 8,765,784

Granted Patent B2

US 8,765,784 · App. 13/701,039 · Granted Jul 1, 2014

Positive allosteric modulators of MGLUR2

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Quick Facts

Patent No.: US 8,765,784
App. No.: 13/701,039
Granted: Jul 1, 2014
Kind: B2

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Abstract

The present invention is directed to 5-substituted 1,3-dihydro-2H-imidazo[4,5-b]pyridine-2-one derivatives which are positive allosteric modulators of the mGluR2 receptor, useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 receptor is involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved, such as schizophrenia.

Claims (604)

1. A compound according to Formula I

wherein:

Y is H, C 1-6 alkyl or C 2-6 alkenyl, said C 1-6 alkyl and C 2-6 alkenyl optionally substituted with 1 to 3 groups selected from: halo and C 1-4 alkoxy;

R 1 is selected from the group consisting of:

(1) C 2-8 alkyl,

(2) C 2-8 alkenyl,

(3) C 2-8 alkynyl,

(4) C 3-6 cycloalkyl-(CH 2 ) p —, wherein p is 1, 2, 3 or 4,

(5) benzyl,

(6) biphenyl, and

(7) 1-phenyl-1H-pyrazol-4-yl,

wherein groups (1) to (7) above are optionally substituted with 1 to 3 R 2 groups;

each R 2 is independently selected from the group consisting of: halo, OH, C 1-4 alkyl, C 1-4 alkoxy, CF 3 , —OCF 3 and —CN;

ring A is selected from aryl, heteroaryl and heterocycle, wherein said heterocycle is fused to an aryl group or a heteroaryl group, and wherein said aryl, heteroaryl and heterocycle are optionally substituted with one or more R 3 groups up to the maximum number of substitutable positions;

each R 3 is independently selected from the group consisting of: halo, —CN, —NO 2 , X, —C(R 4 ) 2 —N(R)—X, —C(R 4 ) 2 —N(R)C(O)—X, —C(R 4 ) 2 —N(R)S(O) k —X, —C(R 4 ) 2 —N(R)C(O)—O—X, —C(O)—X, —C(O)—O—X, —C(O)—N(R)—X, —S(O) k —X, —S(O) k N(R)—X, —N(R)—X, —O—X, —N(R)C(O)—X, —N(R)S(O) k —X, —N(R)C(O)—O—X, —N(R)C(O)N(R)—X and —N(R)SO 2 N(R)—X;

each X is independently selected from the group consisting of: H, C 1-8 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl, aryl, heteroaryl, heterocycle, C 3-6 cycloalkyl-C(R 4 ) 2 —, aryl-C(R 4 ) 2 —, heteroaryl-C(R 4 ) 2 — and heterocycle-C(R 4 ) 2 —, wherein each member of the group excluding hydrogen is optionally substituted from one up to the maximum number of substitutable positions with one or more substituents independently selected from the group consisting of: CN, halo, R 5 , —O—R 5 , —N(R)—R 5 , —N(R)C(O)—R 5 , —N(R)S(O) 2 —R 5 , —N(R)—C(O)—O—R 5 , —C(O)—N(R)—R 5 , —C(O)—O—R 5 , —C(O)—R 5 , —C(O)—C(R 4 ) 2 —R 5 , —C(O)—C(R 4 ) 2 —S(O) 2 —R 5 , —C(R 4 ) 2 —N(R)—R 5 , —SO 2 —N(R)—R 5 , —Si(CH 3 ) 2 (R 5 ), —C(R 4 ) 2 —R 5 and —SO 2 —R 5 ;

each k is independently 0, 1 or 2;

each R is independently selected from the group consisting of: H and C 1-4 alkyl;

each R 4 is independently selected from the group consisting of: H, OH and C 1-4 alkyl;

each R 5 is independently selected from the group consisting of: H, C 1-4 -alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, phenyl, heterocycle and heteroaryl, wherein each member of the group excluding hydrogen is optionally substituted with 1 to 3 substituents independently selected from: halogen, cyano, hydroxy and methyl;

aryl at each occurrence is independently selected from the group consisting of: phenyl, naphthyl, anthryl and phenanthryl;

heteroaryl at each occurrence independently means a 5-membered monocyclic aromatic selected from the group consisting of isoxazolyl, isothiazolyl, pyrazolyl, oxazolyl, oxadiazolyl, thiadiazolyl, thiazolyl, imidazolyl, triazolyl, tetrazolyl, furanyl, triazinyl and thienyl, a 6-membered monocyclic aromatic or 9- or 10-membered bicyclic aromatic, wherein at least one atom in the aromatic is selected from N(R), O and S, the sulfur optionally oxidized to sulfone or sulfoxide, and the remaining atoms are selected from C, N(R), O and S, the sulfur optionally oxidized to sulfone or sulfoxide;

heterocycle at each occurrence independently means a 4- to 7-membered monocyclic non-aromatic ring, an 8- to 11-membered bi-cyclic non-aromatic ring or a 12- to 20-membered tri-cyclic, non-aromatic ring, each optionally substituted with 1 to 2 oxo groups, wherein at least one atom is selected from N(R), O and S, the sulfur optionally oxidized to sulfone or sulfoxide, and the remaining atoms are selected from C, N(R), O and S, the sulfur optionally oxidized to sulfone or sulfoxide;

or a pharmaceutically acceptable salt thereof.

2. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein Y is methyl.

3. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein R 1 is selected from the group consisting of: cyclopropylmethyl, 2,2-difluorocyclopropylmethyl, 2,2-difluoro-1-methylcyclopropylmethyl, 1-(trifluoromethyl)cyclopropylmethyl, 4,4,4-trifluoro-2,2-dimethylbutyl, cyclobutylmethyl, 2,2-dimethylpropyl, prop-2-enyl, biphenyl and benzyl, optionally substituted with methoxy or —OCF 3 .

4. The compound according to claim 1 of Formula Ia

or a pharmaceutically acceptable salt thereof.

5. The compound according to claim 4 or a pharmaceutically acceptable salt thereof, wherein R 3 is selected from the group consisting of: halo, —CN, —N(O) 2 , amino, —N(C 1-4 alkyl) 2 , —C(O)—O—C 1-4 alkyl, —C(O)—C 1-4 alkyl, —S(O) 2 —C 1-4 alkyl, C 3-6 cycloalkyl, —C(C 1-4 alkyl) 2 -NHC(O)—O—C 1-4 alkyl and C 1-8 alkyl optionally substituted with 1 to 4 substituents independently selected from hydroxy and halo.

6. The compound according to claim 1 of Formula Ib

or a pharmaceutically acceptable salt thereof.

