5,8-dihydro-6
The present invention encompasses compounds of general formula (I) wherein the groups R 1 to R 6 , A, B, C, n, p, q and r are defined as in claim 1 , which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, pharmaceutical preparations which contain compounds of this kind and their use as medicaments.
1. A compound of the formula (I)
wherein
R 1 denotes C 1-4 alkyl;
R 2 denotes hydrogen or C 1-4 alkyl;
R 3 denotes hydrogen or C 1-4 alkyl;
n denotes 0 or 1;
ring A is phenyl or 5-6 membered heteroaryl;
each R 4 is independently of one another selected from among halogen, C 1-4 alkoxy, C 1-4 alkyl and —CN;
p denotes 0, 1 or 2;
ring B is a 5-membered heteroaryl;
each R 5 independently is R b1 or a group, optionally substituted by one or more, identical or different R b1 and/or R c1 , selected from among C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 3-6 cycloalkyl, C 4-6 cycloalkenyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R b1 is independently selected from among —OR c1 , —NR c1 R c1 , halogen, —CN, —C(O)R c1 , —C(O)OR c1 , —C(O)NR c1 R c1 , —S(O) 2 R c1 , S(O) 2 NR c1 R c1 , —NHC(O)R c1 and —N(C 1-4 alkyl)C(O)R c1 ;
each R c1 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different R d1 and/or R e1 , selected from among C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 3-6 cycloalkyl, C 4-6 cycloalkenyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R d1 is independently selected from among —OR e1 , —NR e1 R e1 halogen, —CN, —C(O)R e1 , —C(O)OR e1 , —C(O)NR e1 R e1 , —S(O) 2 R e1 , —S(O) 2 NR e1 R e1 , — NHC(O)R e1 and —N(C 1-4 alkyl)C(O)R e1 ;
each R e1 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different R f1 and/or R g1 , selected from among C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 3-6 cycloalkyl, C 4-6 cycloalkenyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R f1 is independently selected from among —OR g1 , —NR g1 R g1 , halogen, —CN, —C(O)R g1 , —C(O)OR g1 , —C(O)NR g1 R g1 , —S(O) 2 R g1 , —S(O) 2 NR g1 R g1 , — NHC(O)R g1 and —N(C 1-4 alkyl)C(O)R g1 ;
each R g1 independently of one another denotes hydrogen or C 1-6 alkyl;
q denotes 0, 1 or 2;
ring C is phenyl or 5-6 membered heteroaryl;
each R 6 independently is R b2 or a group, optionally substituted by one or more, identical or different R b2 and/or R c2 , selected from among C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 3-6 cycloalkyl, C 4-6 cycloalkenyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R b2 is independently selected from among —OR c2 , —NR c2 R c2 , halogen, —CN, —C(O)R c2 , —C(O)OR c2 , —C(O)NR c2 R c2 , —S(O) 2 R c2 , —S(O) 2 NR c2 R c2 , — NHC(O)R c2 and —N(C 1-4 alkyl)C(O)R c2 ;
each R c2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different R d2 and/or R e2 , selected from among C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 3-6 cycloalkyl, C 4-6 cycloalkenyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R d2 is independently selected from among —OR e2 , —NR e2 R e2 , halogen, —CN, —C(O)R e2 , —C(O)OR e2 , —C(O)NR e2 R e2 , —S(O) 2 R e2 , —S(O) 2 NR e2 R e2 , — NHC(O)R e2 and —N(C 1-4 alkyl)C(O)R e2 ;
each R e2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different R f2 and/or R g2 , selected from among C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 3-6 cycloalkyl, C 4-6 cycloalkenyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R f2 is independently selected from among —OR g2 , —NR g2 R g2 , halogen, —CN, —C(O)R g2 , —C(O)OR g2 , —C(O)NR g2 R g2 , —S(O) 2 R g2 , —S(O) 2 NR g2 R g2 , — NHC(O)R g2 and —N(C 1-4 alkyl)C(O)R g2 ;
each R g2 independently of one another denotes hydrogen or C 1-6 alkyl;
r denotes 0, 1 or 2;
or a tautomer or salt thereof.
