Methods for thermally-induced hepatic neuromodulation
According to some embodiments, a method of treating a subject having diabetes or symptoms associated with diabetes is provided. The method includes delivering a neuromodulation catheter within a vessel (e.g., hepatic artery) having surrounding nerves that innervate the liver (e.g., sympathetic nerves of the hepatic plexus). The method may also include modulating (e.g., disrupting, ablating, stimulating) the nerves by mechanical compression, energy delivery, or fluid delivery.
1. A method for thermally-induced hepatic neuromodulation to decrease blood glucose levels within a subject, comprising:
identifying a subject having a metabolic disorder,
inserting a radiofrequency (RF) ablation catheter into vasculature of said subject;
advancing the RF ablation catheter to a location within a common hepatic artery of the vasculature;
wherein the location is within the common hepatic artery between a branch of the celiac artery and a branch of the common hepatic artery; and
using the RF ablation catheter to intravascularly deliver a therapeutically effective amount of RF energy to an inner wall of the common hepatic artery to ablate one or more sympathetic nerves of a hepatic plexus, thereby decreasing blood glucose levels within the subject,
wherein the RF ablation catheter comprises two electrodes, and
wherein the RF ablation catheter is configured to maintain sufficient contact pressure of at least one of said electrodes against the inner wall of the common hepatic artery while the RF energy is being delivered,
wherein the RF energy is caused to be delivered to an anterior 180° arc of the inner wall of the common hepatic artery, thereby ablating sympathetic nerves without ablating parasympathetic nerves.
2. The method of claim 1 , wherein the ablation catheter comprises a balloon catheter configured to maintain the sufficient contact pressure of the at least one electrode against the inner wall of the common hepatic artery.
3. The method of claim 1 , wherein the ablation catheter comprises a steerable distal tip configured to maintain the sufficient contact pressure of the at least one electrode against the inner wall of the common hepatic artery.
4. The method of claim 1 , wherein the sufficient contact pressure is between about 5 g/mm 2 and about 100 g/mm 2 .
5. The method of claim 1 , wherein the sufficient contact pressure is between about 0.1 g/mm 2 and about 10 g/mm 2 .
6. The method of claim 1 , wherein the therapeutically effective amount of RF energy is in the range of between about 100 J and about 1 kJ.
7. The method of claim 1 , wherein the therapeutically effective amount of RF energy has a power level between about 0.1 W and about 10 W.
8. The method of claim 1 , wherein the RF energy has a power level between about 3 W and about 8 W.
9. The method of claim 1 , further comprising providing cooling to a portion of the common hepatic artery that is not being targeted by the RF energy.
10. A method for thermally-induced hepatic neuromodulation to decrease blood glucose levels within a subject, comprising:
delivering a radiofrequency (RF) ablation catheter to a vicinity of a hepatic plexus within a hepatic artery branch, the RF ablation catheter comprising two electrodes;
positioning at least one of the two electrodes in contact with an inner wall of the hepatic artery branch; and
disrupting neural communication of sympathetic nerves of the hepatic plexus surrounding the hepatic artery branch by applying an electrical signal to the at least one electrode, thereby causing thermal energy to be delivered by the at least one electrode to heat the inner wall of the hepatic artery branch,
wherein disrupting neural communication comprises permanently disabling neural communication of sympathetic nerves of the hepatic plexus.
11. The method of claim 10 , wherein the hepatic artery branch is the proper hepatic artery.
12. The method of claim 10 , wherein the hepatic artery branch is the common hepatic artery.
13. The method of claim 10 , further comprising providing cooling to a portion of the hepatic artery branch that is not being targeted by the energy.
14. The method of claim 10 , wherein the catheter is configured to maintain contact pressure against the inner wall of the hepatic artery branch.
