PHOSPHOLIPID AND PROTEIN TABLETS
A new method for krill meal production has been developed using a two step cooking process. In the first step the proteins and phospholipids are removed from the krill and precipitated as a coagulum. In the second stage the krill without phospholipids are cooked. Following this, residual fat and astaxanthin are removed from the krill using mechanical separation methods. A novel krill meal product with superior nutritional and technical properties is prepared.
1 . A solid dosage form comprising an active ingredient in a concentration of greater than about 40% by weight of said dosage form, wherein said active ingredient is a protein-phospholipid composition comprising protein in a concentration of about 30% to about 50% by weight of said active ingredient and fat in a concentration of about 50% to about 75% by weight of said active ingredient, wherein said fat comprises phospholipids in a concentration of about 35% to about 60% by weight of said fat; and an adsorption agent; wherein said dosage form has a hardness of greater than about 60 N.
2 . The solid dosage form of claim 1 , wherein said protein-phospholipid composition is derived from krill.
3 . The solid dosage form of claim 1 , wherein said active ingredient further comprises astaxanthin.
4 . The solid dosage form of claim 3 , wherein said active ingredient comprises from about 1 to about 200 mg/kg astaxanthin
5 . The solid dosage form of claim 1 , wherein said fat comprises omega-3 fatty acids residues in a concentration of from about 10% to about 35% by weight of said fat.
6 . The solid dosage form of claim 1 , wherein said phospholipids comprise phosphatidylcholine in a concentration of greater than about 65% by weight of said phospholipids.
7 . The solid dosage form of claim 1 , wherein said phospholipids comprise alkylacylphosphatidylcholine in a concentration of from about 2% to about 10% by weight of said phospholipids.
8 . The solid dosage form of claim 1 , said adsorption agent is provided in a concentration of from about 18% to about 25% by weight of said dosage form.
9 . The solid dosage form of claim 1 , further comprising a binding agent in a concentration of from about 8% to about 15% by weight of said dosage form.
10 . The solid dosage form of claim 1 , further comprising a disintegrant in a concentration of from about 2% to about 8% by weight of said dosage form.
11 . The solid dosage form of claim 1 , wherein said solid dosage form comprises omega-3 fatty residues in a concentration of about 2.5% to 15% by weight of said dosage form.
12 . The solid dosage form of claim 1 , wherein said fat comprises triglycerides in a concentration of from about 40% to about 65% by weight of said fat.
13 . The solid dosage form of claim 1 , wherein said protein comprises from about 8% to about 14% leucine by weight of said protein.
14 . The solid dosage form of claim 1 , wherein the dissolution of the dosage form in a medium containing demineralized water as a solvent is greater than 75 percent at about 10 minutes where the tablet is raised and lowered in said solvent at a constant frequency rate between 29 and 32 cycles per minute, through a distance of 55±2 mm.
15 . The solid dosage form of claim 1 , wherein said dosage form is a tablet.
16 . A solid dosage form comprising an active ingredient in a concentration of about 55% to about 65% by weight of said dosage form, wherein said active ingredient is a protein-phospholipid composition comprising protein in a concentration of about 30% to about 50% by weight of said active ingredient and fat in a concentration of about 50% to about 75% by weight of said active ingredient, wherein said fat comprises phospholipids in a concentration of about 35% to about 60% by weight of said fat; an adsorption agent in a concentration of about 18% to about 25% by weight of said dosage form, a binding agent in a concentration of about 8% to about 15% by weight of said dosage form; wherein said dosage form has a hardness of greater than about 60 N.
17 . A process for the preparation of the solid dosage form of claim 1 comprising:
wet granulating an inner phase comprising an active ingredient, wherein said active ingredient is a protein-phospholipid composition comprising protein in a concentration of about 30% to about 50% by weight of said active ingredient and fat in a concentration of about 50% to about 75% by weight of said active ingredient, wherein said fat comprises phospholipids in a concentration of about 35% to about 60% by weight of said fat, and one or more pharmaceutically acceptable excipients;
forming an outer phase comprising one or more pharmaceutically acceptable excipients;
mixing said outer phase with said inner phase to form a compressible mixture; and
compressing said compressible mixture to form a tablet.