DIAGNOSTIC METHOD
It has been demonstrated that the level of HBP increases in individuals that subsequently develop severe sepsis. Accordingly, the level of HBP, HBP/WBC ratio or HBP/NC ratio in an individual can be used to determine whether or not an individual is at risk of developing severe sepsis.
1 - 15 . (canceled)
16 . An agent for the detection of HBP for use in determining whether or not an individual is at risk of developing severe sepsis.
17 . An agent according to claim 16 wherein the agent comprises an HBP-specific antibody.
18 - 21 . (canceled)
22 . A test kit for use in a method for determining whether or not an individual is at risk of developing severe sepsis, which test kit comprises an agent for the detection of HBP in an individual.
23 . The kit of claim 21 additionally comprising means for the measurement of the WBC in an individual.