15. The method of claim 14 , wherein the contact pressure is between about 5 g/mm 2 and about 100 g/mm 2 .
16. The method of claim 14 , wherein the contact pressure is between about 0.1 g/mm 2 and about 10 g/mm 2 .
17. The method of claim 10 , wherein the energy is in the range of between about 100 J and about 1 kJ.
18. The method of claim 10 , wherein the energy has a power level between about 0.1 W and about 10 W.
19. The method of claim 10 , wherein the energy has a power level between about 3 W and about 8 W.
20. A method for thermally-induced hepatic neuromodulation to decrease blood glucose levels within a subject, comprising:
delivering a radiofrequency (RF) ablation catheter to a vicinity of a hepatic plexus within a hepatic artery branch, the RF ablation catheter comprising two electrodes;
positioning at least one of the two electrodes in contact with an inner wall of the hepatic artery branch; and
disrupting neural communication of sympathetic nerves of the hepatic plexus surrounding the hepatic artery branch by applying an electrical signal to the at least one electrode, thereby causing thermal energy to be delivered by the at least one electrode to heat the inner wall of the hepatic artery branch,
wherein disrupting neural communication comprises temporarily inhibiting or reducing neural communication of sympathetic nerves of the hepatic plexus.
21. The method of claim 20 , wherein the hepatic artery branch is the proper hepatic artery.
22. The method of claim 20 , wherein the hepatic artery branch is the common hepatic artery.
23. The method of claim 20 , further comprising providing cooling to a portion of the hepatic artery branch that is not being targeted by the energy.
24. The method of claim 20 , wherein the catheter is configured to maintain contact pressure against the inner wall of the hepatic artery branch.
25. The method of claim 24 , wherein the contact pressure is between about 5 g/mm 2 and about 100 g/mm 2 .
26. The method of claim 24 , wherein the contact pressure is between about 0.1 g/mm 2 and about 10 g/mm 2 .
27. The method of claim 20 , wherein the energy is in the range of between about 100 J and about 1 kJ.
28. The method of claim 20 , wherein the energy has a power level between about 0.1 W and about 10 W.
29. The method of claim 20 , wherein the energy has a power level between about 3 W and about 8 W.
30. A method for thermally-induced hepatic neuromodulation to decrease blood glucose levels within a subject, comprising:
delivering a radiofrequency (RF) ablation catheter to a vicinity of a hepatic plexus within a hepatic artery branch, the RF ablation catheter comprising two electrodes;
positioning at least one of the two electrodes in contact with an inner wall of the hepatic artery branch;
disrupting neural communication of sympathetic nerves of the hepatic plexus surrounding the hepatic artery branch by applying an electrical signal to the at least one electrode, thereby causing thermal energy to be delivered by the at least one electrode to heat the inner wall of the hepatic artery branch; and
positioning the RF ablation catheter in the vicinity of the celiac plexus of the subject and disrupting neural communication of sympathetic nerves of the celiac plexus by causing RF energy to be emitted from the at least one electrode of the RF ablation catheter.
31. The method of claim 30 , wherein the hepatic artery branch is the proper hepatic artery.
32. The method of claim 30 , wherein the hepatic artery branch is the common hepatic artery.
33. The method of claim 30 , further comprising providing cooling to a portion of the hepatic artery branch that is not being targeted by the energy.
34. The method of claim 30 , wherein the catheter is configured to maintain contact pressure against the inner wall of the hepatic artery branch.
35. The method of claim 34 , wherein the contact pressure is between about 5 g/mm 2 and about 100 g/mm 2 .
36. The method of claim 34 , wherein the contact pressure is between about 0.1 g/mm 2 and about 10 g/mm 2 .
37. The method of claim 30 , wherein the energy is in the range of between about 100 J and about 1 kJ.
38. The method of claim 30 , wherein the energy has a power level between about 0.1 W and about 10 W.
39. A method for thermally-induced hepatic neuromodulation to decrease blood glucose levels within a subject, comprising:
delivering a neuromodulation catheter within a hepatic artery to a vicinity of a hepatic plexus of a subject; and
modulating nerves of the hepatic plexus by using said catheter to deliver energy to the hepatic plexus sufficient to modulate one or more nerves within the hepatic plexus to decrease at least one of blood glucose levels or triglyceride levels in said subject,
wherein modulating the nerves of the hepatic plexus comprises denervating sympathetic nerves of the hepatic plexus without denervating parasympathetic nerves of the hepatic plexus.
