IP Library › Granted Patent US 9,078,875
Granted Patent B2
US 9,078,875 · App. 13/780,601 · Granted Jul 14, 2015

LprG as a chaperone of immune adjuvants

Inventors: Clifford Harding (Shaker Heights, OH); W. Henry Boom (Shaker Heights, OH); Michael G. Drage (Cleveland Heights, OH); Nicole D. Pecora (Cleveland Heights, OH)
Assignee: Case Western Reserve University
A61K39/39A61K39/00A61K2039/55516A61K2039/55555
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Quick Facts
Patent No.
US 9,078,875
App. No.
13/780,601
Granted
Jul 14, 2015
Kind
B2
Abstract

An adjuvant combination that stimulates immune activation or response includes a hydrophobic immune adjuvant and a pathogen derived lipoprotein that chaperones the hydrophobic immune adjuvant to an immune receptor.

Claims (5)

1. An immune stimulating complex comprising:

a hydrophobic immune adjuvant and purified non-acylated or acylated Mycobacterium tuberculosis LprG lipoprotein, the non-acylated or acylated Mycobacterium tuberculosis LprG lipoprotein being present in an amount effective to chaperone the immune adjuvant to an immune receptor, the hydrophobic immune adjuvant being a glycolipid immune adjuvant.

2. The immune stimulating complex of claim 1 , the hydrophobic immune adjuvant being at least one of a TLR agonist or a TLR ligand.

3. The immune stimulating complex 1, the hydrophobic immune adjuvant being at least one of a TLR2 agonist or TLR4 agonist.

4. The immune stimulating complex of claim 1 , the glycolipid immune adjuvant comprising phosphatidylinositol.

Assignments (2)
CONFIRMATORY LICENSE Recorded Dec 8, 2016
From: CASE WESTERN RESERVE UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 040865/0959 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 9, 2014
From: HARDING, CLIFFORD V.; BOOM, WILLIAM HENRY; DRAGE, MICHAEL G.; PECORA, NICOLE D.
To: CASE WESTERN RESERVE UNIVERSITY
Reel/Frame 032858/0307 →
Continuity (3)
Continuation 12693896 · Jan 26, 2010
Provisional Application 61147304 · Jan 26, 2009
Related Publication 20140147468A1 · May 29, 2014