7. The compound according to claim 6 or a pharmaceutically acceptable salt thereof, wherein R 3 is selected from the group consisting of: halo, —CN, —N(O) 2 , amino, —N(C 1-4 alkyl) 2 , —C(O)—O—C 1-4 alkyl, —C(O)—C 1-4 alkyl, —S(O) 2 —C 1-4 alkyl, C 3-6 cycloalkyl and C 1-8 alkyl optionally substituted with 1 to 4 substituents independently selected from hydroxy and halo.

8. The compound according to claim 1 of Formula Ic

or a pharmaceutically acceptable salt thereof, wherein:

ring B is heteroaryl;

R 3 is CN, halo or C 1-4 alkyl, optionally substituted with 1-5 halo atoms; and

each R 6 is independently selected from the group consisting of: —CN, halo, —N(R) 2 , C 1-44 alkoxy, —C(O)—O—C 1-4 alkyl, and C 1-4 alkyl, optionally substituted with hydroxy.

9. The compound according to claim 8 or a pharmaceutically acceptable salt thereof, wherein ring B is pyridyl.

10. The compound according to claim 1 of Formula Id

or a pharmaceutically acceptable salt thereof, wherein:

ring C is heterocycle;

R 3 is CN, halo or C 1-4 alkyl, optionally substituted with 1-5 halo atoms; and

each R 7 is independently selected from the group consisting of: OH, acetyl, methylsulfonyl, acetylamino, —C(O)—O—C 1-4 alkyl and C 1-4 alkyl, optionally substituted with 1-3 halo atoms or hydroxy.

11. The compound according to claim 10 or a pharmaceutically acceptable salt thereof, wherein ring C is dioxidothiomorpholin-4-yl.

12. The compound according to claim 10 or a pharmaceutically acceptable salt thereof, wherein ring C is 6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-yl.

13. The compound according to claim 1 of Formula Ie

or a pharmaceutically acceptable salt thereof, wherein:

R 3 is CN, halo or C 1-4 alkyl, optionally substituted with 1-5 halo atoms; and

R 8 is selected from the group consisting of: heteroaryl, heteroarylcarbonyl, methylsulfonyl and C 1-6 alkyl-C(O)—, optionally substituted with 1 to 3 substituents independently selected from halo or hydroxy.

14. The compound according to claim 1 of Formula If

or a pharmaceutically acceptable salt thereof, wherein:

R 3 is CN, halo or C 1-4 alkyl, optionally substituted with 1-5 halo atoms; and

R 9 is selected from the group consisting of: heteroaryl, heteroarylcarbonyl, methylsulfonyl and C 1-6 alkyl-C(O)—, optionally substituted with 1 to 3 substituents independently selected from halo or hydroxy.

15. The compound according to claim 1 of Formula Ih

or a pharmaceutically acceptable salt thereof, wherein:

R 3 is CN, halo or C 1-4 alkyl, optionally substituted with 1-5 halo atoms; and

R 10 is selected from the group consisting of: heteroaryl, heteroarylcarbonyl, methylsulfonyl and C 1-6 alkyl-C(O)—, optionally substituted with 1 to 3 substituents independently selected from halo or hydroxy.

16. The compound according to claim 1 of Formula Ii

or a pharmaceutically acceptable salt thereof, wherein:

R 11 is selected from the group consisting of: heteroaryl and C 1-6 alkyl, optionally substituted with 1 to 3 substituents independently selected from halo or hydroxy.

17. A compound according to claim 1 selected from the following group:

2-[1-(cyclopropylmethyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5b]pyridin-5-yl]benzonitrile;

1-(cyclopropylmethyl)-3-methyl-5-thiophen-2-yl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

3-[1-(cyclopropylmethyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

1-(cyclopropylmethyl)-5-(2-fluorophenyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

2-[1-(cyclopropylmethyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-5-fluorobenzonitrile;

1-(cyclopropylmethyl)-5-[3-(1-hydroxy-1-methylethyl)phenyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

3-[1-(cyclopropylmethyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]pyridine-4-carbonitrile;

1-(cyclopropylmethyl)-5-(2,4-difluorophenyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(cyclopropylmethyl)-5-(4-fluorophenyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-[1-(cyclopropylmethyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-2-fluorobenzonitrile;

1-(cyclopropylmethyl)-5-(4-fluoro-2-methylphenyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

4-[1-(cyclopropylmethyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

5-(2-chlorophenyl)-1-(cyclopropylmethyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(cyclopropylmethyl)-5-(3,5-dichlorophenyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(cyclopropylmethyl)-3-methyl-5-(3-nitrophenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(cyclopropylmethyl)-3-methyl-5-thiophen-3-yl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(cyclopropylmethyl)-5-[2-(dimethylamino)phenyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-(4-fluoro-2-methylphenyl)-3-methyl-1-(4,4,4-trifluorobutyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

2-[3-methyl-2-oxo-1-(4,4,4-trifluorobutyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

5-[3-(1-hydroxy-1-methylethyl)phenyl]-3-methyl-1-(4,4,4-trifluorobutyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-[5-(1-hydroxy-1-methylethyl)-2-methylphenyl]-3-methyl-1-(4,4,4-trifluorobutyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

2-{3-methyl-1-[(1-methylcyclopropyl)methyl]-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl}benzonitrile;

2-[1-(2-cyclopropylethyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

2-{1-[2-fluoro-5-(trifluoromethyl)benzyl]-3-methyl-2-oxo-2,3-dihydro1H-imidazo[4,5-b]pyridin-5-yl}benzonitrile;

2-[1-(4-methoxybenzyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

5-[3-(1-hydroxy-1-methylethyl)phenyl]-3-methyl-1-{[1-(trifluoromethyl)cyclopropyl]methyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-[5-(1-hydroxy-1-methylethyl)-2-methylphenyl]-3-methyl-1-{[1-(trifluoromethyl)cyclopropyl]methyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-(4-fluoro-2-methylphenyl)-3-methyl-1-{[1-(trifluoromethyl)cyclopropyl]methyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

2-(3-methyl-2-oxo-1-{[1-(trifluoromethyl)cyclopropyl]methyl}-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl)benzonitrile;

3-(3-methyl-2-oxo-1-{[1-(trifluoromethyl)cyclopropyl]methyl}-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl)pyridine-4-carbonitrile;

2-(1-{[2,2-difluorocyclopropyl]methyl}-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl)benzonitrile;

1-[(2,2-difluorocyclopropyl)methyl]-5-[5-(1-hydroxy-1-methylethyl)-2-methylphenyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-(5-acetyl-2-methylphenyl)-1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-[(2,2-difluorocyclopropyl)methyl]-5-[3-(1-hydroxy-1-methylethyl)phenyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

methyl-3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl}-4-methylbenzoate;

1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-[2-methyl-5-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

2-(1-{[1-(4-fluorophenyl)-1H-pyrazol-4-yl]methyl}-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl)benzonitrile;