40. The method of claim 30 , wherein the energy has a power level between about 3 W and about 8 W.
41. The method of claim 39 , wherein the hepatic artery is the proper hepatic artery.
42. The method of claim 39 , wherein the hepatic artery is the common hepatic artery.
43. The method of claim 39 , further comprising providing cooling to a portion of the hepatic artery that is not being targeted by the energy.
44. The method of claim 39 , wherein the catheter is configured to maintain contact pressure against an inner wall of the hepatic artery.
45. The method of claim 44 , wherein the contact pressure is between about 5 g/mm 2 and about 100 g/mm 2 .
46. The method of claim 44 , wherein the contact pressure is between about 0.1 g/mm 2 and about 10 g/mm 2 .
47. The method of claim 39 , wherein the energy is in the range of between about 100 J and about 1 kJ.
48. The method of claim 39 , wherein the energy has a power level between about 0.1 W and about 10 W.
49. The method of claim 39 , wherein the energy has a power level between about 3 W and about 8 W.
50. A method for thermally-induced hepatic neuromodulation to decrease blood glucose levels within a subject, comprising:
delivering a neuromodulation catheter within a hepatic artery to a vicinity of a hepatic plexus of a subject; and
modulating nerves of the hepatic plexus by using said energy catheter to deliver energy to the hepatic plexus sufficient to modulate one or more nerves within the hepatic plexus to decrease at least one of blood glucose levels or triglyceride levels in said subject,
wherein modulating the nerves of the hepatic plexus comprises denervating sympathetic nerves of the hepatic plexus and stimulating parasympathetic nerves of the hepatic plexus.
51. The method of claim 50 , wherein the hepatic artery is the proper hepatic artery.
52. The method of claim 50 , wherein the hepatic artery is the common hepatic artery.
53. The method of claim 50 , further comprising providing cooling to a portion of the hepatic artery that is not being targeted by the energy.
54. The method of claim 50 , wherein the catheter is configured to maintain contact pressure against an inner wall of the hepatic artery.
55. The method of claim 54 , wherein the contact pressure is between about 5 g/mm 2 and about 100 g/mm 2 .
56. The method of claim 54 , wherein the contact pressure is between about 0.1 g/mm 2 and about 10 g/mm 2 .
57. The method of claim 50 , wherein the energy is in the range of between about 100 J and about 1 kJ.
58. The method of claim 50 , wherein the energy has a power level between about 0.1 W and about 10 W.
59. The method of claim 50 , wherein the energy has a power level between about 3 W and about 8 W.
60. A method for thermally-induced hepatic neuromodulation to decrease blood glucose levels within a subject, comprising:
delivering a neuromodulation catheter within a hepatic artery to a vicinity of a hepatic plexus of a subject; and
modulating nerves of the hepatic plexus by using said energy catheter to deliver energy to the hepatic plexus sufficient to modulate one or more nerves within the hepatic plexus to decrease at least one of blood glucose levels or triglyceride levels in said subject,
wherein the energy delivered comprises radiofrequency energy sufficient to denervate said one or more nerves.
61. The method of claim 60 , wherein the hepatic artery is the proper hepatic artery.
62. The method of claim 60 , wherein the hepatic artery is the common hepatic artery.
63. The method of claim 60 , further comprising providing cooling to a portion of the hepatic artery that is not being targeted by the energy.
64. The method of claim 60 , wherein the catheter is configured to maintain contact pressure against an inner wall of the hepatic artery.
65. The method of claim 64 , wherein the contact pressure is between about 5 g/mm 2 and about 100 g/mm 2 .
66. The method of claim 64 , wherein the contact pressure is between about 0.1 g/mm 2 and about 10 g/mm 2 .
67. The method of claim 60 , wherein the energy is in the range of between about 100 J and about 1 kJ.
68. The method of claim 60 , wherein the energy has a power level between about 0.1 W and about 10 W.
69. The method of claim 60 , wherein the energy has a power level between about 3 W and about 8 W.