Preservative free brimonidine and timolol solutions
The present invention is directed to preservative-free solutions of brimonidine and timolol for lowering intra-ocular pressure and treatment of glaucoma.
1. A preservative free brimonidine and timolol composition for lowering intraocular pressure in a human patient comprising the following formulation: about 0.2% w/v brimonidine tartrate; about 0.5% w/v timolol; about 2.15% w/v sodium phosphate dibasic heptahydrate; water and at a pH of about 6.9.
2. A preservative free brimonidine and timolol composition for lowering intraocular pressure in a human patient comprising the following formulation: 0.2% w/v brimonidine tartrate; 0.5% w/v timolol; about 2.15% w/v sodium phosphate dibasic heptahydrate; hydrochloric acid, sodium hydroxide, and water and at a pH of about 6.9.
3. The preservative free composition of claim 1 wherein the timolol is timolol maleate at 0.68% w/v and brimonidine is brimonidinetartrate.
4. A composition as described in Table 1.
5. The composition of claim 1 wherein the composition is a solution and is useful for treating glaucoma.
6. The composition of claim 1 wherein the composition is a solution and is contained in a unit dose kit form.
7. The composition of claim 1 wherein the composition is applied at least once a day.
8. The composition of claim 2 wherein the composition is applied twice a day.
9. The composition of claim 1 wherein the composition has greater bioavailability of brimonidine and timolol in the eye of the patient with fewer side-effects than brimonidine and timolol preserved with benzalkonium chloride.
10. A method of lowering IOP in a patient suffering from elevated IOP by administering the composition of claim 1 .
11. The preservative free brimonidine and timolol composition for lowering intraocular pressure of claim 1 , wherein the preservative free composition lowers intraocular pressure more effectively than the same composition preserved with benzalkonium chloride.