5-chloro-1-{[1-(4-fluorophenyl)-1H-pyrazol-4-yl]methyl}-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-{[1-(4-fluorophenyl)-1H-pyrazol-4-yl]methyl}-5-[3-(1-hydroxy-1-methylethyl)phenyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

3-[1-(2-fluoro-2-methylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]pyridine-4-carbonitrile;

1-(2,2-dimethylpropyl)-5-[5-(1-hydroxy-1-methylethyl)-2-methylphenyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-[4-(methylsulfonyl)phenyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-[2-(trifluoromethyl)phenyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-(3-chlorophenyl)-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(4-fluoropyridin-3-yl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(4-fluoro-2-methylphenyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-(5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(4,5,6,7-tetrahydropyrazlo[1,5-a]pyridin-3-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-(1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(1-methyl-1H-pyrazol-5-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]pyridine-4-carbonitrile;

5-(2,3-dihydro-1-benzofuran-5-yl)-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-[1,2,4]triazolo[4,3-a]pyridin-6-yl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-[1,2,4]triazolo[1,5-a]pyridin-7-yl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(1-methyl-1H-benzotriazol-6-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-(2-cyclopropylphenyl)-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-(3-cyclopropylphenyl)-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-5-methylbenzonitrile;

1-(2,2-dimethylpropyl)-5-[5-(hydroxymethyl)pyridin-3-yl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-[2-(hydroxymethyl)pyridin-4-yl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-quinolin-6-yl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-[2-(3-hydroxy-3-methylbutyl)phenyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-[3-(1-pyrrolidin-1-ylethyl)phenyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-[4-(1-morpholin-4-ylethyl)phenyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-[3-(1,1-dioxidothiomorpholin-4-yl)phenyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-(1-benzyl-1H-pyrazol-5-yl)-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

4-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]thiophene-3-carbonitrile;

5-(1-benzyl-1H-pyrazol-4-yl)-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-[1-(2-methylpropyl)-1H-pyrazol-4-yl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(1-methyl-1H-pyrrol-2-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-quinolin-8-yl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-[3-(morpholin-4-ylmethyl)phenyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-(3-chloro-4-fluorophenyl)-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-[2-(1H-pyrazol-1-yl)phenyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-[3-(1H-pyrazol-1-yl)phenyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-[3-(4-methylpiperazin-1-yl)phenyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-quinolin-5-yl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-[4-(1,1-dioxidothiomorpholin-4-yl)phenyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

ethyl 5-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]pyridine-3-carboxylate;

1-(2,2-dimethylpropyl)-3-methyl-5-[4-(trifluoromethyl)pyridin-3-yl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(4-methoxy-3-methylphenyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-[5-(morpholin-4-ylcarbonyl)pyridin-3-yl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(3-fluoro-2-morpholin-4-ylpyridin-4-yl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]phenyl}acetonitrile;

3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-N,N-dimethylbenzenesulfonamide;

5-[6-(dimethylamino)pyridin-3-yl]-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

tert-butyl ({5-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]pyridin-3-yl}methyl)carbamate;

tert-butyl 4-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]phenyl}piperazine-1-carboxylate;

5-(3-aminophenyl)-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-(4-chloro-2-methylphenyl)-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(3-morpholin-4-ylphenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

tert-butyl 4-{2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]phenyl}piperazine-1-carboxylate;

3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-methoxybenzonitrile;

3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]pyridine-2-carbonitrile;

1-(2,2-dimethylpropyl)-5-(2,4-dimethyl-1,3-thiazol-5-yl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-N,N-dimethylbenzamide;

methyl 3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzoate;

tert-butyl {3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzyl}carbamate;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-methylbenzonitrile;

1-(2,2-dimethylpropyl)-5-(2-fluoro-6-methylpyridin-3-yl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(6-fluoro-2-methylpyridin-3-yl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(4-methyl-2-phenyl-1,3-thiazol-5-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-[3-(hydroxymethyl)phenyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

methyl 3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-fluorobenzoate;

methyl 4-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-3-fluorobenzoate;

ethyl 3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-2-fluorobenzoate;

methyl 3-chloro-5-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzoate;

1-(2,2-dimethylpropyl)-3-methyl-5-phenyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

1-(2,2-dimethylpropyl)-5-[3-(1-hydroxy-1-methylethyl)phenyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-{4-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzyl}-3-methylimidazolidine-2,4-dione;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-6-(trifluoromethyl)benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-5-fluorobenzonitrile;

1-(2,2-dimethylpropyl)-5-(3-fluoro-4-methylphenyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-pyridin-3-yl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-3-methoxybenzonitrile;

5-[4-(aminomethyl)phenyl]-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-5-(trifluoromethyl)benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-6-methoxybenzonitrile;

3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

5-(2,4-difluorophenyl)-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(2-fluorophenyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

4-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

1-(2,2-dimethylpropyl)-3-methyl-5-(4-methylphenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(4-fluorophenyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(3-methoxyphenyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(2-methoxyphenyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(2-methylphenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-naphthalen-2-yl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(3-methylphenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-[4-(hydroxymethyl)phenyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-(3-acetylphenyl)-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-methylbenzonitrile;

1-(2,2-dimethylpropyl)-3-methyl-5-(4-oxo-3,4-dihydro-2H-chromen-6-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-(hydroxylmethyl)benzonitrile;

methyl 3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-methylbenzoate;

1-(2,2-dimethylpropyl)-5-[2-fluoro-3-(1H-pyrazol-5-yl)phenyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(3-oxo-2,3-dihydro-1H-inden-5-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-(5-acetyl-2-methylphenyl)-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

4-{4-cyano-3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]phenoxy}pyridine-2-carbonitrile;

6-{4-cyano-3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]phenoxy}pyridine-3-carbonitrile;

6-{4-cyano-3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]phenoxy}pyridine-2-carbonitrile;

4-{4-cyano-3-[1-(cyclopropylmethyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]phenoxy}pyridine-2-carbonitrile;

4-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]phenoxy}pyridine-2-carbonitrile;

1-(2,2-dimethylpropyl)-3-methyl-5-[3-(pyridin-2-yloxy)phenyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

6-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]phenoxy}pyridine-3-carbonitrile;

4-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]phenoxy}pyridine-3-carbonitrile;

6-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]phenoxy}pyridine-3-carbonitrile;

6-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]phenoxy}pyridine-2-carbonitrile;

2-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]phenoxy}pyridine-4-carbonitrile;

2-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]phenoxy}pyridine-3-carbonitrile;

4-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-methylphenoxy}pyridine-2-carbonitrile;

6-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-methylphenoxy}pyridine-3-carbonitrile;

4-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-methylphenoxy}pyridine-3-carbonitrile;

1-(2,2-dimethylpropyl)-5-[3-(1-hydroxy-1-phenylethyl)phenyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-(pyrrolidin-1-ylmethyl)benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-(morpholin-4-ylmethyl)benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(2-oxo-1,3-oxazolidin-3-yl)methyl]benzonitrile;