2. A compound according to claim 1 , wherein
ring C is phenyl;
each R 6 independently is R b2 or a group, optionally substituted by one or more, identical or different R b2 and/or R c2 , selected from among C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 3-6 cycloalkyl, C 4-6 cycloalkenyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R b2 is independently selected from among —OR c2 , —NR c2 R c2 , halogen, —CN, —C(O)R c2 , —C(O)OR c2 , —C(O)NR c2 R c2 , —S(O) 2 R c2 , —S(O) 2 NR c2 R c2 , — NHC(O)R c2 and —N(C 1-4 alkyl)C(O)R c2 ;
each R c2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different R d2 and/or R e2 , selected from among C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 3-6 cycloalkyl, C 4-6 cycloalkenyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R d2 is independently selected from among —OR e2 , —NR e2 R e2 , halogen, —CN, —C(O)R e2 , —C(O)OR e2 , —C(O)NR e2 R e2 , —S(O) 2 R e2 , —S(O) 2 NR e2 R e2 , — NHC(O)R e2 and —N(C 1-4 alkyl)C(O)R e2 ;
each R e2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different R f2 and/or R g2 , selected from among C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 3-6 cycloalkyl, C 4-6 cycloalkenyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R f2 is independently selected from among —OR g2 , —NR g2 R g2 , halogen, —CN, —C(O)R g2 , —C(O)OR g2 , —C(O)NR g2 R g2 , —S(O) 2 R g2 , —S(O) 2 NR g2 R g2 , — NHC(O)R g2 and —N(C 1-4 alkyl)C(O)R g2 ;
each R g2 independently of one another denotes hydrogen or C 1-6 alkyl;
r denotes 0, 1 or 2.
3. A compound according to claim 1 , wherein
ring C is phenyl;
each R 6 independently is R b2 or a group, optionally substituted by one or more, identical or different R b2 and/or R c2 , selected from among C 1-6 alkyl, C 3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R b2 is independently selected from among —OR c2 , —NR c2 R c2 , halogen, —CN, —C(O)R c2 , —C(O)OR c2 , —C(O)NR c2 R c2 , —S(O) 2 R c2 , —S(O) 2 NR c2 R c2 , —NHC(O)R c2 and —N(C 1-4 alkyl)C(O)R c2 ;
each R c2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different R d2 and/or R e2 , selected from among C 1-6 alkyl, C 3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R d2 is independently selected from among —OR e2 , —NR e2 R e2 , halogen, —CN, —C(O)R e2 , —C(O)OR e2 , —C(O)NR e2 R e2 , —S(O) 2 R e2 , —S(O) 2 NR e2 R e2 , — NHC(O)R e2 and —N(C 1-4 alkyl)C(O)R e2 ;
each R e2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different R f2 and/or R g2 , selected from among C 1-6 alkyl, C 3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R f2 is independently selected from among —OR g2 , —NR g2 R g2 , halogen, —CN, —C(O)R g2 , —C(O)OR g2 , —C(O)NR g2 R g2 , —S(O) 2 R g2 , —S(O) 2 NR g2 R g2 , — NHC(O)R g2 and —N(C 1-4 alkyl)C(O)R g2 ;
each R g2 independently of one another denotes hydrogen or C 1-6 alkyl;
r denotes 0, 1 or 2.
4. A compound according to claim 1 , wherein
ring C is phenyl;
each R 6 independently is R b2 or 3-7 membered heterocyclyl, the heterocyclyl optionally substituted by one or more, identical or different R b2 and/or R c2 ;
each R b2 is independently selected from among —OR c2 , —C(O)R c2 , —C(O)OR c2 , —C(O)NR c2 R c2 and —S(O) 2 NR c2 R c2 ;
each R c2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different R d2 and/or R e2 , selected from among C 1-6 alkyl and 3-7 membered heterocyclyl;
each R d2 is independently selected from among —OR e2 and —NR e2 R e2 ;
each R e2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different R f2 and/or R g2 , selected from among C 1-6 alkyl and 3-7 membered heterocyclyl;
each R f2 is —OR g2 ;
each R g2 independently of one another denotes hydrogen or C 1-6 alkyl;
r denotes 0, 1 or 2.
5. A compound according to claim 1 , wherein
ring C is phenyl;
each R 6 independently is —C(O)NR c2 R c2 , —C(O)R c2 or —OR c2 ;
each R c2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different R d2 and/or R e2 , selected from among C 1-6 alkyl and 3-7 membered heterocyclyl;
each R d2 is independently selected from among —OR e2 and —NR e2 R e2 ;
each R e2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different R f2 and/or R g2 , selected from among C 1-6 alkyl and 3-7 membered heterocyclyl;
each R f2 is —OR g2 ;
each R g2 independently of one another denotes hydrogen or C 1-6 alkyl;
r denotes 0, 1 or 2.
6. A compound according to claim 1 , wherein
r is 2.
