Bicyclic heterocyclic spiro compounds
There are provided certain bicyclic heterocyclic compounds that act as M1 muscarinic receptor modulators. Compositions containing these compounds and their use are also disclosed.
1. A method of treating a disease or condition selected from the group consisting of Alzheimer's disease, Insulin resistance syndrome, type-2 diabetes, Parkinson's Disease, Lewy Body Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Lobar Degeneration, comprising administering the compound of the structure
or a pharmaceutically acceptable salt thereof, to a patient having such a disease or condition.
2. The method of claim 1 , wherein the disease or condition is Alzheimer's disease.
3. The method of claim 1 , wherein the disease or condition is Insulin resistance syndrome.
4. The method of claim 1 , wherein the disease or condition is Alzheimer's disease.
5. The method of claim 1 , wherein the disease or condition is type-2 diabetes.
6. The method of claim 1 , wherein the disease or condition is Parkinson's Disease.
7. The method of claim 1 , wherein the disease or condition is Lewy Body Disease.
8. The method of claim 1 , wherein the disease or condition is Amyotrophic Lateral Sclerosis.
9. The method of claim 1 , wherein the disease or condition is Frontotemporal Lobar Degeneration.