4-({[2-(dimethylamino)ethyl]amino}methyl)-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(4-hydroxypiperidin-1-yl)methyl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[(2-hydroxyethyl)amino]methyl}benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(3-hydroxypiperidin-1-yl)methyl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[(3-hydroxy-2,2-dimethylpropyl)amino]methyl}benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(4-methylpiperazin-1-yl)methyl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(1,1-dioxidothiomorpholin-4-yl)methyl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(3-hydroxypyrrolidin-1-yl)methyl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(2-methyl-1-oxo-2,8-diazaspiro[4.5]dec-8-yl)methyl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[8-methyl-3-(trifluoromethyl)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]methyl}benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(1-oxidothiomorpholin-4-yl)methyl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[(2R,4R)-4-hydroxy-2-methylpyrrolidin-1-yl]methyl}benzonitrile;

4-(8-azabicyclo[3.2.1]oct-8-ylmethyl)-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]hept-5-ylmethyl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[2-(trifluoromethyl)piperidin-1-yl]methyl}benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-({[3-(3,5-dimethyl-1H-pyrazol-1-yl)benzyl](methyl)amino}methyl)benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-({methyl[2-(4-methylpiperazin-1-yl)ethyl]amino}methyl)benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[3-(trifluoromethyl)-1,5,6,7-tetrahydro-4H-pyrazolo[4,3-b]pyridin-4-yl]methyl}benzonitrile;

4-(6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-ylmethyl)-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[3-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]methyl}benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]methyl}benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-({[1-(methylsulfonyl)piperidin-4-yl]amino}methyl)benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(3-hydroxy-3-phenylpyrrolidin-1-yl)methyl]benzonitrile;

2-({4-cyano-3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzyl}amino)-N,N-dimethylethanesulfonamide;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[2-(trifluoromethyl)morpholin-4-yl]methyl}benzonitrile;

4-{[(3S,4S)-3,4-difluoropyrrolidin-1-yl]methyl}-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[(2R)-2-(trifluoromethyl)pyrrolidin-1-yl]methyl}benzonitrile;

tert-butyl (3-{4-cyano-3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzyl}-3-azabicyclo[3.1.0]hex-6-yl)carbamate;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(3-oxo-1,4-diazepan-1-yl)methyl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[4-(methylsulfonyl)piperidin-1-yl]methyl}benzonitrile;

4-({4-[dimethyl(phenyl)silyl]piperidin-1-yl}methyl)-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

4-[(3,3-difluoropyrrolidin-1-yl)methyl]-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

4-[(3,3-difluoroazetidin-1-yl)methyl]-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

4-[(3,3-dimethoxypyrrolidin-1-yl)methyl]-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

4-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-ylmethyl)-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[(2S)-2-(trifluoromethyl)pyrrolidin-1-yl]methyl}benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-({4-[hydroxy(pyridin-3-yl)methyl]piperidin-1-yl}methyl)benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-({4-[(3-hydroxyphenyl)sulfonyl]piperazin-1-yl}methyl)benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[4-(1,1-dioxidotetrahydrothiophen-3-yl)piperazin-1-yl]methyl}benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[3-(trifluoromethyl)piperidin-1-yl]methyl}benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[4-(methylsulfonyl)piperazin-1-yl]methyl}benzonitrile;

tert-butyl 5-{4-cyano-3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzyl}-2,5-diazabicyclo[2.2.2]octane-2-carboxylate;

4-[(4-acetylpiperazin-1-yl)methyl]-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

1-{4-cyano-3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzyl}piperidine-4-carboxamide;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(4-hydroxy-4-phenylpiperidin-1-yl)methyl]benzonitrile;

ethyl 4-({4-cyano-3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzyl}amino)piperidine-1-carboxylate;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[4-(4-methyl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(5-oxo-1,4-diazepan-1-yl)methyl]benzonitrile;

4-(3,4-dihydroisoquinolin-2(1H)-ylmethyl)-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

4-(3,4-dihydroquinolin-1(2H)-ylmethyl)-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[1-methyl-3-(trifluoromethyl)-1,5,6,7-tetrahydro-4H-pyrazolo[4,3-b]pyridin-4-yl]methyl}benzonitrile;

4-[(2-cyclopropyl-6,7-dihydro[1,3]oxazolo[4,5-c]pyridin-5(4H)-yl)methyl]-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]methyl}benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[5,5-dimethyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]methyl}benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[2-(trifluoromethyl)-6,7-dihydro[1,3]thiazolo[4,5-c]pyridin-5(4H)-yl]methyl}benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(2-phenyl-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)methyl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(2-methyl-6,7-dihydro[1,3]oxazolo[5,4-c]pyridin-5(4H)-yl)methyl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(2-methyl-6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-5(4H)-yl)methyl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-(1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-ylmethyl)benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(3-methyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)methyl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[3-(4-fluorophenyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]methyl}benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(3-methoxy-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methyl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[8-methyl-2-(trifluoromethyl)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]methyl}benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]methyl}benzonitrile;

ethyl 7-{4-cyano-3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine-3-carboxylate;

ethyl 7-{4-cyano-3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzyl}-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[1-methyl-3-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]methyl}benzonitrile;

4-(5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-ylmethyl)-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[1-methyl-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]methyl}benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[8-methyl-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]methyl}benzonitrile;

4-[(3-cyclopropyl-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)methyl]-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

4-[(2-cyclopropyl-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)methyl]-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]methyl}benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(3-hydroxy-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl)methyl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[2-(trifluoromethyl)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]methyl}benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(1-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methyl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(3-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)methyl]benzonitrile;

4-[(3-benzyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)methyl]-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(1-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methyl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(1,1-dioxido-1,4-thiazepan-4-yl)methyl]benzonitrile;

tert-butyl [(2R,4S)-1-{4-cyano-3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzyl}-2-(trifluoromethyl)piperidin-4-yl]carbamate;

tert-butyl [(2S,4S)-1-{4-cyano-3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzyl}-2-(trifluoromethyl)piperidin-4-yl]carbamate;

4-[(3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl)methyl]-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[4-(2,2,2-trifluoroethyl)piperazin-1-yl]methyl}benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzonitrile;

4-{[{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(ethyl)amino]methyl}-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(3-hydroxy-3-methylpyrrolidin-1-yl)methyl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(3-hydroxy-3-methylpiperidin-1-yl)methyl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[4-(5-methyl-1H-imidazol-1-yl)piperidin-1-yl]methyl}benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[4-(5-methyl-1,2,4-thiadiazol-3-yl)piperidin-1-yl]methyl}benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(2-methyl-5-oxo-1,4-diazepan-1-yl)methyl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[3-(1H-pyrazol-1-yl)pyrrolidin-1-yl]methyl}benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(2-oxo-1,2-dihydro-1′H-spiro[3,1-benzoxazine-4,4′-piperidin]-1′-yl)methyl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-(hexahydro-4H-furo[3,2-b]pyrrol-4-ylmethyl)benzonitrile;

