Sphaeranthus indicus derived ingredients and their compositions for enhancing physical performance and energy levels
The invention discloses herbal ingredients derived from Sphaeranthus indicus standardized to at least one frullanolide/eudesmanoid sesquiterpene compound and their compositions as natural energy enhancer to provide an onset and steady maintenance of energy and mental alertness in a mammal. The invention further includes the use of ingredients and compositions for food ingredient formulations such as dietary supplement, food ingredient, beverage, snack or energy drink containing the above said herbal ingredient(s) for enhancing physical activity, physical fitness, mental alertness, enhancing energy levels, stamina levels, circulatory health, blood vessel health and for better mental health in warm blooded animal.
1. A method of increasing energy and/or mental alertness in a subject suffering from stress, fatigue, and/or obesity, comprising orally administering a biologically active composition to the subject, said biologically active composition comprising an effective amount of:
an organic or aqueous organic solvent extract of Sphaeranthus indicus , said solvent extract of Sphaeranthus indicus containing from 5% to 21% 7-hydroxyfrullanolide.
2. The method of claim 1 , wherein the biologically active composition further comprises:
at least one biologically active ingredient selected from the group consisting of extracts of Garcinia mangostana fruit rind, Osmium basilicum, Zingiber officinalis, Tribulus terrestris , vitamins, amino acids, taurine, an extract of Ginkgo biloba, Rhodiola and an extract of guarana,
said composition optionally containing an excipient, diluent or carrier.
3. The method of claim 1 , wherein the biologically active composition further comprises:
an extract of Garcinia mangostana fruit rind comprising an effective amount of α-mangostin, γ-mangostin, or a mixture thereof; and
at least one excipient, diluent or carrier.
4. The method of claim 1 , wherein said solvent extract of Sphaeranthus indicus is obtained by extraction of at least one plant part selected from the group consisting of leaves, flower heads, stem, root, whole plant, and mixtures thereof.
5. The method of claim 1 , wherein the solvent extract of Sphaeranthus indicus is selected from the group consisting of a C1 to C5 alcoholic solvent extract, a C1 to C7 hydrocarbon solvent extract, an ester solvent extract, a dichloromethane extract, a chloroform extract, an acetone extract, a methyl isobutyl ketone extract, and mixtures thereof.
6. The method of claim 1 , wherein said biologically active composition is formulated into a dietary supplement, food ingredient, beverage, snack or energy drink.
7. The method of claim 1 , wherein said organic solvent extract of Sphaeranthus indicus is obtained by extraction of flower heads.
8. A method of increasing energy and/or mental alertness in a subject suffering from stress, fatigue and/or obesity, comprising orally administering a biologically active composition to the subject said biologically active composition comprising an effective amount of:
an organic solvent extract of Sphaeranthus indicus comprising an effective amount of at least one frullanolide or eudesmanoid sesquiterpene compound, said organic solvent extract of Sphaeranthus indicus being selected from the group consisting of a C1 to C5 alcoholic solvent extract, a C1 to C7 hydrocarbon solvent extract, an ester solvent extract, a dichloromethane extract, a chloroform extract, an acetone extract, a methyl isobutyl ketone extract, and mixtures thereof.
9. The method of claim 8 , wherein the biologically active composition further comprises:
at least one biologically active ingredient selected from the group consisting of extracts of Garcinia mangostana fruit rind, Osmium basilicum, Zingiber officinalis, Tribulus terrestris , vitamins, amino acids, taurine, an extract of Ginkgo biloba, Rhodiola and an extract of guarana,
said composition optionally containing an excipient, diluent or carrier.
10. The method of claim 8 , wherein the biologically active composition further comprises:
an extract of Garcinia mangostana fruit rind comprising an effective amount of α-mangostin, γ-mangostin, or a mixture thereof; and
at least one excipient, diluent or carrier.
11. The method of claim 8 , wherein said at least one frullanolide or eudesmanoid sesquiterpene compound is selected from the group consisting of 7-hydroxyfrullanolide; 11α,13-dihydro-3α,7α-dihydroxy-4,5-epoxy-6β,7-eudesmanolide; 11β,13-dihydro-7α-acetoxy-3β-hydroxy-6β,7-eudesm-4-enolide; 3-keto-β-eudesmol; 11α,13-dihydro-3α,7α-dihydroxyeudesm-4-en-6α,12-olide; 11α,13-dihydro-3α,7α-dihydroxyfrullanolide; 11α,13-dihydro-7α,13-dihydroxyfrullanolide; 11α,13-dihydro-7α-hydroxy-13-methaoxyfrullanolide; 2α,7α-dihydroxy-4-en-11,13-dihydroeudesm-6,12-olide; 2α-hydroxycostic acid; 3-keto-7α-hydroxyeudesm-4-en-6,12-olide (cryptomeridiol); 4-epicryptomeridiol; sphaeranthanolide; 2α-hydroxysphaerantholide; 2α-acetoxysphaerantholide; 2α,7α-dihydroxysphaerantholide; 2α-acetoxy-7α-hydroxysphaerantholide and 2α-acetoxy-5α-hydroxyisosphaerantholide and mixtures thereof.
12. The method of claim 8 , wherein the effective amount of at least one frullanolide or eudesmanoid sesquiterpene compound is between 0.01% and 99.99%.
13. The method of claim 12 , wherein the effective amount of at least one frullanolide or eudesmanoid sesquiterpene compound is between 0.01% and 95%.
14. The method of claim 13 , wherein the effective amount of at least one frullanolide or eudesmanoid sesquiterpene compound is between 5% and 21%.
15. The method of claim 8 , wherein said biologically active composition is formulated into a dietary supplement, food ingredient, beverage, snack or energy drink.
16. The method of claim 8 , wherein said biologically active composition further comprises:
an organic or aqueous organic solvent extract of Sphaeranthus indicus , said solvent extract of Sphaeranthus indicus containing from 5% to 21% 7-hydroxyfrullanolide.
17. The method of claim 8 , wherein said organic solvent extract of Sphaeranthus indicus is obtained by extraction of flower heads.