Aromatic carboxylic acids in combination with aromatic hydroxyamides for inactivating non-enveloped viruses
The present invention is directed to antiviral compositions that provide efficacy against non-envelope viruses such as noroviruses. The antiviral compositions comprise an alcohol and a synergistic combination of an aromatic carboxylic acid and an aromatic hydroxyamide. The composition may be used as a topical on human skin, as a hand sanitizer or as a hard surface cleaning composition.
1. An antiviral composition having activity against non-enveloped viruses comprising:
salicylic acid in an amount between about 1 weight percent and about 2 weight percent of the composition; salicylamide in an amount of about 2 weight percent of the composition;
a C 1 -C 6 linear and/or branched alcohol; and
water;
wherein said antiviral composition has activity against non-enveloped viruses.
2. The antiviral composition of claim 1 , wherein said antiviral composition causes a greater than 3 log reduction in non-enveloped virus populations in less than one minute.
3. The antiviral composition of claim 1 , wherein said alcohol is ethanol, isopropanol or n-propanol or mixtures thereof.
4. The antiviral composition of claim 1 , wherein said salicylic acid is present in an amount of about 1 weight percent of said antiviral composition.
5. The antiviral composition of claim 1 , wherein said salicylic acid is present in an amount of about 1.5 weight percent of said composition.
6. The antiviral composition of claim 1 , wherein said antiviral composition has a pH of from about 1.0 to about 6.8.
7. The antiviral composition of claim 1 , further comprising a sulfonated surfactant.
8. The antiviral composition of claim 1 , wherein said antiviral composition provides virucidal activity of greater than 3 logs in 30 seconds and further provides bactericidal activity of greater than 3 logs in 30 seconds.
9. A method of reducing norovirus activity comprising: contacting a surface with the antiviral composition according to claim 1 .
10. The method of claim 9 , wherein said surface is skin.
11. The method of claim 9 , wherein said surface is a hard surface.
12. An antiviral diluted solution having virucidal activity against non-enveloped viruses comprising:
from about 40 weight percent to about 90 weight percent of a C 1 -C 6 linear and/or branched alcohol;
salicylic acid in an amount from about 1 weight percent to about 2 weight percent of the solution;
salicylamide in an amount of about 1 weight percent of the solution;
and water;
wherein said antiviral diluted solution has activity against non-enveloped virus.
13. The antiviral diluted solution of claim 12 , wherein said salicylic acid is about 1 weight percent of the solution.
14. The antiviral diluted solution of claim 12 , wherein said salicylic acid is about 1.5 weight percent of said solution.
15. The antiviral diluted solution of claim 12 , further comprising a sulfonated surfactant.
16. The antiviral diluted solution of claim 12 , wherein said solution further comprising benzoic acid, derivatives of benzoic acid, and/or derivatives of salicylic acid.
17. The antiviral composition of claim 1 , wherein said composition has antiviral activity against a norovirus.
18. The antiviral diluted solution of claim 12 , wherein said solution has antiviral activity against a norovirus.