4-[(3,3-difluoropiperidin-1-yl)methyl]-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(3-propoxy-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl)methyl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(3-ethoxy-7-methyl-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl)methyl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(3-ethyl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methyl]benzonitrile;

4-[(2-cyclopropyl-6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-5(4H)-yl)methyl]-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[7-methyl-3-(1-methylethoxy)-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl]methyl}benzonitrile;

ethyl 2-{4-cyano-3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzyl}-1,2,3,4-tetrahydroisoquinoline-1-carboxylate;

methyl 2-{4-cyano-3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylate;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(3-hydroxy-4,7-dihydroisoxazolo[5,4-c]pyridin-6(5H)-yl)methyl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]methyl}benzonitrile;

tert-butyl (1R,4R)-5-{4-cyano-3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzyl}-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate;

tert-butyl (1S,4S)-5-{4-cyano-3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzyl}-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-ylmethyl]benzonitrile;

tert-butyl 4-{4-cyano-3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzyl}piperazine-1-carboxylate;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[3-(4-methyl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}benzonitrile;

4-{[3-(1H-benzimidazol-2-yl)piperidin-1-yl]methyl}-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[4-(1H-pyrazol-1-yl)piperidin-1-yl]methyl}benzonitrile;

2-(3-methyl-2-oxo-1-prop-2-en-1-yl-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl)-4-{[7-methyl-3-(prop-2-en-1-yloxy)-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl]methyl}benzonitrile;

tert-butyl 3-{4-cyano-3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzyl}-3,8-diazabicyclo[3.2.1]octane-8-carboxylate;

4-(7,8-dihydro-1,6-naphthyridin-6(5H)-ylmethyl)-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

tert-butyl (3R)-4-{4-cyano-3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzyl}-3-methylpiperazine-1-carboxylate;

tert-butyl (3S)-4-{4-cyano-3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzyl}-3-methylpiperazine-1-carboxylate;

4-[(2-cyclopropyl-6,7-dihydro[1,3]oxazolo[4,5-c]pyridin-5(4H)-yl)methyl]-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

4-(3,4-dihydro-2,6-naphthyridin-2(1H)-ylmethyl)-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

4-(3,4-dihydro-2,7-naphthyridin-2(1H)-ylmethyl)-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(2-methyl-6,7-dihydro[1,3]oxazolo[4,5-c]pyridin-5(4H)-yl)methyl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(7-hydroxy-6-methoxy-3,4-dihydroisoquinolin-2(1H)-yl)methyl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(4-methyl-3-oxopiperazin-1-yl)methyl]benzonitrile;

4-(5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-ylmethyl)-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

4-({6-[(dimethylamino)methyl]-3,4-dihydroisoquinolin-2(1H)-yl}methyl)-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[4-(isoquinolin-5-ylamino)piperidin-1-yl]methyl}benzonitrile;

1-(2,2-dimethylpropyl)-5-(2-fluoropyridin-3-yl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(6-fluoropyridin-2-yl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(2-fluoro-5-methylpyridin-3-yl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(6-methylpyridin-2-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(3-methylpyridin-2-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(6-methoxypyridin-2-yl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(5-methyl-1,3-thiazol-2-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

2-methylpropyl {3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzyl}carbamate;

benzyl {3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzyl}carbamate;

methyl {3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzyl}carbamate;

ethyl {3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzyl}carbamate;

N-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzyl}acetamide;

N-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzyl}-2,2,2-trifluoroethanesulfonamide;

2-methylpropyl {3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzyl}methylcarbamate;

1-(2,2-dimethylpropyl)-5-{5-[(1S)-1-hydroxyethyl]-2-methylphenyl}-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-[2-methyl-5-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-[3-hydroxy-3-(trifluoromethyl)-2,3-dihydro-1H-inden-5-yl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-[4-hydroxy-4-(trifluoromethyl)-3,4-dihydro-2H-chromen-6-yl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-[4-hydroxy-3,4-dihydro-2H-chromen-6-yl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[1-hydroxyethyl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-(1-hydroxy-1-methylethyl)benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzonitrile;

2-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]phenyl}propanenitrile;

2-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]phenyl}-2-methylpropanenitrile;

1-(2,2-dimethylpropyl)-5-{4-[1-hydroxyethyl]-2-methylphenyl}-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-[4-(1-hydroxy-1-methylethyl)-2-methylphenyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-{5-[1-(1,1-dioxidothiomorpholin-4-yl)ethyl]-2-methylphenyl}-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(5-{1-[3-hydroxypyrrolidin-1-yl]ethyl}-2-methylphenyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-[3-(2-hydroxypropan-2-yl)phenyl]-3,7-dimethyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(1R)-1-(1,1-dioxidothiomorpholin-4-yl)ethyl]benzonitrile;

1-(2,2-dimethylpropyl)-5-{5-[(1R)-1-(1,1-dioxidothiomorpholin-4-yl)ethyl]-2-methylphenyl}-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-{5-[(1S)-1-(1,1-dioxidothiomorpholin-4-yl)ethyl]-2-methylphenyl}-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

Methyl [(1R)-1-{4-cyano-3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]phenyl}ethyl]carbamate;

N-[(1R)-1-{4-cyano-3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]phenyl}ethyl]-2,2,2-trifluoroethanesulfonamide;

Methyl (1-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-methylphenyl}-1-methylethyl)carbamate;

N-(1-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-methylphenyl}-1-methylethyl)-2,2,2-trifluoroethanesulfonamide;

2-fluoroethyl (2-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-methylphenyl}propan-2-yl)carbamate;

N-(2-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-methylphenyl}propan-2-yl)pyridine-3-carboxamide;

N-(2-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-methylphenyl}propan-2-yl)-1,2,3-thiadiazole-4-carboxamide;

1-(2,2-dimethylpropyl)-5-{5-[1-(1,1-dioxidothiomorpholin-4-yl)-1-methylethyl]-2-methylphenyl}-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[(1R,4R)-5-(methylsulfonyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl}benzonitrile;

4-{[(1R,4R)-5-acetyl-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl}-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

4-[(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-ylmethyl]-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[(1S,4S)-5-(methylsulfonyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl}benzonitrile;

4-{[(1S,4S)-5-acetyl-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl}-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

4-(2,5-diazabicyclo[2.2.2]oct-2-ylmethyl)-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[5-(methylsulfonyl)-2,5-diazabicyclo[2.2.2]oct-2-yl]methyl}benzonitrile;

