Conjugated TLR7 and/or TLR8 and TLR2 polycationic agonists

1. A conjugated compound of Formula I:

Q-Z—R 4   Formula I

wherein Q is

a tautomer thereof or a pharmaceutically acceptable salt, of said compound or tautomer, wherein:

R 2 is a C 1 -C 10 alkylamino;

Z—R 4 is a TLR2 agonist of formula III:

wherein:

R 5 is the specific side chain of L or D isomers of an amino acid selected from the group consisting of alanine, valine, leucine, isoleucine, phenylalanine, tryptophan, methionine, glycine, serine, threonine, cysteine, tyrosine, asparagine, glutamine, aspartic acid, glutamic acid, lysine, arginine, proline and histidine;

j and l, identical or different, are 0 or 1;

p is integer from 0 to 6;

m, n, o, and q, identical or different, are integers from 1 to 4;

and

R 4 is a lipid of Formula XI:

wherein:

R 7 and R 8 are independently from each other H, C 1 -C 30 alkyl, C 2 -C 30 lkylenyl, —C(O)—C 1 -C 30 alkyl, —C(O)—C 2 -C 30 alkylenyl, or —C(O)—O—C 1 -C 30 alkyl;

R 9 is H, C 1 -C 30 alkyl or C 2 -C 30 alkylenyl;

R 10 is H, C 1 -C 30 alkyl or C 2 -C 30 alkylenyl;

R 9 and R 10 are not both H;

L 1 is absent, —OC(O)—, —O—, —NR 11 C(O)—, —OC(O)NR 11 — or —CH2- wherein R 11 is H, C 1 -C 30 alkyl or C 2 -C 30 alkylenyl;

If L 1 is present, L 2 is —CH 2 OC(O)—, —CH 2 O—, —CH 2 NR 11 C(O)— or —CH 2 —, and if L 1 is absent, L 2 is —OC(O)—, —O—, —NR 11 C(O)—, —NR 10 R 11 , —OC(O)NR 11 — or —CH2- wherein R 11 is as defined above.

2. The conjugated compound according to claim 1 , wherein:

Z is of formula III wherein 1=1, R 5 ═H, m=3, n=4, p=1, o=3 and j=0 or 1 and q=2.

3. The conjugated compound according to claim 1 , wherein R 4 is a lipid of formula XI wherein:

R 7 and R 8 are independently from each other H or —C(O)—C 1 -C 30 alkyl;

R 9 and R 10 are independently from each other H or C 1 -C 30 alkyl;

R 9 and R 10 are not both H and

L 1 is absent and L 2 is —OC(O)—.

4. The conjugated compound according to claim 1 , wherein said conjugated compound is selected from the group consisting of:

(20R)-20-amino-1-(4-((6-amino-2-(butylamino)-8-hydroxy-9H-purin-9-yl)methyl)phenyl)-1,4,19-trioxo-22-thia-2,5,9,14,18-pentaazapentacosane-24,25-diyl dipalmitate,

(20R)-1-(4-((6-amino-2-(butylamino)-8-hydroxy-9H-purin-9-yl)methyl)phenyl)-1,4,19-trioxo-20-palmitamido-22-thia-2,5,9,14,18-pentaazapentacosane-24,25-diyl dipalmitate, and

(S)-methyl 1-(4-((6-amino-2-(butylamino)-8-hydroxy-9H-purin-9-yl)methyl)phenyl)-22-((R)-2-amino-3-(2-(tetradecanoyloxy)ethylthio)propanamido)-1,4,19-trioxo-2,5,9,14,18-pentaazatricosan-23-oate,

a tautomer thereof or a pharmaceutically acceptable salt of said compound or tautomer.