Method of inhibiting Alu RNA and therapeutic uses thereof
View Patent ↗The presently-disclosed subject matter includes methods of identifying an Alu RNA inhibitor, and methods and compositions for inhibiting Alu RNA. Methods and compositions can be used for the treatment of geographic atrophy and other conditions of interest.
1. A method of protecting a retinal pigmented epithelium (RPE) cell, comprising: inhibiting Alu RNA associated with the RPE cell, wherein the inhibiting Alu RNA comprises administering an siRNA targeting Alu RNA.
2. The method of claim 1 , wherein the siRNA includes a first strand having a sequence selected from SEQ ID NO: 1, 2, 3, 4, 5, and 6.
3. The method of claim 1 , wherein the RPE cell is of a subject having age-related macular degeneration.
4. The method of claim 1 , wherein the RPE cell is of a subject having geographic atrophy.