COMBINATION THERAPY USING A RUTHENIUM COMPLEX
A combination therapy is disclosed for treating cancer. The method comprises administering to a cancer patient a therapeutically effective amount of trans-[tetrachlorobis(1H-indazole)ruthenate(III)] or a pharmaceutically acceptable salt thereof, and administering to the patient a therapeutically effective amount of one or more other anti-cancer agents as disclosed herein.
1 . A method of treating cancer, comprising:
administering to a patient in need of treatment, simultaneously or sequentially (1) a pharmaceutically acceptable salt of trans-[tetrachlorobis(1H-indazole)ruthenate(III)], and (2) one or more anti-cancer agents chosen from the group consisting of platinum agents, taxane, anthracyclines, 5-FU and prodrugs thereof, nitrosourea compounds, gemcitabine, temozolomide, EGFR inhibitors, mTOR inhibitors, sorafenib, regorafenib, and sunitinib.
2 . The method of claim 1 , wherein said pharmaceutically acceptable salt of trans-[tetrachlorobis(1H-indazole)ruthenate(III)] is sodium trans-[tetrachlorobis(1H-indazole)ruthenate(III)].
3 . The method of claim 2 , wherein said one or more anti-cancer agents includes a platinum agent.
4 . The method of claim 3 , wherein said platinum agent is cisplatin, carboplatin, or oxaliplatin.
5 . The method of claim 2 , wherein said one or more anti-cancer agents includes an anthracycline.
6 . The method of claim 5 , wherein said anthracycline is doxorubicin.
7 . The method of claim 2 , wherein said one or more anti-cancer agents includes 5-FU or a prodrug thereof.
8 . The method of claim 2 , wherein said one or more anti-cancer agents includes a nitrosourea compound.
9 . The method of claim 8 , wherein said nitrosourea compound is BCNU.
10 . The method of claim 2 , wherein said one or more anti-cancer agents includes gemcitabine.
11 . The method of claim 2 , wherein said one or more anti-cancer agents includes temozolomide.
12 . The method of claim 2 , wherein said one or more anti-cancer agents includes an EGFR inhibitor.
13 . The method of claim 12 , wherein said EGFR inhibitor is erlotinib.
14 . The method of claim 2 , wherein said one or more anti-cancer agents includes an mTOR inhibitor.
15 . The method of claim 14 , wherein said mTOR inhibitor is everolimus.
16 . The method of claim 2 , wherein said one or more anti-cancer agents includes sorafenib or regorafenib.
17 . The method of claim 2 , wherein said one or more anti-cancer agents includes sunitinib.
18 . The method of claim 2 , wherein said one or more anti-cancer agents includes a taxane.
19 . The method of claim 18 , wherein said taxane is docetaxel or paclitaxel.
20 . A kit, comprising in a compartmentalized container:
a first unit dosage form of a pharmaceutically acceptable salt of trans-[tetrachlorobis(1H-indazole)ruthenate(III)]; and
a second unit dosage form of one anti-cancer agent chosen from the group consisting of platinum agents, taxane,anthracyclines, 5-FU and prodrugs thereof, nitrosourea compounds, gemcitabine, temozolomide, EGFR inhibitors, mTOR inhibitors, sorafenib, regorafenib, and sunitinib.