4-[(5-acetyl-2,5-diazabicyclo[2.2.2]oct-2-yl)methyl]-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

4-(3,8-diazabicyclo[3.2.1]oct-3-ylmethyl)-2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-{[8-(methylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl]methyl}benzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-(piperazin-1-ylmethyl)benzonitrile;

5-{3-[(4-acetylpiperazin-1-yl)methyl]phenyl}-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(3-{[4-(methylsulfonyl)piperazin-1-yl]methyl}phenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{3-[(3-oxopiperazin-1-yl)methyl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-{3-[(5-oxo-1,4-diazepan-1-yl)methyl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{3-[(4-methyl-5-oxo-1,4-diazepan-1-yl)methyl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-{3-[(4-acetyl-1,4-diazepan-1-yl)methyl]phenyl}-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(3-{[4-(methylsulfonyl)-1,4-diazepan-1-yl]methyl}phenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

tert-butyl 4-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzyl}piperazine-1-carboxylate;

1-(2,2-dimethylpropyl)-3-methyl-5-(3-{[4-(2-methylpropanoyl)piperazin-1-yl]methyl}phenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-(3-{[4-(2,2-dimethylpropanoyl)piperazin-1-yl]methyl}phenyl)-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(3-{[4-(2-hydroxy-2-methylpropanoyl)piperazin-1-yl]methyl}phenyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(3-{[4-(ethylsulfonyl)piperazin-1-yl]methyl}phenyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{3-[(4-methyl-3-oxopiperazin-1-yl)methyl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-[3-({4-[(2,2-difluorocyclopropyl)methyl]piperazin-1-yl}methyl)phenyl]-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-(3-{[4-(cyclobutylmethyl)piperazin-1-yl]methyl}phenyl)-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-(3-{[4-(cyclopropylsulfonyl)piperazin-1-yl]methyl}phenyl)-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-[3-({4-[(1-methylethyl)sulfonyl]piperazin-1-yl}methyl)phenyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]methyl}phenyl)-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-[3-({4-[(2,2-difluorocyclopropyl)carbonyl]piperazin-1-yl}methyl)phenyl]-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(3-{[4-(trifluoroacetyl)piperazin-1-yl]methyl}phenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{3-[(4-propanoylpiperazin-1-yl)methyl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-(3-{[4-(cyclobutylcarbonyl)piperazin-1-yl]methyl}phenyl)-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-(3-{[4-(2,2-difluoropropanoyl)piperazin-1-yl]methyl}phenyl)-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-(3-{[4-(cyclopropylmethyl)-3-oxopiperazin-1-yl]methyl}phenyl)-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-{3-[(4-ethyl-3-oxopiperazin-1-yl)methyl]phenyl}-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-[3-({4-[(2,2-difluorocyclopropyl)methyl]-3-oxopiperazin-1-yl}methyl)phenyl]-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-(3-{[4-(cyclobutylmethyl)-3-oxopiperazin-1-yl]methyl}phenyl)-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(3-{[4-(2-methylpropyl)-3-oxopiperazin-1-yl]methyl}phenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-[5-(1-cyclopropyl-1-hydroxyethyl)-2-methylphenyl]-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(2-methyl-5-{[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]methyl}phenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-{5-[(3-hydroxy-3-methylpiperidin-1-yl)methyl]-2-methylphenyl}-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

tert-butyl (1R,4R)-5-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-methylbenzyl}-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate;

1-(2,2-dimethylpropyl)-3-methyl-5-(2-methyl-5-{[3-(1H-pyrazol-1-yl)piperidin-1-yl]methyl}phenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-{5-[(3-hydroxy-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl)methyl]-2-methylphenyl}-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

tert-butyl 4-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-methylbenzyl}piperazine-1-carboxylate;

5-{5-[(4-acetylpiperazin-1-yl)methyl]-2-methylphenyl}-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(2-methyl-5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}phenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-{5-[(1,1-dioxidothiomorpholin-4-yl)methyl]-2-methylphenyl}-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-methylbenzyl}-3-methylimidazolidine-2,4-dione;

1-(2,2-dimethylpropyl)-3-methyl-5-(2-methyl-5-{[(1R,4R)-5-(methylsulfonyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl}phenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(5-{[4-(isoxazol-3-ylcarbonyl)piperazin-1-yl]methyl}-2-methylphenyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

methyl 4-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-methylbenzyl}piperazine-1-carboxylate;

1-(2,2-dimethylpropyl)-5-[5-({4-[(2R)-2-hydroxypropanoyl]piperazin-1-yl}methyl)-2-methylphenyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(5-{[4-(hydroxyacetyl)piperazin-1-yl]methyl}-2-methylphenyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-{5-[1-(4-acetylpiperazin-1-yl)ethyl]-2-methylphenyl}-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(2-methyl-5-{1-[4-(methylsulfonyl)piperazin-1-yl]ethyl}phenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-N,4-dimethylbenzamide;

3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-N,N,4-trimethylbenzamide;

N-(cyclopropylmethyl)-3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-methylbenzamide;

5-[5-(6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-ylcarbonyl)-2-methylphenyl]-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-N-(isoxazol-4-ylmethyl)-4-methylbenzamide;

N-[(3-cyanoisoxazol-4-yl)methyl]-3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-methylbenzamide;

1-(2,2-dimethylpropyl)-5-{5-[(1,1-dioxidothiomorpholin-4-yl)carbonyl]-2-methylphenyl}-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-[2-methyl-5-(morpholin-4-ylcarbonyl)phenyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-{5-[(3-hydroxy-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl)carbonyl]-2-methylphenyl}-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-{5-[(4-acetylpiperazin-1-yl)methyl]-2-methylphenyl}-1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-(2-methyl-5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}phenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-[(2,2-difluorocyclopropyl)methyl]-5-(5-{[4-(2-hydroxy-2-methylpropanoyl)piperazin-1-yl]methyl}-2-methylphenyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-[2-fluoro-5-(1-hydroxy-1-methylethyl)phenyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(2-fluoro-5-{[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]methyl}phenyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-{2-fluoro-5-[(3-hydroxy-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H) yl)methyl]phenyl}-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one

