Synthesis of triethylenetetramines
Methods and intermediates for synthesizing triethylenetetramine and salts thereof, as well as novel triethylenetetramine salts and their crystal structure, and triethylenetetramine salts of high purity.
1. An isolated triethylenetetramine hydrochloride salt that has a purity of greater than about 95% pure.
2. The isolated triethylenetetramine hydrochloride salt of claim 1 wherein the salt is a triethylenetetramine dihydrochloride salt.
3. The isolated triethylenetetramine hydrochloride salt of claim 1 that has a purity of greater than about 96% pure.
4. The isolated triethylenetetramine hydrochloride salt of claim 3 wherein the salt is a triethylenetetramine dihydrochloride salt.
5. The isolated triethylenetetramine hydrochloride salt of claim 1 that has a purity of greater than about 97% pure.
6. The isolated triethylenetetramine hydrochloride salt of claim 5 wherein the salt is a triethylenetetramine dihydrochloride salt.
7. The isolated triethylenetetramine hydrochloride salt of claim 1 that has a purity of greater than about 98% pure.
8. The isolated triethylenetetramine hydrochloride salt of claim 7 wherein the salt is a triethylenetetramine dihydrochloride salt.
9. The isolated triethylenetetramine hydrochloride salt of claim 1 that has a purity of greater than about 99% pure.
10. The isolated triethylenetetramine hydrochloride salt of claim 9 wherein the salt is a triethylenetetramine dihydrochloride salt.
11. The isolated triethylenetetramine hydrochloride salt of claim 1 that has a purity of about 100% pure.
12. The isolated triethylenetetramine hydrochloride salt of claim 11 wherein the salt is a triethylenetetramine dihydrochloride salt.
13. A pharmaceutical composition comprising triethylenetetramine dihydrochloride having less than 5% impurities and a pharmaceutically acceptable excipient.
14. The pharmaceutical composition of claim 13 wherein the triethylenetetramine dihydrochloride has a purity of greater than about 95% pure.
15. An isolated triethylenetetramine salt that has a purity of greater than about 99% pure and has less than 10 ppm of heavy metals as determined by USP <231> II.