Tannin inhibitors of HIV
View Patent ↗The invention provides a method to prevent or treat HIV-infection with synthetic tannins, and pharmaceutical compositions comprising synthetic tannins.
1. A method for treating HIV infection comprising administering to a subject afflicted with HIV infection an effective anti-HIV amount of a compound of formula (I):
wherein R 1 , R 2 , and R 3 are individually H, (C 1 -C 4 )alkyl or galloyl (G), p is 0 or 1, m is 0 or 1, and n is 0 or 1, with the provisos that when n is 0 there is a single bond between C 2 and C 4 , and when p is 0, C 1 is CH 2 ; that when R 1 is H, R 2 and R 3 are not both G; and when R 1 is G, R 2 and R 3 are not both G or H or R 2 is not H.
2. The method of claim 1 wherein n is 1, m is 1, and p is 1.
3. The method of claim 2 wherein R 1 is CH 3 .
4. The method of claim 3 wherein R 2 and R 3 are G or H.
5. The method of claim 2 wherein R 1 is H and R 2 and R 3 are not both G.
6. The method of claim 5 wherein R 2 or R 3 is H.
7. The method of claim 6 wherein R 2 and R 3 are H.
8. The method of claim 2 wherein R 1 is H, R 2 is G and R 3 is H.
9. A method for treating HIV infection comprising administering to a subject afflicted with HIV infection an effective anti-HIV amount of a compound of formula (I):
wherein R 1 , R 2 , and R 3 are individually H, (C 1 -C 4 )alkyl or galloyl (G), p is 0 or 1, m is 0 or 1, and n is 0, wherein there is a single bond between C 2 and C 4 , and with the proviso when p is 0, C 1 is CH 7 .
10. The method of claim 9 wherein the moiety:
11. The method of claim 9 wherein R 1 or R 2 is CH 3 .
12. The method of claim 9 wherein R 1 and/or R 2 are G.
13. The method of claim 1 wherein n is 1, and m is 0.
14. The method of claim 13 wherein the moiety:
15. The method of claim 14 wherein R 2 and/or R 3 are G.
16. The method of claim 15 wherein R 2 or R 3 are CH 3 .