Methods and ceramic nanoparticle compositions for heavy metal removal and for oral delivery of desirable agents
Compositions and methods for heavy metal remediation are disclosed. The compositions contain ceramic nanoparticulate cation exchangers specific for at least one heavy metal as well as at least one carrier, typically a thickener, a gel forming agent and/or a cross-binding agent. The compositions may also contain chelating agents as well as beneficial agents such as vitamins and pharmaceuticals, with or without the ceramic nanoparticulate cation exchangers.
1. A composition that sorbs heavy metals which comprises a ceramic nanoparticulate cation exchanger for at least one heavy metal and at least one carrier Wherein said carrier forms a gel mass in aqueous medium, and is non-toxic.
2. The composition of claim 1 wherein said carrier comprises an additional sorbent for heavy metals.
3. The composition of claim 2 wherein said additional sorbent is activated charcoal, derivatized chitosan, a heavy metal-absorbing plant material, a fumed silica, a zeolite, bentonite or combinations thereof.
4. The composition of claim 1 wherein said carrier comprises an agent for improving the handling properties of the composition and/or the behavior of the composition in the digestive tract.
5. The composition of claim 4 wherein said agent is a cross-binding agent, fluid-removal agent/gel-forming agent and a thickening agent or mixtures thereof.
6. The composition of claim 1 which further contains a heavy metal chelator.
7. The composition of claim 1 which comprises 50% (w/w) ATS Adsorbent mercury selective cationic ion exchanger (Engelhard), 50% (w/w) N-[3-(methylthio)propyl]-chitosan (MTPC) and further contains food flavorings to produce a marinade, or
which is a gelatin capsule containing (25% w/w) ATS adsorbent, mercury selective cationic ion exchange (Engelhard), (25% w/w) activated Charcoal, 25% (w/w) Pharmasorb® attapulgite, colloidal (Engelhard), and (25% w/w) Azolla filiculoides , root extract, granular, dry powder bio-adsorbent, or
which is a gelatin capsule containing 50% (w/w) ATS Adsorbent, mercury selective cationic ion exchanger (Engelhard), 40% (w/w) N-[3-(methylthio)propyl]-chitosan (MTPC), and (10% w/w) M5 fumed silica (Cabot) pharmaceutical grade, or
which is a gelatin capsule containing 80% (w/w) ATS ceramic adsorbent, lead selective cationic ion exchanger (Engelhard), and 20% (w/w) activated charcoal, pharmaceutical grade, or
which is a gelatin capsule containing 80% (w/w) ARM 200, arsenic selective, ion exchange adsorbent (Engelhard), and 20% (w/w) activated charcoal, pharmaceutical grade, or
which is a gelatin capsule containing 80% (w/w) ARM 200 ceramic, arsenic selective, cationic ion exchange powder (Engelhard), and 20% (w/w) carboxymethylcellulose, pharmaceutical grade, or equivalent.
8. A composition for oral delivery of beneficial compounds by absorption into the body from the digestive system, which composition comprises a nanoparticulate silica-based scaffold having a surface area of at least 50 m 2 /g, at least one beneficial compound, a miscibility agent, and a carrier that forms a gel mass in aqueous media.
9. The composition of claim 8 , wherein the nanoparticulate silica scaffold has a surface area of at least 380 m 2 /g, and/or
wherein said scaffold has been treated with a mucoadhesive agent, and/or
wherein the miscibility agent is polyethylene glycol or polysorbate ester, and/or
wherein said carrier contains a thickening agent and/or a fluid removal/gel-forming agent.
10. The composition of claim 9 , wherein the thickening agent comprises starch copolymers or clays, and/or
wherein the fluid removal/gel-forming agent is a crosslinked polyamine or polyacrylamide.
11. The composition of claim 8 , wherein said beneficial compound is a vitamin, pharmaceutical, or chelating agent.
12. The composition of claim 8 , which further is enclosed in an enteric coating.
13. The composition of claim 1 , which is suitable for oral consumption, and wherein said carrier is delivered in aqueous medium.
14. The composition of claim 13 , wherein said carrier comprises an additional sorbent for heavy metals.
15. The composition of claim 14 , wherein said additional sorbent is activated charcoal, derivatized chitosan, a heavy metal-absorbing plant material, a fumed silica, a zeolite, bentonite or combinations thereof.
16. The composition of claim 13 , which further contains a heavy metal chelator.
17. The composition of claim 13 , which is 5% (w/w) ATS Adsorbent mercury selective cationic ion exchanger (Engelhard), 10% (w/w) ARM 200, arsenic selective, ion exchange adsorbent (Engelhard), (25% w/w) Azolla filiculoides , root, and 60% (w/w) of ZK406H, a natural clinoptilolite form of potassium aluminosilicate, (St. Cloud Mining Company), or
which is 50% (w/w) ATS Adsorbent, selective cationic ion exchanger (Engelhard), and 50% (w/w) ZK406H, a natural clinoptilolite form of potassium aluminosilicate, (St. Cloud Mining Company).