5-{5-[(4-acetylpiperazin-1-yl)methyl]-2-fluorophenyl}-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(2-fluoro-5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}phenyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(2-fluoro-5-{[4-(2,2,2-trifluoroethyl)piperazin-1-yl]methyl}phenyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(2-fluoro-4-{[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazoio[4,3-a]pyrazin-7(8H)-yl]methyl}phenyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-{4-[(4-acetylpiperazin-1-yl)methyl]-2-fluorophenyl}-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(2-fluoro-4-{[4-(methylsulfonyl)piperazin-1-yl]methyl}phenyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-[2-fluoro-3-(1-hydroxy-1-methylethyl)phenyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(2-fluoro-3-{[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]methyl}phenyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-{2-fluoro-3-[(3-hydroxy-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl)methyl]phenyl}-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-{3-[(4-acetylpiperazin-1-yl)methyl]-2-fluorophenyl}-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(2-fluoro-3-{[4-(methylsulfonyl)piperazin-1-yl]methyl}phenyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(2-fluoro-3-{[4-(2,2,2-trifluoroethyl)piperazin-1-yl]methyl}phenyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-[3-chloro-5-(1-hydroxy-1-methylethyl)phenyl]-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-(3-chloro-5-{[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]methyl}phenyl)-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-{3-[(4-acetylpiperazin-1-yl)methyl]-5-chlorophenyl}-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-(3-chloro-5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}phenyl)-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{2-methyl-5-[1-(pyridin-3-ylcarbonyl)-1,2,3,6-tetrahydropyridin-4-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{3-[1-(pyridin-3-ylcarbonyl)piperidin-3-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-{3-[1-(isoxazol-3-ylcarbonyl)piperidin-3-yl]phenyl}-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-{3-[1-(2-hydroxypropanoyl)piperidin-3-yl]phenyl}-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{3-[4-(pyridin-3-ylcarbonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-{3-[4-(isoxazol-3-ylcarbonyl)piperazin-1-yl]phenyl}-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{3-[4-(1,3-oxazol-2-ylcarbonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(3-{4-[(ethylsulfonyl)acetyl]piperazin-1-yl}phenyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{3-[4-(3-methylbutanoyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{3-[4-(1,2,3-thiadiazol-4-ylcarbonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{3-[4-(tetrahydro-2H-pyran-2-ylcarbonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-{3-[4-(isothiazol-4-ylcarbonyl)piperazin-1-yl]phenyl}-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-[3-(4-acetylpiperazin-1-yl)phenyl]-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-{3-[4-(cyclopentylcarbonyl)piperazin-1-yl]phenyl}-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{3-[4-(1,3-oxazol-5-ylcarbonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{3-[4-(1,3-thiazol-5-ylcarbonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(3-{4-[(1-methyl-1H-pyrazol-3-yl)carbonyl]piperazin-1-yl}phenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{3-[4-(1H-1,2,4-triazol-5-ylcarbonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(3-{4-[(1-methyl-1H-pyrazol-5-yl)carbonyl]piperazin-1-yl}phenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-{3-[4-(3,3-dimethylbutanoyl)piperazin-1-yl]phenyl}-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{3-[4-(thiophen-2-ylcarbonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-{3-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]phenyl}-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{3-[4-(1H-pyrazol-1-ylacetyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{3-[4-(1H-pyrazol-4-ylcarbonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{3-[4-(1,2,5-thiadiazol-3-ylcarbonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{3-[4-(phenylcarbonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(3-{4-[(1-methyl-1H-imidazol-2-yl)carbonyl]piperazin-1-yl}phenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(3-{4-[2-(1H-1,2,4-triazol-1-yl)propanoyl]piperazin-1-yl}phenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(3-{4-[(1-methyl-1H-imidazol-4-yl)carbonyl]piperazin-1-yl}phenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{3-[4-(thiophen-3-ylacetyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{3-[4-(tetrahydrofuran-3-ylcarbonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(3-{4-[(5-methyl-1,3-thiazol-4-yl)carbonyl]piperazin-1-yl}phenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{3-[4-(tetrahydro-2H-pyran-4-ylcarbonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{3-[4-(1,2,5-oxadiazol-3-ylcarbonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{3-[4-(phenylacetyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{3-[4-(methylsulfonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{4-[4-(methylsulfonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

2-fluoroethyl 4-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]phenyl}piperazine-1-carboxylate;

methyl 4-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]phenyl}piperazine-1-carboxylate;

1-(2,2-dimethylpropyl)-3-methyl-5-{4-[4-(pyridin-3-ylcarbonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(4-{4-[(ethylsulfonyl)acetyl]piperazin-1-yl}phenyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{4-[4-(3-methylbutanoyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(4-{4-[(1-methyl-1H-pyrazol-3-yl)carbonyl]piperazin-1-yl}phenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-{4-[4-(isoxazol-3-ylcarbonyl)piperazin-1-yl]phenyl}-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{4-[4-(1,2,5-oxadiazol-3-ylcarbonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-{4-[4-(3,3-dimethylbutanoyl)piperazin-1-yl]phenyl}-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-{4-[4-(isothiazol-4-ylcarbonyl)piperazin-1-yl]phenyl}-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{4-[4-(thiophen-3-ylacetyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{4-[4-(1,3-thiazol-5-ylcarbonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{4-[4-(1,3-oxazol-5-ylcarbonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{4-[4-(1H-pyrazol-4-ylcarbonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(4-{4-[(1-methyl-1H-imidazol-2-yl)carbonyl]piperazin-1-yl}phenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-{4-[4-(cyclopentylcarbonyl)piperazin-1-yl]phenyl}-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{4-[4-(tetrahydro-2H-pyran-4-ylcarbonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(4-{4-[(5-methyl-1,3-thiazol-4-yl)carbonyl]piperazin-1-yl}phenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(4-{4-[(1-methyl-1H-pyrazol-5-yl)carbonyl]piperazin-1-yl}phenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{4-[4-(tetrahydro-2H-pyran-2-ylcarbonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{4-[4-(1,2,3-thiadiazol-4-ylcarbonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{4-[4-(1H-pyrazol-1-ylacetyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-[4-(4-acetylpiperazin-1-yl)phenyl]-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{4-[4-(1H-1,2,4-triazol-5-ylcarbonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(4-{4-[2-(1H-1,2,4-triazol-1-yl)propanoyl]piperazin-1-yl}phenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{4-[4-(1,3-thiazol-4-ylcarbonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-{4-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]phenyl}-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{4-[4-(tetrahydrofuran-3-ylcarbonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{4-[4-(phenylcarbonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-{4-[4-(thiophen-2-ylcarbonyl)piperazin-1-yl]phenyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-[5-(1-hydroxy-1-methylethyl)pyridin-3-yl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-Dimethylpropyl)-5-[5-(1-hydroxy-1-methylethyl)-2-methylphenyl]-3-prop-2-en-1-yl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(2-fluorophenyl)-3-prop-2-en-1-yl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

2-[1-(2,2-dimethylpropyl)-2-oxo-3-prop-2-en-1-yl-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

2-{1-[(2,2-difluorocyclopropyl)methyl]-2-oxo-3-prop-2-en-1-yl-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl}benzonitrile;

2-[1-(2,2-dimethylpropyl)-2-oxo-3-prop-2-en-1-yl-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzaldehyde;

2-[1-(2,2-dimethylpropyl)-2-oxo-3-prop-2-en-1-yl-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-[(1,1-dioxidothiomorpholin-4-yl)methyl]benzonitrile;

