Devices, systems, and methods to compensate for effects of temperature on implantable sensors

1. A method for determining an estimated glucose value using a transcutaneous glucose sensor, the method comprising:

receiving sensor data from the transcutaneous glucose sensor, wherein the transcutaneous glucose sensor comprises an in vivo portion and an ex vivo portion, wherein the in vivo portion comprises an electrode and a membrane covering the electrode, wherein the membrane comprises an enzyme configured to catalyze a reaction involving glucose, wherein reaction kinetics of the enzyme are affected by temperature changes, wherein the transcutaneous glucose sensor has a sensitivity to glucose that is changed by a temperature change's effect on a permeability of glucose diffusing from interstitial fluid through at least a portion of the membrane or by the temperature change's effect on an enzymatic activity of the enzyme, wherein the sensor data comprise at least one sensor data point corresponding to a first time period, the first time period being after a sensor run-in period for the transcutaneous glucose sensor, wherein the at least one sensor data point is representative of a glucose concentration in a host for the first time period;

determining, using a temperature sensor, a temperature associated with the in vivo portion of the transcutaneous glucose sensor;

generating the estimated glucose value, using sensor electronics and the at least one sensor data point, the generating responsive to the temperature associated with the transcutaneous glucose sensor, wherein the generating comprises applying: (i) a temperature compensation associated with a relationship between the sensitivity of the transcutaneous glucose sensor to glucose as a function of temperature, the relationship describing the transcutaneous glucose sensor after the sensor run-in period, and (ii) a drift compensation associated with a change in sensitivity over time; and

displaying the estimated glucose value on a user interface.

2. The method of claim 1 , wherein determining the temperature comprises measuring a temperature associated with the in vivo portion of the transcutaneous glucose sensor.

3. The method of claim 1 , wherein determining the temperature comprises measuring a change in temperature.

4. The method of claim 1 , wherein generating the estimated glucose value comprises adjusting the sensor data for the first time period to compensate for an effect of the temperature on the transcutaneous glucose sensor.

5. The method of claim 1 , further comprising:

receiving, from an in vitro reference glucose sensor, a reference data point corresponding to a second time period; and

wherein processing, using sensor electronics, the at least one sensor data point comprises adjusting the sensor data to compensate for a change in temperature between the first time period and the second time period.

6. The method of claim 1 , wherein processing, using sensor electronics, the at least one sensor data point comprises:

determining a sensitivity value of the transcutaneous glucose sensor;

forming a conversion function based at least in part on the sensitivity value; and

determining a glucose output value by applying the conversion function to the at least one sensor data point.

7. The method of claim 6 , further comprising adjusting the sensitivity value responsive to the determined temperature.

8. The method of claim 6 , wherein determining the sensitivity value is performed by applying a priori sensitivity information comprising sensor sensitivity information as a function of temperature.

9. The method of claim 8 , wherein the a priori sensitivity information is stored in the sensor electronics prior to use of the transcutaneous glucose sensor.