7. A compound according to claim 1 , wherein
ring C is 5-6 membered heteroaryl;
each R 6 independently is R b2 or a group, optionally substituted by one or more, identical or different R b2 and/or R c2 , selected from among C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 3-6 cycloalkyl, C 4-6 cycloalkenyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R b2 is independently selected from among —OR c2 , —NR c2 R c2 , halogen, —CN, —C(O)R c2 , —C(O)OR c2 , —C(O)NR c2 R c2 , —S(O) 2 R c2 , —S(O) 2 NR c2 R c2 , —NHC(O)R c2 and —N(C 1-4 alkyl)C(O)R c2 ;
each R c2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different R d2 and/or R e2 , selected from among C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 3-6 cycloalkyl, C 4-6 cycloalkenyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R d2 is independently selected from among —OR e2 , —NR e2 R e2 , halogen, —CN, —C(O)R e2 , —C(O)OR e2 , —C(O)NR e2 R e2 , —S(O) 2 R e2 , —S(O) 2 NR e2 R e2 , — NHC(O)R e2 and —N(C 1-4 alkyl)C(O)R e2 ;
each R e2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different R f2 and/or R g2 , selected from among C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 3-6 cycloalkyl, C 4-6 cycloalkenyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R f2 is independently selected from among —OR g2 , —NR g2 R g2 , halogen, —CN, —C(O)R g2 , —C(O)OR g2 , —C(O)NR g2 R g2 , —S(O) 2 R g2 , —S(O) 2 NR g2 R g2 , — NHC(O)R g2 and —N(C 1-4 alkyl)C(O)R g2 ;
each R g2 independently of one another denotes hydrogen or C 1-6 alkyl;
r denotes 0, 1 or 2.
8. A compound according to claim 7 , wherein
ring C is 5-6 membered heteroaryl;
each R 6 independently is R b2 or a group, optionally substituted by one or more, identical or different R b2 and/or R c2 , selected from among C 1-6 alkyl, C 3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R b2 is independently selected from among —OR c2 , —NR c2 R c2 , halogen, —CN, —C(O)R c2 , —C(O)OR c2 , —C(O)NR c2 R c2 , —S(O) 2 R c2 , —S(O) 2 NR c2 R c2 , —NHC(O)R c2 and —N(C 1-4 alkyl)C(O)R c2 ;
each R c2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different R d2 and/or R e2 , selected from among C 1-6 alkyl, C 3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R d2 is independently selected from among —OR e2 , —NR e2 R e2 , halogen, —CN, —C(O)R e2 , —C(O)OR e2 , —C(O)NR e2 R e2 , —S(O) 2 R e2 , —S(O) 2 NR e2 R e2 , — NHC(O)R e2 and —N(C 1-4 alkyl)C(O)R e2 ;
each R e2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different R f2 and/or R g2 , selected from among C 1-6 alkyl, C 3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R f2 is independently selected from among —OR g2 , —NR g2 R g2 , halogen, —CN, —C(O)R g2 , —C(O)OR g2 , —C(O)NR g2 R g2 , —S(O) 2 R g2 , —S(O) 2 NR g2 R g2 , — NHC(O)R g2 and —N(C 1-4 alkyl)C(O)R g2 ;
each R g2 independently of one another denotes hydrogen or C 1-6 alkyl;
r denotes 0, 1 or 2.
9. A compound according to claim 8 , wherein
ring C is pyrazolyl;
each R 6 independently is R b2 or a group, optionally substituted by one or more, identical or different R b2 and/or R c2 , selected from among C 1-6 alkyl, C 3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R b2 is independently selected from among —OR c2 , —NR c2 R c2 , halogen, —CN, —C(O)R c2 , —C(O)OR c2 , —C(O)NR c2 R c2 , —S(O) 2 R c2 , —S(O) 2 NR c2 R c2 , —NHC(O)R c2 and —N(C 1-4 alkyl)C(O)R c2 ;
each R c2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different R d2 and/or R e2 , selected from among C 1-6 alkyl, C 3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R d2 is independently selected from among —OR e2 , —NR e2 R e2 , halogen, —CN, —C(O)R e2 , —C(O)OR e2 , —C(O)NR e2 R e2 , —S(O) 2 R e2 , —S(O) 2 NR e2 R e2 , —NHC(O)R e2 and —N(C 1-4 alkyl)C(O)R e2 ;
each R e2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different R f2 and/or R g2 , selected from among C 1-6 alkyl, C 3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R f2 is independently selected from among —OR g2 , —NR g2 R g2 , halogen, —CN, —C(O)R g2 , —C(O)OR g2 , —C(O)NR g2 R g2 , —S(O) 2 R g2 , —S(O) 2 NR g2 R g2 , —NHC(O)R g2 and —N(C 1-4 alkyl)C(O)R g2 ;
each R g2 independently of one another denotes hydrogen or C 1-6 alkyl;
r denotes 0, 1 or 2.
