Topical Analgesic Compositions Containing Aliphatic Polyamines and Methods of Using Same
A method for producing local analgesia in a subject having a site of local discomfort comprises administration of an aliphatic polyamine and, preferably, urea. A composition of the invention comprises an aliphatic polyamine and preferably urea. The polyamine can be an alkylamine, such as, preferably, putrescine. The composition can also include lidocaine and/or a copper containing component.
1 - 41 . (canceled)
42 . A method for producing local analgesia at site of discomfort in a subject, the method comprising topically administering to the subject an aliphatic polyamine or a pharmaceutically acceptable salt thereof.
43 . The method of claim 42 , wherein the polyamine is an alkylamine and has up to fifteen carbon atoms.
44 . The method of claim 42 , wherein the polyamine is saturated or non-cyclic.
45 . The method of claim 42 , wherein the polyamine is putrescine, spermine, spermidine, or cadaverine.
46 . The method of claim 42 , wherein the polyamine is administered in the form of a composition comprising the polyamine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable diluent, carrier or delivery vehicle.
47 . The method of claim 46 , wherein composition is in the form of a cream, spray, ointment, gel, or lotion.
48 . The method of claim 46 , wherein the polyamine is present in the composition in an amount between: 0.1 and 10 wt %; 0.2 and 9 wt %; 0.3 and 8 wt %; 0.4 and 7 wt %; 0.5 and 6 wt %; 0.6 and 5 wt %; 0.7 and 5 wt %; 0.8 and 5 wt %; 1 and 4 wt %; 1 and 3 wt %; or 1 and 2 wt %.
49 . The method of claim 46 , wherein the composition further comprises a chaotropic agent.
50 . The method of claim 49 , wherein the chaotropic agent is urea, oleic acid, or a combination thereof.
51 . The method of claim 50 , wherein the urea is present in the composition in an amount of about: at least 5 wt %; at least 10 wt %; at least 15 wt %; at least 20 wt %; at least 25 wt %; at least 30 wt %; at least 35 wt %; or at least 40 wt %.
52 . The method of claim 49 , wherein the composition further comprises beta 1,3-D glucan.
53 . The method of claim 49 , wherein the composition further comprises lidocaine.
54 . The method of claim 42 , wherein the discomfort is the result of a physical injury, arthritis, rheumatism, headache, shingles, surgical pain, or a combination of any of the foregoing.
55 . The method of claim 42 , wherein the discomfort is the result of fibromyalgia.
56 . The method of claim 46 , wherein the composition is administered in the form of a transdermal patch.
57 . The method of claim 56 , wherein release of the polyamine from the patch is controlled to produce the analgesia over a period of time, wherein the period of time.
58 . A method for producing local analgesia at site of discomfort in a subject, the method comprising topically administering to the subject a composition comprising:
putrescine spermine, spermidine, or cadaverine, or a pharmaceutically acceptable salt thereof; and,
a chaotropic agent.
59 . The method of claim 58 , wherein the polyamine is putrescine and the chaotropic agent is urea.
60 . The method of claim 58 , wherein the composition is in the form of a cream, spray, ointment, gel, lotion, or a transdermal patch.
61 . The method of claim 58 , wherein the composition further comprises 1,3-D glucan, lidocaine or a combination thereof.