Device and methods for directing agents to the middle ear and the inner ear
This disclosure includes a method for pushing an active agent into a patient's ear via the device. The agent can be pushed to a treatment site.
1. A method for treating a patient comprising:
(a) providing a delivery device that generates an overall magnetic field, the device including a first magnet having a first magnetization and a first magnetic field, and a second magnet having a second magnetization and a second magnetic field, wherein the overall magnetic field is produced by the first and second magnetic fields overlapping to create a combined magnetic field and a node that is a local magnetic field strength minimum, the node being located away from the first and second magnets;
(b) placing the device proximal to a patient's ear;
(c) moving an agent into the patient's ear with the combined magnetic field; and
(d) pushing the agent towards a treatment site with the combined magnetic field.
2. The method as claimed in claim 1 , wherein the agent is magnetic, superparamagnetic, ferrimagnetic, ferromagnetic, or paramagnetic.
3. The method as claimed in claim 1 , wherein the agent is combined with a material that is magnetic, superparamagnetic, ferrimagnetic, ferromagnetic, or paramagnetic.
4. The method as claimed in claim 1 , wherein pushing the agent towards the treatment site further comprises pushing the agent away from the first and second magnets.
5. The method as claimed in claim 1 , wherein the treatment site is the patient's middle ear, and wherein pushing the agent towards the treatment site includes pushing an effective amount of the agent into the patient's middle ear with the combined magnetic field.
6. The method as claimed in claim 1 , wherein the treatment site is the patient's inner ear, and wherein pushing the agent towards the treatment site includes pushing an effective amount of the agent into the patient's inner ear with the combined magnetic field.
7. The method as claimed in claim 1 , wherein the agent is biodegradable.
8. The method as claimed in claim 1 , wherein the first and second magnets are arranged at an angle.
9. The method as claimed in claim 1 , wherein moving the agent into the patient's ear includes pushing the agent into a middle ear of the patient.
10. The method as claimed in claim 9 , wherein the treatment site is an inner ear of the patient, and wherein pushing the agent towards the treatment site includes pushing the agent from the middle ear to the inner ear of the patient.
11. A method to decrease inner ear or middle ear trauma in a subject while treating the subject comprising:
(a) placing a device, that generates an overall magnetic field, proximal to a subject's ear, the device including magnetic elements each having a magnetic field, the overall magnetic field is produced by the magnetic fields of the magnetic elements overlapping to create a combined field and a node that is a local magnetic field strength minimum, the node being located away from the magnetic elements; and
(b) pushing agents into the subject's ear with the overall magnetic field, wherein the tympanic membrane, oval window membrane or round window membrane is not materially punctured during treatment.
12. The method as claimed in claim 11 , wherein magnetic elements comprise at least two magnetic elements arranged at an angle.
13. The method as claimed in claim 11 , further comprising the step of placing the agents in the subject's ear canal.
14. The method as claimed in claim 11 , further comprising placing the agents within the subject's middle or outer ear.