10. A compound according to claim 9 , wherein
ring C is pyrazolyl;
each R 6 independently is a group, optionally substituted by one or more, identical or different R b2 and/or R c2 , selected from among C 1-6 alkyl and 3-7 membered heterocyclyl;
each R b2 is independently selected from among —OR c2 , —NR c2 R c2 , —C(O)R c2 , —C(O)OR c2 , —C(O)NR c2 R c2 , S(O) 2 R c2 and —S(O) 2 NR c2 R c2 ;
each R c2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different R d2 and/or R e2 , selected from among C 1-6 alkyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R d2 is independently selected from among —OR e2 and —NR e2 R e2 ;
each R e2 independently of one another denotes hydrogen or C 1-6 alkyl optionally substituted by one or more, identical or different R f2 and/or R g2 ;
each R f2 is —OR g2 ;
each R g2 independently of one another denotes hydrogen or C 1-6 alkyl;
r denotes 0, 1 or 2.
11. A compound according to claim 10 , wherein
r is 1.
12. A compound according to claim 10 , wherein
r is 1 and ring C and R 6 altogether is
R 6 independently is a group, optionally substituted by one or more, identical or different R b2 and/or R c2 , selected from among C 1-6 alkyl and 3-7 membered heterocyclyl;
each R b2 is independently selected from among —OR c2 , —NR c2 R c2 , —C(O)R c2 , —C(O)OR c2 , —C(O)NR c2 R c2 , —S(O) 2 R c2 and —S(O) 2 NR c2 R c2 ;
each R c2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different R d2 and/or R e2 , selected from among C 1-6 alkyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R d2 is independently selected from among —OR e2 and —NR e2 R e2 ;
each R e2 independently of one another denotes hydrogen or C 1-6 alkyl optionally substituted by one or more, identical or different R f2 and/or R g2 ;
each R f2 is —OR g2 ;
each R g2 independently of one another denotes hydrogen or C 1-6 alkyl.
13. A compound according to claim 12 , wherein
r is 1 and ring C and R 6 altogether is
R 6 independently is selected from among C 1-4 alkyl, hydroxy-C 2-4 alkyl, C 1-4 alkoxy-C 2-4 alkyl and (C 1-4 alkyl) 2 N—C 2-4 alkyl.
14. A compound according to claim 12 , wherein
r is 1 and ring C and R 6 altogether is selected from among
15. A compound according to claim 1 , wherein
ring B is a 5-membered heteroaryl;
each R 5 independently is R b1 or a group, optionally substituted by one or more, identical or different R b1 and/or R c1 , selected from among C 1-6 alkyl, C 3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R b1 is independently selected from among —OR c1 , —NR c1 R c1 , halogen, —CN, —C(O)R c1 , —C(O)OR c1 , —C(O)NR c1 R c1 , —S(O) 2 R c1 , —S(O) 2 NR c1 R c1 , —NHC(O)R c1 and —N(C 1-4 alkyl)C(O)R c1 ;
each R c1 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different R d1 and/or R e1 , selected from among C 1-6 alkyl, C 3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R d1 is independently selected from among —OR e1 , —NR e1 R e1 , halogen, —CN, —C(O)R e1 , —C(O)OR e1 , —C(O)NR e1 R e1 , —S(O) 2 R e1 , —S(O) 2 NR e1 R e1 , —NHC(O)R e1 and —N(C 1-4 alkyl)C(O)R e1 ;
each R e1 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different R f1 and/or R g1 , selected from among C 1-6 alkyl, C 3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R f1 is independently selected from among —OR g1 , —NR g1 R g1 , halogen, —CN, —C(O)R g1 , —C(O)OR g1 , —C(O)NR g1 R g1 , —S(O) 2 R g1 , —S(O) 2 NR g1 R g1 , —NHC(O)R g1 and —N(C 1-4 alkyl)C(O)R g1 ;
each R g1 independently of one another denotes hydrogen or C 1-6 alkyl;
q denotes 0, 1 or 2.