4-[(3-hydroxy-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl)methyl]-2-(3-methyl-2-oxo-1-prop-2-en-1-yl-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl)benzonitrile;

1-(2,2-dimethylpropyl)-3-methyl-5-[2-methyl-5-(pyridin-4-yl)phenyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-[2-methyl-5-(3-methyl-1H-pyrazol-4-yl)phenyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-[2-methyl-5-(4-methylpyridin-3-yl)phenyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

4-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-methylphenyl}pyridine-2-carbonitrile;

1-(2,2-dimethylpropyl)-3-methyl-5-[2-methyl-5-(1H-pyrazol-3-yl)phenyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-[2-methyl-5-(1H-pyrrol-2-yl)phenyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-[3-(1H-pyrazol-5-yl)phenyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-[5-(5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-2-methylphenyl]-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-[5-(5-fluoropyridin-3-yl)-2-methylphenyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-(3′-hydroxy-4-methylbiphenyl-3-yl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-[5′-(1-hydroxy-1-methylethyl)-2′,4-dimethylbiphenyl-3-yl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

2-{1-[(2,2-difluoro-1-methylcyclopropyl)methyl]-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl}benzonitrile;

1-[(2,2-difluoro-1-methylcyclopropyl)methyl]-5-[5-(1-hydroxy-1-methylethyl)-2-methylphenyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-[(2,2-difluoro-1-methylcyclopropyl)methyl]-5-[3-(1,1-dioxidothiomorpholin-4-yl)phenyl]-3-methyl 1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

tert-butyl [1-(4-{1-[(2,2-difluoro-1-methylcyclopropyl)methyl]-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl}phenyl)cyclobutyl]carbamate;

5-[4-(1-aminocyclobutyl)phenyl]-1-[(2,2-difluoro-1-methylcyclopropyl)methyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1,1′-bis[(2,2-difluoro-1-methylcyclopropyl)methyl]-3,3′-dimethyl-1,1′,3,3′-tetrahydro-2H,2′H-5,5′-biimidazo[4,5-b]pyridine-2,2′-dione;

tert-butyl [3-(1-{[(1S)-2,2-difluoro-1-methylcyclopropyl]methyl}-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl)benzyl]carbamate;

tert-butyl 7-(1-{[(1S)-2,2-difluoro-1-methylcyclopropyl]methyl}-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate;

1-{[(1S)-2,2-difluoro-1-methylcyclopropyl]methyl}-5-[5-(1-hydroxy-1-methylethyl)-2-methylphenyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-[(2,2-difluoro-1-methylcyclopropyl)methyl]-5-(1H-indol-5-yl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-[(2,2-difluoro-1-methylcyclopropyl)methyl]-3-methyl-5-[3-(1H-pyrazol-1-yl)phenyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-[(2,2-difluoro-1-methylcyclopropyl)methyl]-3-methyl-5-quinolin-8-yl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-[(2,2-difluoro-1-methylcyclopropyl)methyl]-3-methyl-5-(1-methyl-1H-indol-5-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-[(2,2-difluoro-1-methylcyclopropyl)methyl]-5-(1H-indol-6-yl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-[(2,2-difluoro-1-methylcyclopropyl)methyl]-5-(1H-indazol-5-yl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-[(2,2-difluoro-1-methylcyclopropyl)methyl]-3-methyl-5-(3-methyl-1,2-benzisoxazol-5-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-[(2,2-difluoro-1-methylcyclopropyl)methyl]-3-methyl-5-(2-methyl-5-pyridin-3-ylphenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-{[(1R)-2,2-difluoro-1-methylcyclopropyl]methyl}3-methyl-5-[2-methyl-5-(1H-pyrazol-5-yl)phenyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-{[(1R)-2,2-difluoro-1-methylcyclopropyl]methyl}-5-[5-(1,1-dioxidothiomorpholin-4-yl)-2-methylphenyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

4-(3-{1-[(2,2-difluoro-1-methylcyclopropyl)methyl]-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl}-4-methylphenyl)pyridine-2-carbonitrile;

2-[3-methyl-2-oxo-1-(4,4,4-trifluoro-2,2-dimethylbutyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]benzonitrile;

5-[5-(1-hydroxy-1-methylethyl)-2-methylphenyl]-3-methyl-1-(4,4,4-trifluoro-2,2-dimethylbutyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-(1H-indol-5-yl)-3-methyl-1-(4,4,4-trifluoro-2,2-dimethylbutyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

3-methyl-5-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1-(4,4,4-trifluoro-2,2-dimethylbutyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-(3-bromo-1H-indol-5-yl)-3-methyl-1-(4,4,4-trifluoro-2,2-dimethylbutyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-(2,3-dibromo-1H-indol-5-yl)-3-methyl-1-(4,4,4-trifluoro-2,2-dimethylbutyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-[3-(1,1-dioxidothiomorpholin-4-yl)phenyl]-3-methyl-1-(4,4,4-trifluoro-2,2-dimethylbutyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-(1-benzofuran-5-yl)-3-methyl-1-(4,4,4-trifluoro-2,2-dimethylbutyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

3-methyl-5-(3-phenyl-1H-indol-5-yl)-1-(4,4,4-trifluoro-2,2-dimethylbutyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

2-(1-biphenyl-3-yl-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl)benzonitrile;

1-(2,2-dimethylpropyl)-3-methyl-5-(2-methyl-5-{[5-(2,2,2-trifluoroethyl)-2,5-diazabicyclo[2.2.2]oct-2-yl]methyl}phenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-3-methyl-5-(4-{[4-(methylsulfonyl)piperazin-1-yl]methyl}phenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-{3-[cyclopropyl(hydroxy)methyl]phenyl}-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-[3-(1-hydroxy-2-methylpropyl)phenyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

5-{5-[cyclopropyl(hydroxy)methyl]-2-methylphenyl}-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-[5-(1-hydroxy-2-methylpropyl)-2-methylphenyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-(2,2-dimethylpropyl)-5-[5-(2-hydroxy-2-methylpropyl)-2-methylphenyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one; and

N-(2-{3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-methylphenyl}ethyl)-2-hydroxypropanamide;

or a pharmaceutically acceptable salt thereof.

18. A pharmaceutical composition comprising a compound according to claim 1 or a pharmaceutically acceptable salt thereof in combination with a pharmaceutically acceptable carrier.

19. A method for treating a neurological or psychiatric disorder associated with glutamate dysfunction in a patient in need thereof, wherein the neurological or psychiatric disorder associated with glutamate dysfunction is schizophrenia, the method comprising administering to the patient a therapeutically effective amount of a compound according to claim 1 or a pharmaceutically acceptable salt thereof.

Assignments (1)

MERGER Recorded Aug 8, 2022

From: MERCK SHARP & DOHME CORP.

To: MERCK SHARP & DOHME LLC

Reel/Frame 061102/0145 →