Nanoparticle-textured surfaces and related methods for selective adhesion, sensing and separation
The present invention includes an article of manufacture or device, or related system, comprising a heterogeneous surface for selective analyte sensing or separation. Such an article can comprise a surface member and a plurality of spaced components extending therefrom and coupled thereto, such a surface member and spaced components providing a surface heterogeneity selected from different electrostatic interactions, different non-electrostatic interactions and a combination of such interactions, such that the interactions are at least partially sufficient for selective analyte interaction and/or separation. Each such component extension can be of a nanometer dimension about the Debye length of a medium comprising an analyte particle exposed to such a surface. An analyte particle, optionally of a mixture of particles, can be dimensioned from about 30 nm to 20 μm. In some embodiments, the extended components have a density at least partially sufficient for interaction of a single such component or multiple components with a single analyte particle, at a given Debye length. In other embodiments, such components have an average spatial density at least partially sufficient for selective particle interaction and/or separation.
1. A heterogeneous surface article for selective analyte separation or interaction, said article comprising a surface member and a plurality of components coupled thereto and extending therefrom, said components spaced about said surface member and having a density thereon, said surface member and said spaced components providing a surface heterogeneity selected from different electrostatic interactions, different non-electrostatic interactions and a combination of said interactions, said interactions at least partially sufficient for at least one of selective analyte interaction and selective analyte separation, the component extensions of nanometer dimension about the Debye length of a medium comprising an analyte particle exposed to said article, said analyte particle dimensioned from about 30 nm to about 20 μm.
2. The article of claim 1 wherein the spatial density is at least partially sufficient for interaction of at least one said component with a single analyte particle, at a given particle Debye length.
3. The article of claim 2 wherein said spatial density is varied for selective particle interaction.
4. The article of claim 2 wherein said components extend up to about 50 nanometers from said surface member.
5. The article of claim 4 wherein a said component comprises a nanoparticulate composition comprising a metal core and a shell thereabout, the component dimension comprising the core/shell diameter.
6. The article of claim 5 wherein said core comprises a precious metal and said shell comprises ligands selected from cationic and anionic ligands.
7. The article of claim 6 wherein said nanoparticulate composition comprises cationic ligands, said component comprising a net positive charge, and said surface member comprising a net negative charge.
8. The article of claim 7 wherein a said component comprises ligands functionalized with quaternary ammonium salts, and said surface member comprises silica.