16. A compound according to claim 15 , wherein
ring B is pyrazolyl;
each R 5 independently is R b1 or a group, optionally substituted by one or more, identical or different R b1 and/or R c1 , selected from among C 1-6 alkyl, C 3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R b1 is independently selected from among —OR c1 , —NR c1 R c1 , halogen, —CN, —C(O)R c1 , —C(O)OR c1 , —C(O)NR c1 R c1 , —S(O) 2 R c1 , —S(O) 2 NR c1 R c1 , —NHC(O)R c1 and —N(C 1-4 alkyl)C(O)R c1 ;
each R c1 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different R d1 and/or R e1 , selected from among C 1-6 alkyl, C 3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R d1 is independently selected from among —OR e1 , —NR e1 R e1 , halogen, —CN, —C(O)R e1 , —C(O)OR e1 , —C(O)NR e1 R e1 , —S(O) 2 R e1 , —S(O) 2 NR e1 R e1 , —NHC(O)R e1 and —N(C 1-4 alkyl)C(O)R e1 ;
each R e1 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different R f1 and/or R g1 , selected from among C 1-6 alkyl, C 3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each R f1 is independently selected from among —OR g1 , —NR g1 R g1 , halogen, —CN, —C(O)R g1 , —C(O)OR g1 , —C(O)NR g1 R g1 , —S(O) 2 R g1 , —S(O) 2 NR g1 R g1 , —NHC(O)R g1 and —N(C 1-4 alkyl)C(O)R g1 ;
each R g1 independently of one another denotes hydrogen or C 1-6 alkyl;
q denotes 0, 1 or 2.
17. A compound according to claim 16 , wherein
ring B is pyrazolyl;
each R 5 independently is a group, optionally substituted by one or more, identical or different R b1 and/or R c1 , selected from among C 1-6 alkyl and 3-7 membered heterocyclyl;
each R b1 is independently selected from among —OR c1 , —NR c1 R c1 , halogen, —C(O)OR c1 and —C(O)NR c1 R c1 ;
each R c1 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different R d1 and/or R e1 , selected from among C 1-6 alkyl, phenyl and 3-7 membered heterocyclyl;
each R d1 is independently selected from among —OR e1 and —NR e1 R e1 ;
each R e1 independently of one another denotes hydrogen or C 1-6 alkyl optionally substituted by one or more, identical or different R f1 and/or R g1 ;
each R f1 is —OR g1 ;
each R g1 independently of one another denotes hydrogen or C 1-6 alkyl;
q denotes 0, 1 or 2.
18. A compound according to claim 17 , wherein
q is 1.
19. A compound according to claim 17 , wherein
q is 1 and ring B and R 5 altogether is
R 5 is a group, optionally substituted by one or more, identical or different R b1 and/or R c1 , selected from among C 1-6 alkyl and 3-7 membered heterocyclyl;
each R b1 is independently selected from among —OR c1 , —NR c1 R c1 , halogen, —C(O)OR c1 and —C(O)NR c1 R c1 ;
each R c1 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different R d1 and/or R e1 , selected from among C 1-6 alkyl, phenyl and 3-7 membered heterocyclyl;
each R d1 is independently selected from among —OR e1 and —NR e1 R e1 ;
each R e1 independently of one another denotes hydrogen or C 1-6 alkyl optionally substituted by one or more, identical or different R f1 and/or R g1 ;
each R f1 is —OR g1 ;
each R g1 independently of one another denotes hydrogen or C 1-6 alkyl.
20. A compound according to claim 19 , wherein
q is 1 and ring B and R 5 altogether is
R 5 independently is selected from among C 1-4 alkyl, hydroxy-C 2-4 alkyl, C 1-4 alkoxy-C 2-4 alkyl and (C 1-4 alkyl) 2 N—C 2-4 alkyl.
21. A compound according to claim 19 , wherein
q is 1 and ring B and R 5 altogether is selected from among
22. A compound according to claim 1 , wherein
R 1 is methyl.
23. A compound according to claim 1 , wherein
R 2 and R 3 both denote hydrogen.
24. A compound according to claim 1 , wherein
R 2 is hydrogen and R 3 is C 1-4 alkyl.
25. A compound according to claim 1 , wherein
R 2 is hydrogen and R 3 is methyl.
26. A compound according to claim 1 , wherein
ring A is phenyl or pyridyl;
each R 4 is independently of one another selected from among halogen, C 1-4 alkoxy, C 1-4 alkyl and —CN;
p denotes 0, 1 or 2.
27. A compound according claim 26 , wherein
ring A is phenyl or pyridyl;
p is 0.
28. A compound according to claim 1 selected from the group consisting of
or a tautomer or salt thereof.
29. A pharmaceutically acceptable salt of a compound according to one of claim 1 to 28 .
30. A pharmaceutical preparation containing as active substance a compound of formula (I) according to claim 1 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient or carrier.