Treating attention deficit hyperactivity disorder with NHE inhibitors
View Patent ↗The present invention relates to a method of treating attention deficit hyperactivity disorder in a subject. This method includes selecting a subject with attention deficit hyperactivity disorder and administering to the selected subject a sodium/hydrogen exchanger inhibitor under conditions effective to treat the subject for attention deficit hyperactivity disorder. Methods of identifying compounds suitable to treat attention deficit hyperactivity disorder are also disclosed.
1. A method of treating attention deficit hyperactivity disorder in a subject, said method comprising:
selecting a subject with attention deficit hyperactivity disorder and
administering to the selected subject a sodium/hydrogen exchanger inhibitor under conditions effective to treat the selected subject for attention deficit hyperactivity disorder, wherein the sodium/hydrogen exchange inhibitor is selected from a group consisting of cariporide, amiloride, s3226, and benzamil.
2. The method of claim 1 , wherein the selected subject is a human.
3. The method of claim 1 , wherein said administering is carried out parenterally, orally, subcutaneously, intravenously, intramuscularly, extraperitoneally, by intranasal instillation, by inhalation, or by application to mucous membranes.
4. The method of claim 1 , wherein the sodium/hydrogen exchanger inhibitor is administered in combination with a pharmaceutical carrier or diluent.