IP Library › Granted Patent US 8,592,371
Granted Patent B2
US 8,592,371 · App. 13/761,407 · Granted Nov 26, 2013

Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes

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Quick Facts
Patent No.
US 8,592,371
App. No.
13/761,407
Granted
Nov 26, 2013
Kind
B2
Abstract

The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

Claims (2)

1. A method of treating diabetes in a patient comprising administering to a patient in need thereof a therapeutically effective amount of a compound which is:

or a pharmaceutically acceptable salt in combination with insulin.

Assignments (1)
MERGER Recorded Aug 8, 2022
From: MERCK SHARP & DOHME CORP.
To: MERCK SHARP & DOHME LLC
Reel/Frame 061102/0145 →