COLLAGEN-BINDING SYNTHETIC PEPTIDOGLYCANS FOR USE IN VASCULAR INTERVENTION
This invention relates to collagen-binding synthetic peptidoglycans. More particularly, this invention relates to collagen-binding synthetic peptidoglycans for use in vascular intervention procedures. The invention also relates to kits comprising such collagen-binding synthetic peptidoglycans and catheters or stents.
1 . A method for vascular intervention, said method comprising the steps of
providing a collagen-binding synthetic peptidoglycan; and
administering the collagen-binding synthetic peptidoglycan to a patient, wherein the collagen-binding synthetic peptidoglycan is administered to the patient prior to during, or after the vascular intervention and binds to a denuded vessel in the patient.
2 . The method of claim 1 wherein the collagen-binding synthetic peptidoglycan inhibits platelet activation.
3 . The method of claim 1 wherein the collagen-binding synthetic peptidoglycan inhibits platelet binding to the denuded vessel.
4 . The method of claim 1 wherein the collagen-binding synthetic peptidoglycan inhibits intimal hyperplasia.
5 . (canceled)
6 . The method of claim 1 wherein the collagen-binding synthetic peptidoglycan inhibits thrombosis.
7 .- 9 . (canceled)
10 . The method of claim 1 wherein the collagen-binding synthetic peptidoglycan is a compound of formula
P n G x wherein n is 1 to 50;
x is 1 to 10
P is a synthetic peptide of about 5 to about 40 amino acids comprising a sequence of a collagen-binding domain; and
G is a glycan.
11 . The method of claim 1 wherein the collagen-binding synthetic peptidoglycan is a compound of formula
(P n L) x G wherein n is 1 to 7;
x is 1 to 50;
P is a synthetic peptide of about 5 to about 40 amino acids comprising a sequence of a collagen-binding domain;
L is a linker; and
G is a glycan.
12 . The method of claim 1 wherein the collagen-binding synthetic peptidoglycan is a compound of formula
P(LG n ) x wherein n is 1 to 5;
x is 1 to 10;
P is a synthetic peptide of about 5 to about 40 amino acids comprising a sequence of a collagen-binding domain;
L is a linker; and
G is a glycan.
13 . The method of claim 1 wherein the collagen-binding synthetic peptidoglycan is a compound of formula
P n G x wherein n is MWG/1000;
wherein MWG is the molecular weight of G rounded to the nearest 1 kDa;
wherein x is 1 to 10;
wherein P is a synthetic peptide of about 5 to about 40 amino acids comprising a sequence of a collagen-binding domain; and
wherein G is a glycan.
14 . The method of claim 1 wherein the collagen-binding synthetic peptidoglycan is a compound of formula
(P n L) x G wherein n is 1 to 7;
wherein x is MWG/1000;
wherein MWG is the molecular weight of G rounded to the nearest 1 kDa;
wherein P is a synthetic peptide of about 5 to about 40 amino acids comprising a sequence of a collagen-binding domain;
wherein L is a linker; and
wherein G is a glycan.
15 . The method of claim 1 wherein the glycan is a glycosaminoglycan or a polysaccharide.
16 .- 17 . (canceled)
18 . The method of claim 1 wherein the glycan is dermatan sulfate.
19 .- 20 . (canceled)
21 . The method of claim 1 wherein the collagen-binding synthetic peptidoglycan is DS-SILY 18 .
22 .- 39 . (canceled)
40 . A compound of the formula
P n G x wherein n is 10 to 25;
x is 1 to 10
P is a synthetic peptide of about 5 to about 40 amino acids comprising a sequence of a collagen-binding domain; and
G is a glycan.
41 . The compound of claim 40 wherein n is 15 to 25.
42 . The compound of claim 40 wherein n is 15 to 20.
43 . The compound of claim 40 wherein n is about 18.
44 . The compound of claim 40 of the formula P 18 G 1-10 .
45 . The compound of claim 40 of the formula P 18 G 1 .
46 . The compound of claim 40 wherein the compound is DS-SILY 18 .