Tunable phenylacetylene hosts
A compound, or a salt thereof, having the formula wherein Y is n is 1 or 2; each R is independently H, alkyl, substituted alkyl, a polyether moiety, carboxyl, substituted carboxyl, carbamate, substituted carbonate, carbonyloxy, alkoxy, substituted alkoxy, haloalkyl, halogen, nitro, amino, aryloxy, cyano, hydroxyl, or sulfonyl; R 1 is H, lower alkyl or aralkyl; R 2 is selected from H, acyl, aralkyl, phosphonyl, —SO 2 R 3 ; —C(O)R 5 ; —C(O)OR 7 or —C(O)NR 9 R 10 ; R 3 ; R 5 ; R 7 ; R 9 and R 10 independently are selected from H, lower alkyl, aralkyl or aryl; and R 20 is selected from alkyl, substituted alkyl, a polyether moiety, carboxyl, substituted carboxyl, carbamate, substituted carbonate, carbonyloxy, alkoxy, substituted alkoxy, haloalkyl, halogen, nitro, amino, aryloxy, cyano, hydroxyl, or sulfonyl.
1. A compound, or a salt thereof, having the formula
wherein Y is
n is 1 or 2;
each R is independently H, alkyl, substituted alkyl, a polyether moiety, carboxyl, substituted carboxyl, carbamate, substituted carbonate, carbonyloxy, alkoxy, substituted alkoxy, haloalkyl, halogen, nitro, amino, aryloxy, cyano, hydroxyl, or sulfonyl;
R 1 is H, lower alkyl or aralkyl;
R 2 is selected from H, acyl, aralkyl, phosphonyl, —SO 2 R 3 ;
—C(O)R 5 ; —C(O)OR 7 or —C(O)NR 9 R 10 ;
R 3 ; R 5 ; R 7 ; R 9 and R 10 independently are selected from H, lower alkyl, aralkyl or aryl; and
R 20 is selected from alkyl, substituted alkyl, a polyether moiety, carboxyl, substituted carboxyl, carbamate, substituted carbonate, carbonyloxy, alkoxy, substituted alkoxy, haloalkyl, halogen, nitro, amino, aryloxy, cyano, hydroxyl, or sulfonyl.
2. A compound, or a salt thereof, having the formula
wherein Y is selected from
n is 1 or 2;
each R is independently H, alkyl, substituted alkyl, a polyether moiety, carboxyl, substituted carboxyl, carbamate, substituted carbonate, carbonyloxy, alkoxy, substituted alkoxy, haloalkyl, halogen, nitro, amino, aryloxy, cyano, hydroxyl, or sulfonyl;
R 1 is H, lower alkyl or aralkyl;
R 2 is selected from H, acyl, aralkyl, phosphonyl, —SO 2 R 3 ;
—C(O)R 5 ; —C(O)OR 7 or —C(O)NR 9 R 10 ;
R 3 ; R 5 ; R 7 ; R 9 and R 10 independently are selected from H, lower alkyl, aralkyl or aryl.
3. A compound, or a salt thereof, having the formula
wherein Y is
and
R is lower alkyl, substituted lower carboxyl, haloalkyl, or lower alkoxy; X is alkyl, substituted alkyl, a polyether moiety, carboxyl, substituted carboxyl, carbamate, substituted carbonate, carbonyloxy, alkoxy, substituted alkoxy, haloalkyl, halogen, nitro, amino, aryloxy, cyano, hydroxyl, or sulfonyl; and R 20 is selected from alkyl, substituted alkyl, a polyether moiety, carboxyl, substituted carboxyl, carbamate, substituted carbonate, carbonyloxy, alkoxy, substituted alkoxy, haloalkyl, halogen, nitro, amino, aryloxy, cyano, hydroxyl, or sulfonyl.
4. The compound of claim 3 , wherein X is a polyether moiety, a lower alkoxy, a lower alkyl, or halogen.
5. A compound, or a salt thereof, having the formula
wherein Y is
R is lower alkyl, substituted lower carboxyl, haloalkyl, or lower alkoxy; and X is alkyl, substituted alkyl, a polyether moiety, carboxyl, substituted carboxyl, carbamate, substituted carbonate, carbonyloxy, alkoxy, substituted alkoxy, haloalkyl, halogen, nitro, amino, aryloxy, cyano, hydroxyl, or sulfonyl.
6. The compound of claim 5 , wherein X is a polyether moiety, a lower alkoxy, a lower alkyl, or halogen.
7. A compound, or a salt thereof, having the formula
wherein Y represents an optionally substituted aromatic group;
each R is —COOR″ wherein R″ is a lower alkyl; and
X is alkyl, substituted alkyl, a polyether moiety, carboxyl, substituted carboxyl, carbamate, substituted carbonate, carbonyloxy, alkoxy, substituted alkoxy, haloalkyl, halogen, nitro, amino, aryloxy, cyano, hydroxyl, or sulfonyl.
8. The compound of claim 7 , wherein Y is
9. A compound, or a salt thereof, having the formula
wherein Y represents an optionally substituted aromatic group;
each R 15 is independently H, alkyl, substituted alkyl, a polyether moiety, carboxyl, substituted carboxyl, carbamate, substituted carbonate, carbonyloxy, alkoxy, substituted alkoxy, haloalkyl, halogen, nitro, amino, aryloxy, cyano, hydroxyl, or sulfonyl;
each X is independently halogen; and
m is 5.
10. A compound, or a salt thereof, having the formula
wherein Y represents an optionally substituted aromatic group;
each R 15 is independently H, alkyl, substituted alkyl, a polyether moiety, carboxyl, substituted carboxyl, carbamate, substituted carbonate, carbonyloxy, alkoxy, substituted alkoxy, haloalkyl, halogen, nitro, amino, aryloxy, cyano, hydroxyl, or;
X is a poly(ethylene oxide) moiety; and
m is 1 to 5.
11. The compound of claim 10 , wherein m is 1.
12. The compound of claim 1 , wherein R 20 is lower alkyl, nitro, amino, or lower alkoxy.
13. The compound of claim 3 , wherein R 20 is lower alkyl, nitro, amino, or lower alkoxy.
14. The compound of claim 2 , wherein R 1 is H and R 2 is —C(O)NR 9 R 10 .
15. The compound of claim 14 , wherein R 10 is a phenyl substituted with a polyether moiety, a lower alkoxy, or a lower alkyl.
16. A compound, or a salt thereof, having the formula
wherein Y represents an optionally substituted aromatic group;
each R is a lower alkyl, X is a para position relative to the position of the —NHC(O)NH— moiety, and X is a polyether moiety.